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Medicine for inhibiting dietary obesity and polypeptide used by medicine

A technology of drugs and medicinal salts, applied in drug combinations, peptides, pharmaceutical formulations, etc., can solve problems such as toxic metabolites, side effects, and unlikely to escape protease degradation

Pending Publication Date: 2022-05-10
INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, apart from the fact that they are all injectable, the aforementioned peptides are longer than 20 amino acids and are therefore unlikely to escape protease degradation
However, small molecules also have some disadvantages: accumulation in organs and production of toxic metabolites, etc., which in turn lead to side effects

Method used

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  • Medicine for inhibiting dietary obesity and polypeptide used by medicine
  • Medicine for inhibiting dietary obesity and polypeptide used by medicine
  • Medicine for inhibiting dietary obesity and polypeptide used by medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Embodiment 1 mouse experiment

[0071] 1. SPF mouse experiment

[0072] C57 / Bl6J mice were used in the SPF mouse experiment. At the beginning of the experiment, C57 / Bl6J mice were 4 weeks old, and each weighed 15±1g. They were raised in a room with suitable temperature and humidity control, and the light / dark cycle was 12 hours. Diet and water, fed with standard laboratory feed (also known as growth and reproduction feed, product number SPFSLFZ003, product of SPFSLF (Beijing) Experimental Animal Technology Co., Ltd.), after a week of adaptation, were randomly assigned to cages, 4-6 per cage. Only.

[0073] 1.1 SPF mouse feeding experiment

[0074] A total of 12 treatments were set up, each with 2 cages of C57 / Bl6J mice, and each treatment was subjected to different feeding treatments, as follows:

[0075] NC group (i.e. normal diet group): fed with standard laboratory feed (also known as growth and reproduction feed, SPFSLFZ003), free to eat and drink, and fed 0.2ml ...

Embodiment 2

[0121] Embodiment 2 rat experiment and rhesus monkey experiment

[0122] 1. Rat experiment

[0123] 1.1 Feeding experiment

[0124] Sprague Dawley (SD) rats were used in the rat experiment. The rats were 4 weeks old at the beginning of the experiment, and each rat weighed 137±5g. They were raised in a room with suitable temperature and humidity control, with a 12-hour light / dark cycle, free to eat and drink , were fed a standard laboratory diet (growth and reproduction diet, SPFSLFZ003), and were randomly assigned to cages after one week of acclimatization. The HD treatment is represented by D3, and there are 3 treatments in total, and each treatment carries out different feeding treatments, as follows (see Figure 7 Figure a) :

[0125] NC group (i.e. normal diet group): 8 rats were fed with standard laboratory feed (also known as growth and reproduction feed, SPFSLFZ003), free to eat and drink for 10 weeks.

[0126] HFD group (i.e. high-fat diet group): 8 rats were fed w...

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PUM

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Abstract

The invention provides a polypeptide for inhibiting dietary obesity. The amino acid sequence of the polypeptide is as follows: X1TX2YX3RTGR. The invention also provides application of the polypeptide. According to the polypeptide disclosed by the invention, the weight growth rate of experimental animals is reduced, subcutaneous and visceral fat deposition is reduced, occurrence and development of dietary obesity of experimental animals such as mice, rats and rhesus monkeys can be obviously inhibited by reducing appetite, and the abundance of intestinal symbiotic bacteria Akecmania of the experimental animals treated by the polypeptide is obviously improved.

Description

technical field [0001] The invention relates to a polypeptide for suppressing diet-induced obesity and its application. Background technique [0002] Obesity is defined as a body mass index (BMI) ≥ 30kg / m 2 , global obesity has nearly tripled since 1975. It is estimated that more than 1.9 billion adults were overweight in 2014, of whom more than 600 million were classified as obese. Obesity is now becoming a global epidemic with a high risk of developing non-communicable diseases including type 2 diabetes (T2D), cardiovascular disease, stroke, cancer and depression, among others. Various strategies have been developed to combat obesity and overweight, mainly by reducing energy intake and increasing metabolic expenditure. [0003] Small peptides are a promising class of molecules whose attractive pharmacological properties and excellent safety, tolerability, and efficacy have attracted increasing attention for their applications in medicine and biotechnology. At present, ...

Claims

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Application Information

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IPC IPC(8): C07K7/06C12N15/11A61K38/08A61P3/04A61P3/06A61P1/00
CPCC07K7/06A61P3/04A61P3/06A61P1/00A61K38/00
Inventor 赵方庆李占占
Owner INST OF ZOOLOGY CHINESE ACAD OF SCI
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