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Cold resisting compound medicinal composition

A composition and drug technology, applied in drug combinations, anti-infective drugs, pharmaceutical formulations, etc., can solve problems such as inconvenience in work and life, adverse reactions, drowsiness, etc.

Inactive Publication Date: 2004-09-08
GUANGDONG BEIS DAILY HEALTH TONIC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many cold medicines on the market such as Tylenol, Baijiahei, Puganmin, Likeshu, Ganmaotong, Suxiaoganfeng Capsules, Ganmaoqing, etc., but because these cold medicines contain chlorpheniramine (chlorpheniramine maleate) respectively ) or diphenhydramine hydrochloride and other antihistamines that can pass through the blood-brain barrier and produce a sedative effect, often accompanied by adverse reactions of drowsiness
Inconveniencing the work and life of patients who need to keep their minds clear
[0004] US5100675 patent has applied for the composition of the compound cold medicine that contains loratadine, ibuprofen and pseudoephedrine, but its ibuprofen each dosage is 100mg, and daily dosage is 300mg, and after dosage is big and other medicines are combined group, can not Favorable as a once-daily sustained-release tablet
[0005] The cold medicine CLARIFLU of Schering-Plough of the United States, which has been listed in foreign countries and Hong Kong, contains 2.5 mg of loratadine, 60 mg of pseudoephedrine sulfate, and 500 mg of acetaminophen, twice a day. The daily dose is too large (1 gram per day) to be made into a once-daily tablet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment one. common tablet

[0028] Loratadine 3.33mg

[0029] Pseudoephedrine Sulfate 80mg

[0030] Diclofenac Sodium 25mg

Embodiment 2

[0031] Embodiment 2. Sustained-release tablet (once in 12 hours)

[0032] Loratadine 5mg

[0033] Pseudoephedrine 120mg

[0034] Diclofenac Sodium 37.5mg

Embodiment 3

[0035] Embodiment three. Sustained-release tablet (orally once in 24 hours)

[0036] Loratadine 10mg

[0037] Pseudoephedrine 120mg

[0038] Diclofenac Sodium 70mg

[0039] The preparation methods of the above tablets and sustained-release tablets are prepared according to conventional methods.

[0040] Compared with the previous medicine for relieving cold symptoms, the present invention has the following advantages: reasonable composition, scientific proportion, less dosage, and easy to make a sustained-release preparation to be taken once a day. It has fewer adverse reactions, especially no drowsiness, and is especially suitable for patients who need to stay awake and responsive, such as car drivers, machine operators, and workers working at heights. It has a better effect of relieving cold symptoms.

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PUM

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Abstract

The present invention is one compound medicine composition containing Locoratadine, psudophedrine, Diclofenac and medicinal acceptable salt. It is used in remitting cold symptoms.

Description

[0001] The invention relates to a pharmaceutical composition containing loratadine, pseudoephedrine, diclofenac and pharmaceutically acceptable salts thereof, which is used for relieving cold symptoms. Background technique [0002] Cold can be divided into common cold and influenza, very common clinically. Often accompanied by varying degrees of sneezing, nasal congestion, runny nose, fever, headache and body aches. There is no specific drug for the treatment of colds at present, and clinical treatment is mostly given to alleviate the above symptoms of patients. In order to alleviate cold symptoms, patients are often given compound cold medicines. [0003] There are many cold medicines on the market such as Tylenol, Baijiahei, Puganmin, Likeshu, Ganmaotong, Suxiaoganfeng Capsules, Ganmaoqing, etc., but because these cold medicines contain chlorpheniramine (chlorpheniramine maleate) respectively ) or diphenhydramine hydrochloride and other antihistamines that can pass through...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61P31/00
Inventor 贝庆生
Owner GUANGDONG BEIS DAILY HEALTH TONIC
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