Bi-crosslinking self-healing hydrogel and preparation method thereof

A hydrogel and double-crosslinking technology is applied in the field of double-crosslinking self-healing hydrogel and its preparation, which can solve the problems of the hydrogel structure being easily damaged, and achieve good application prospects and the effect of reducing usage.

Pending Publication Date: 2022-07-05
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the problem that the structure of the traditional hydrogel is easily destroyed during use, to provide a double cross-linked hydrogel with self-healing ability, and the preparation method of the hydrogel

Method used

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  • Bi-crosslinking self-healing hydrogel and preparation method thereof
  • Bi-crosslinking self-healing hydrogel and preparation method thereof
  • Bi-crosslinking self-healing hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] Synthesis of hexanoylated glycol chitosan (HGC). Weigh 0.2 g of ethylene glycol chitosan into 25 mL of deionized water, stir magnetically until the powder dissolves, add 25 mL of anhydrous methanol, and stir magnetically for 15-20 min. Pipette 0.25-0.43 mL of hexanoic anhydride, and slowly add it dropwise to the beaker under magnetic stirring, pour the solution into a dialysis bag for 24 hours, and dialyze with a large amount of deionized water for 2 days (replace the deionized water every 4 hours). water), and after freeze-drying in a freeze dryer, a white flocculent hexanoylated glycol chitosan product (HGC) was obtained.

[0020] Synthesis of oxidized methyl cellulose (DAMC). Methylcellulose and sodium periodate were added to 100 mL of deionized water at a mass ratio of 4:5 in the dark at room temperature. After 4 hours of reaction, 5 ml of ethylene glycol was added to neutralize excess periodate. Then, the product was dialyzed with distilled water in a dialysis t...

example 2

[0023] Hexoylated ethylene glycol chitosan was synthesized according to the method of Example 1.

[0024] Oxidized methylcellulose was synthesized according to the method of Example 1.

[0025] Preparation of HGC-DAMC double-crosslinked hydrogels. Take 40mg DAMC and 15mg HGC in a beaker, add 1mL deionized water, stir with a magnetic stirrer (TDZ4-WS, Hunan Xiangyi Centrifuge Instrument Co., Ltd.) for 5-10s, pour it into a cylindrical mold, and place it to shape. HGC-DAMC2 double-crosslinked self-healing hydrogel samples were prepared. And taking this as an example, the self-healing characterization is as follows figure 2 (Refer to the attached description for details).

example 3

[0027] Hexoylated ethylene glycol chitosan was synthesized according to the method of Example 1.

[0028] Oxidized methylcellulose was synthesized according to the method of Example 1.

[0029] Preparation of HGC-DAMC double-crosslinked hydrogels. Take 50mg DAMC and 15mg HGC in a beaker, add 1mL deionized water, stir with a magnetic stirrer (TDZ4-WS type, Hunan Xiangyi Centrifuge Instrument Co., Ltd.) for 5-10s, pour it into a cylindrical mold, and place it to shape. HGC-DAMC3 double-crosslinked self-healing hydrogel samples were prepared.

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Abstract

The invention relates to double-crosslinking self-healing hydrogel and a preparation method thereof. According to the hydrogel, ethylene glycol chitosan and methyl cellulose serve as raw materials, hexanoylated ethylene glycol chitosan (HGC) is generated through the reaction of ethylene glycol chitosan and hexanoic anhydride, methyl cellulose is oxidized through sodium periodate to obtain oxidized methyl cellulose (DAMC), then a dynamic imine bond is formed through the Schiff base reaction of the aldehyde group of the DAMC and the amino group on the HGC, and the dynamic imine bond is formed through the Schiff base reaction of the aldehyde group of the DAMC and the amino group on the HGC. And the HGC-DAMC hydrogel is prepared and obtained. The method is mild in reaction condition, simple and safe to operate and easier to accept by researchers. The prepared HGC-DAMC hydrogel has good self-healing capability, solves the problem that the structure of the traditional hydrogel is easy to damage in the use process, can realize self-healing under the condition of no external stimulation, and reduces the use of chemical cross-linking agents. The HGC-DAMC hydrogel has potential application value in the fields of injectable drug sustained-release carriers and the like.

Description

technical field [0001] The invention belongs to the field of polymer materials, and in particular relates to a double-crosslinked self-healing hydrogel and a preparation method thereof. Background technique [0002] Hydrogel is a polymer compound with a three-dimensional network structure synthesized from a hydrophilic polymer, which has the characteristics of water swelling but insolubility. Compared with other synthetic materials, hydrogels have water retention properties and good biocompatibility. In view of their unique water-soluble and hydrophilic characteristics, hydrogels become the best materials to simulate the functions of natural biological tissues, but they are soft. The characteristics make it vulnerable to damage, and the performance is greatly reduced after damage, such as macroscopic or microscopic cracks caused by mechanical or chemical factors, and it cannot continue to meet the requirements of use. [0003] Self-healing hydrogel refers to a type of hydro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L1/28C08L5/08C08G81/00A61K9/06A61K47/34
CPCC08J3/075C08J3/246C08G81/00A61K9/06A61K47/34C08J2301/28C08J2405/08Y02E60/13
Inventor 闫洁李征征徐文静
Owner TIANJIN UNIV OF SCI & TECH
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