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Preparation method and device of volatile oil, clathrate compound and preparation method of pharmaceutical composition

A technology of volatile oil and composition, which is applied in the field of preparation of volatile oil, can solve problems such as inability to clearly separate distilled water and difficulty in extraction, and achieve long-term stable drug efficacy, simple inclusion, and high purity

Pending Publication Date: 2022-05-31
YAAN THREE NINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The density of volatile oil in cassia twig is 1.04g / ml, which is very close to water. It cannot be clearly separated from distilled water in the large-scale production process, and it is difficult to extract. There is no relevant research on how to store the proposed volatile oil in medicine for a long time.

Method used

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  • Preparation method and device of volatile oil, clathrate compound and preparation method of pharmaceutical composition
  • Preparation method and device of volatile oil, clathrate compound and preparation method of pharmaceutical composition
  • Preparation method and device of volatile oil, clathrate compound and preparation method of pharmaceutical composition

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preparation example Construction

[0042] One aspect of the present invention relates to a method for preparing volatile oil, comprising the following steps:

[0043] The first raw material is subjected to the first mixed decoction, and the distillate is collected at the same time to obtain the first distillate; the first distillate is heated to obtain a distillation gas; the distillation gas is kept warm and condensed to obtain a second distillate; centrifuging after adding sodium salt to the second distillate;

[0044] The first raw material includes: Guizhi and Atractylodes Rhizome, or, the first raw material includes Poria cocos, Guizhi, Atractylodes macrocephala and licorice.

[0045] The preparation method of the volatile oil is simple and easy to operate, can clearly separate the volatile oil and water, has high extraction efficiency, and the extracted volatile oil can be stored in medicine for a long time.

[0046] During the second distillation, the method of reflux distillation is adopted to adjust t...

Embodiment 1

[0135] The preparation method of the volatile oil provided by the present embodiment comprises the following steps:

[0136] 1. Weigh 55.2kg of Poria decoction pieces, 41.4kg of Guizhi decoction pieces, 41.4kg of Atractylodes macrocephala decoction pieces and 27.6kg of licorice decoction pieces;

[0137] 2. Add Guizhi decoction pieces and Baizhu decoction pieces, add 414L of drinking water, soak for 1 hour, connect the volatile oil extractor, heat and decoct at 98°C, collect distilled water at the same time, and obtain 120L of distillate after 2 hours;

[0138] 3. Transfer the distillate obtained in step 2 to another extraction tank, connect the 60°C insulation pipe, then connect the 5°C cooler, and finally connect the volatile oil extractor, heat the extraction tank, the steam pressure is 0.2MPa, and collect the distillate , add 0.1 part of sodium chloride to the distillate, centrifuge and filter with suction to obtain 105.5ml of volatile oil.

Embodiment 2

[0140] The preparation method of the volatile oil provided by the present embodiment comprises the following steps:

[0141] 1. Weigh 55.2kg of Poria decoction pieces, 41.4kg of Guizhi decoction pieces, 41.4kg of Atractylodes macrocephala decoction pieces and 27.6kg of licorice decoction pieces;

[0142] 2. Add 828L of drinking water, soak for 1 hour, heat and decoct at 99°C and collect the distillate for 2 hours;

[0143] 3. Transfer the distillate obtained in step 2 to another extraction tank, connect the 60°C insulation pipe, then connect the 5°C cooler, and finally connect the volatile oil extractor, heat the extraction tank, the steam pressure is 0.3MPa, and collect the distillate , add 0.1 part of sodium chloride to the distillate, centrifuge and filter with suction to obtain 152ml of volatile oil.

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Abstract

The invention relates to the field of pharmacy, in particular to a preparation method and device of volatile oil, an inclusion compound and a preparation method of a pharmaceutical composition. The preparation method of the volatile oil comprises the following steps: performing first mixed decoction on a first raw material, and collecting distillate at the same time to obtain first distillate; heating the first distillate to obtain distilled gas; carrying out heat preservation and condensation on the distillation gas to obtain a second distillate; adding sodium salt into the second distillate, and centrifuging; the first raw materials comprise cassia twig and bighead atractylodes rhizome, or the first raw materials comprise poria cocos, cassia twig, bighead atractylodes rhizome and liquorice. The preparation method and the extraction method of the volatile oil are simple and easy to operate, the volatile oil and water can be clearly separated, the extraction efficiency is high, and the extracted volatile oil can be stored in a medicine for a long time.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a method for preparing volatile oil, a device, an inclusion compound and a method for preparing a pharmaceutical composition. Background technique [0002] The prescription of Linggui Zhugan Decoction was first recorded in Han Zhang Zhongjing's "Jin Kui Yao Lue Phlegm Retention Cough Disease Syndrome and Treatment No. 12" "If you are sick with phlegm retention, you should use warm medicine to counteract it. There is phlegm retention under the heart, and the chest and hypochondrium are full. For dizziness, Linggui Zhugan Decoction is the main remedy.... The husband is short of breath and has a slight drink, which should be removed from the urine, and Linggui Zhugan Decoction is the main remedy. Shenqi Pills are also the main remedy.” Original prescription of Linggui Zhugan Decoction: Poria cocos four liang, Guizhi Atractylodes atractylodes, Atractylodes macrocephala each three liang, licor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B9/02A61K36/54A61K47/69A61P43/00
CPCC11B9/027C11B9/022A61K36/076A61K36/54A61K36/284A61K36/484A61K47/6951A61P43/00A61K2236/331A61K2236/39A61K2300/00Y02A50/30
Inventor 蒋晓凤张翅胡莹莹吴建国唐莉
Owner YAAN THREE NINE PHARMA
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