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Application of myristic acid in preparation of brain aging resisting medicine

A technology of myristic acid, brain aging, applied in the direction of drug combination, anhydride/acid/halide active ingredients, nervous system diseases, etc., to achieve the effect of improving exploration ability, improving spatial memory, and increasing percentage

Pending Publication Date: 2022-07-29
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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Problems solved by technology

The effects of MA on hippocampal neurons and brain aging have not been reported yet

Method used

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  • Application of myristic acid in preparation of brain aging resisting medicine
  • Application of myristic acid in preparation of brain aging resisting medicine

Examples

Experimental program
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Embodiment 1

[0024] In this example, natural aging mice were used to conduct experiments to study the therapeutic effect of MA on brain aging.

[0025] 1. Experimental materials and methods

[0026] 1. Mice

[0027] 22-month-old C57BL / 6 male mice were purchased from the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine (GZUCM) (animal production certificate #(Yue) 20180034). All animal experiments were approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (approval number TCMF1-2021026). The 22-month-old mice were randomly divided into two groups: 22-month-old mice (22M, intraperitoneal injection of the same amount of solvent) and MA (MA+22M, 2 mg / kg·d MA intraperitoneal injection). The drug is administered by intraperitoneal injection for 2 months. Following behavioral assessments (open field and water maze experiments), mouse brain samples were taken for subsequent experimental assessm...

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Abstract

The invention provides application of myristic acid in preparation of a medicine for resisting brain aging. It is found that myristic acid can effectively improve the exploration ability and space memory of naturally aged mice, improve neuron degeneration of the hippocampus, increase the percentage of hippocampus nick staining positive cells and reduce hippocampus aging marker proteins P16 and P21. Therefore, myristic acid can effectively resist brain aging and can be used for treating brain aging and brain aging related diseases, including Alzheimer's disease and encephalatrophy.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of myristic acid in the preparation of a medicine for anti-aging of the brain. Background technique [0002] With the rapid increase in the global aging population, brain aging and related diseases (such as Alzheimer's disease, brain atrophy, etc.) have brought a huge burden to patients, families, and socioeconomics. Alzheimer's disease (AD), also known as Alzheimer's disease, senile dementia, senile dementia, and dementia, is a persistent neurological disorder and the most common cause of dementia. The symptoms are gradually severe cognitive impairment (memory impairment, learning impairment, attention impairment, spatial cognitive function, problem-solving impairment), and gradually unable to adapt to society. At present, there is no specific drug to reverse brain aging, so it is imminent to explore the therapeutic drugs for brain aging. The hip...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/20A61P25/28
CPCA61K31/20A61P25/28
Inventor 任辉尚奇江晓兵沈耿杨陈桂锋张鹏陈弘林招文华余富勇余翔张志达刘慧雯
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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