Medicine for inhibiting dietary obesity and polypeptide used by medicine

A technology of drugs and medicinal salts, applied in drug combinations, peptides, pharmaceutical formulations, etc., can solve problems such as toxic metabolites, side effects, and unlikely to escape protease degradation
CN114456232APending Publication Date: 2022-05-10INST OF ZOOLOGY CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF ZOOLOGY CHINESE ACAD OF SCI
Publication Date
2022-05-10

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Abstract

The invention provides a polypeptide for inhibiting dietary obesity. The amino acid sequence of the polypeptide is as follows: X1TX2YX3RTGR. The invention also provides application of the polypeptide. According to the polypeptide disclosed by the invention, the weight growth rate of experimental animals is reduced, subcutaneous and visceral fat deposition is reduced, occurrence and development of dietary obesity of experimental animals such as mice, rats and rhesus monkeys can be obviously inhibited by reducing appetite, and the abundance of intestinal symbiotic bacteria Akecmania of the experimental animals treated by the polypeptide is obviously improved.
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Description

technical field

[0001] The invention relates to a polypeptide for suppressing diet-induced obesity and its application. Background technique

[0002] Obesity is defined as a body mass index (BMI) ≥ 30kg / m 2 , global obesity has nearly tripled since 1975. It is estimated that more than 1.9 billion adults were overweight in 2014, of whom more than 600 million were classified as obese. Obesity is now becoming a global epidemic with a high risk of developing non-communicable diseases including type 2 diabetes (T2D), cardiovascular disease, stroke, cancer and depression, among others. Various strategies have been developed to combat obesity and overweight, mainly by reducing energy intake and increasing metabolic expenditure.

[0003] Small peptides are a promising class of molecules whose attractive pharmacological properties and excellent safety, tolerability, and efficacy have attracted increasing attention for their applications in medicine and biotechnology. At present, ...

Claims

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