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Mild cognitive function impairment diagnostic marker, kit and application thereof

A diagnostic kit and diagnostic marker technology are applied in the field of diagnostic markers, the prodromal stage of Alzheimer's disease, i.e. mild cognitive impairment, to achieve the effect of enriching the spectrum of diagnostic markers

Pending Publication Date: 2022-07-12
SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Clinically, there is no confirmed effective treatment to prevent or reverse AD, and only drugs can improve its symptoms, so early diagnosis becomes particularly important

Method used

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  • Mild cognitive function impairment diagnostic marker, kit and application thereof
  • Mild cognitive function impairment diagnostic marker, kit and application thereof
  • Mild cognitive function impairment diagnostic marker, kit and application thereof

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Experimental program
Comparison scheme
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Embodiment Construction

[0110] In order to describe the technical content of the present invention more clearly, further description will be given below with reference to specific embodiments.

[0111] Combine the following Figure 1 to Figure 9 , the specific examples of screening, verification, etc. of the diagnostic markers for mild cognitive impairment provided by the present invention will be described.

[0112] 1. Research objects

[0113] The subjects were 50 patients with mild cognitive impairment included in the Shanghai community assessment, and the control group was healthy elderly matched for age, sex, and years of education.

[0114] 2. Research methods

[0115] 1. CircRNA chip screening

[0116] (1) Use TRIzol LS Reagent to extract RNA from subjects' plasma samples, and use ND-1000 measures RNA concentration and purity.

[0117] (2) Extract the qualified RNA and digest the linear RNA with Rnase R (Epicentre, Inc.). The enriched circRNA was amplified by PCR using Arraystar Super R...

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Abstract

The invention relates to a marker for auxiliary diagnosis of peripheral blood in a profenodic stage of Alzheimer's disease, namely mild cognitive impairment (MCI), the marker is plasma CircRNA (Ribonucleic Acid), and the plasma CircRNA comprises circ-0004738, circ-0001490, circ-0003362, circ-0008289 and circ-0074719. The marker for auxiliary diagnosis of the peripheral blood in the profenodic stage of the Alzheimer's disease is a marker for auxiliary diagnosis of the peripheral blood in the profenodic stage of the Alzheimer's disease, and the marker for auxiliary diagnosis of the peripheral blood in the profenodic stage of the Alzheimer's disease is a marker for auxiliary diagnosis of the peripheral blood in the profenodic stage of the Alzheimer's disease. The invention also relates to application of the marker and a corresponding kit. The peripheral plasma CircRNA biomarker has the beneficial effects that the peripheral plasma CircRNA biomarker with relatively high diagnostic value on the Alzheimer's disease prophase, namely mild cognitive impairment is found, the MCI peripheral blood non-coding RNA diagnostic marker spectrum is enriched, and the early diagnosis and early intervention of MCI are facilitated.

Description

technical field [0001] The present invention relates to the technical field of Alzheimer's disease prodromal stage, namely mild cognitive impairment, in particular to the technical field of diagnostic markers, in particular to a mild cognitive impairment diagnostic marker and its application. Background technique [0002] Alzheimer's disease (AD) is a serious neurodegenerative disease that causes progressive and persistent cognitive impairment in patients, and eventually loses the ability to work and live. The third leading cause of disability and death among the elderly is people over the age of 60. According to the results of the seventh national census in my country, there are about 264 million people aged 60 and above, accounting for 18.70% of the national population [Ren Rujing, Yin Peng, Diagnostic Theory and Practice, 2021, 20(04): 317-337 ], of which about 15.07 million people over the age of 60 have dementia, about 9.83 million people have Alzheimer's disease, and t...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12Q1/6851
CPCC12Q1/6883C12Q1/6851C12Q2600/178C12Q2600/112C12Q2531/113C12Q2537/165C12Q2563/107
Inventor 王涛刘海宁纪敏秀
Owner SHANGHAI MENTAL HEALTH CENT (SHANGHAI PSYCHOLOGICAL COUNSELLING TRAINING CENT)
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