Application of chrysopdyose in preparing medicine to treat inflammatory enteropathy and its preparing process

A technology for inflammatory bowel disease and rhubarb polysaccharide, applied in the application and preparation field of rhubarb polysaccharide in the preparation of drugs for treating inflammatory bowel disease, can solve the problems of incomplete protein removal and low sugar content, and achieve the purpose of inhibiting the occurrence of loose stools The effect of high efficiency, abundant sources, and convenient administration

Inactive Publication Date: 2003-02-12
刘莉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, it is known that rhubarb polysaccharide has obvious hypolipidemic and anticoagulant effects, but this effect has not been applied in the field of pharma...

Method used

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  • Application of chrysopdyose in preparing medicine to treat inflammatory enteropathy and its preparing process
  • Application of chrysopdyose in preparing medicine to treat inflammatory enteropathy and its preparing process

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Embodiment Construction

[0018] The pharmacological test results of the present invention will be described below to illustrate its new application in the field of pharmacy, but the present invention is not limited to the following examples.

[0019] In laboratory experiments, different doses of TMP -1 Treat the colitis induced by TNBS in rats, and use TNBS to replicate the colitis model in rats, which can cause diarrhea and death in the rats; a large amount of necrosis of the intestinal wall and the formation of large ulcers can be seen with the naked eye, and the remaining intestinal mucosa is hyperemia and edema , Intestinal wall thickening; pathology shows massive infiltration of lymphocytes in the mucosa and submucosa, and can lead to the death of rats.

[0020] Referring to the accompanying drawings, the required rhubarb polysaccharides can be obtained through the following steps: ① pulverize the rhubarb; ② remove the fat-soluble components with ethanol, evaporate the residue to dry ethanol, ref...

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Abstract

An application of chrysopolyose in preparing medicines to treat inflammatory enteropathy is disclosed. A process for preparing chrysopolyose includes such steps as pulverizing rhubarb, removing liposoluble component, refluxing extraction with distilled water, concentrating, deposition, decolouring, removing protein by the freeze-thaw method several times then by the sevag method several times. determining by stags saccharide content, dialysis, filtering, concentrating, freeze-drying and depositing by stages in absolute alcohol.

Description

Technical field: [0001] The invention relates to the application of rhubarb polysaccharide in the field of pharmacy, in particular to the application of rhubarb polysaccharide in preparing medicine for treating inflammatory bowel disease and the preparation method thereof. Background technique: [0002] Rhubarb polysaccharide is isolated and purified from the traditional Chinese medicine rhubarb. The extraction method is to crush the rhubarb, remove the fat-soluble components with ethanol, and obtain the rhubarb polysaccharide through hot water extraction, ethanol precipitation, gel chromatography and the like. During the extraction process, the purity analysis was carried out by polyacrylamide gel electrophoresis, qualitative identification by ultraviolet and infrared spectroscopy, the sulfuric acid-phenol method and sulfuric acid-carbazole method were used to determine the sugar content and uronic acid content respectively, chromatography technology and gas chromatography ...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/00A61P29/00
Inventor 梅其炳刘莉
Owner 刘莉
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