Pharmaceutical formulations and use thereof in prevention of stroke, diabetes and/or congestive heart failure

A pharmaceutical preparation, diabetes technology, applied in the field of stroke prevention, diabetes and/or CHF, diabetes and/or congestive heart failure, prevention and/or treatment of stroke, can solve the problem of less prevention of cardiovascular diseases

Inactive Publication Date: 2002-12-11
SANOFI AVENTIS DEUT GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Said compounds are rarely used in the prevention of cardiovascular diseases, and the use of these compounds in the prevention of stroke, diabetes and / or CHF is so far unknown

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0049] A large clinical trial was designed to examine the effect of the ACE inhibitor ramipril compared with placebo in reducing cardiovascular events.

[0050] Study conducted over 6 years at 267 centers in 19 countries with 9,541 participants at high risk of cardiovascular events due to previous history of ischemic heart disease, stroke, peripheral arterial disease or individuals with diabetes.

[0051] Patients participating in the study had a mean systolic blood pressure of 138 mm Hg, so these patients were normotensive at the start of the study. After one month of treatment with ramipril or placebo, systolic blood pressure decreased by 5.48 mm Hg and 1.59 mm Hg, respectively.

[0052] The primary objectives of the study were myocardial infarction (MI), stroke, and cardiovascular (CV) death (mortality).

[0053]The study was stopped early because there was a very significant reduction in cardiovascular death, heart attack and stroke among patients taking ramipril. In ad...

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PUM

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Abstract

Novel use of an inhibitor of the renin-angiotensin system or derivative (I) in the manufacture of a medicament for the prevention of stroke in patients exhibiting normal or low blood pressure, diabetes and / or congestive heart failure (CHF) with no pre-existing CHF. Independent claims are also included for: a method of preventing of stroke in patients exhibiting normal or low blood pressure, diabetes and / or congestive heart failure (CHF) with no pre-existing CHF; and a formulation for use in the prevention of stroke in patients exhibiting normal or low blood pressure, diabetes and / or congestive heart failure (CHF) with no pre-existing CHF. ACTIVITY : Cerebroprotective; Cardiant; Antidiabetic. Treating 9,541 patients who are at risk for cardiovascular events due to a history of previous ischemic heart disease, stroke, peripheral arterial disease or individuals with diabetes with ramipril for 6 years resulted in a 32% reduction in the number of patients who developed a stroke, 21% who developed congestive heart failure, and 36% reduction who developed diabetes. MECHANISM OF ACTION : Angiotensin converting enzyme (ACE) inhibitor; an angiotensin II antagonist.

Description

field of invention [0001] The present invention relates to the use of inhibitors of the renin-angiotensin system (RAS) or pharmaceutically acceptable derivatives thereof in the manufacture of medicaments for the prevention of stroke, diabetes and / or congestive heart failure (CHF). The present invention also relates to a method for preventing and / or treating stroke, diabetes and / or CHF, the method comprising administering a therapeutically effective amount of a RAS inhibitor or a pharmaceutically acceptable derivative thereof to a patient in need of said prevention and / or treatment. Background of the invention [0002] Compounds that interfere with the RAS are known in the art and are useful in the treatment of cardiovascular disease, especially hypertension and heart failure. RAS can be interfered mainly by inhibiting the enzyme that synthesizes angiotensin or by blocking the corresponding receptor at the effector site. Currently available are angiotensin-converting enzyme ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/00A61K31/357A61K31/401A61K31/4025A61K31/403A61K31/404A61K31/41A61K31/4166A61K31/4178A61K31/4184A61K31/435A61K31/497A61K31/519A61K31/55A61K31/551A61K31/554A61P3/10A61P9/02A61P9/04A61P9/10A61P43/00C07D209/52
CPCA61K31/403A61P25/28A61P3/00A61P3/10A61P43/00A61P7/12A61P9/00A61P9/02A61P9/04A61P9/08A61P9/10A61P9/12A61P9/14A61K31/40A61K31/41A61K31/4178A61K31/4184A61K31/519
Inventor B·肖勒肯斯N·本德B·兰古恩瓦拉G·达格奈斯H·杰斯坦恩A·勒琼格仁S·尤索夫
Owner SANOFI AVENTIS DEUT GMBH
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