Compound antibody vaccine of SARS virus antigen as well as its model of experimental animal and method

A SARS virus, antigen-antibody technology, applied in the direction of antibodies, antibody medical components, biological testing, etc., can solve problems such as unfavorable emergency emergency vaccinations

Inactive Publication Date: 2004-03-10
叶新新
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Traditional inactivated vaccines and modern subunit antigen protein vaccines require multiple vaccinations and relatively long humoral immune mechanism-induced stimulation reaction times to produce relatively strong immunity in the human body. Protein vaccines are not conducive to future emergency vaccinations to prevent new SARS outbreaks that may reoccur around the world

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0005] In order to achieve the above-mentioned purpose, implement the scheme that the present invention adopts: (1). SARS whole virus inactivated antigen obtained, and (2). 5~30 times of weight of human blood-derived specific polyclonal antibody fully mixed to form , can directly present viral antigens to antigen-presenting APC cell monocytes / macrophages, stimulate the immune response mechanism of the lymphatic immune system, shorten the time for the induction of the immune defense protection mechanism, and improve the anti-SARS vaccine non-responsive and low-responsive population against SARS The induction of the vaccine stimulates an immune response, a composite vaccine of SARS whole virus inactivated antigen and specific antibody. It is applied to the emergency vaccination for the prevention of the new SARS epidemic that may reoccur in the world. Adults are inoculated with 5ug~100ug of SARS whole virus inactivated antigen at one time. This kind of SARS whole virus inactivate...

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Abstract

A SARS virus antigen-antibody vaccine and its experimented method are disclosed. Said composite vaccine is prepared from the SARS virus antigen and specific antibody, and features that it can directly submit said virus antigen to the antigen presenting APC cells and mononuclear/macrophage for exciting the immune response mechanism of lymphatic immune system. Its advantages are high immune effect and specific target treatment to SARS.

Description

technical field [0001] The invention relates to a SARS virus antigen-antibody composite vaccine and an experimental method. It is a compound vaccine of SARS virus antigen and specific antibody, which can directly present the virus antigen to the antigen-presenting APC cell monocyte / macrophage, stimulate the immune response mechanism of the lymphatic immune system, and shorten the time for the induction of the immune defense protection mechanism. Improving the immune response induced by the SARS vaccine for non-responsive and low-responsive groups against SARS vaccine can provide effective anti-SARS virus infection immune defense for non-responsive and low-immune-responsive groups against SARS vaccine and asymptomatic SARS virus infection protection, and has a specific and targeted therapeutic effect against SARS virus infection. and SARS virus antigen-antibody complex vaccine experimental animal immune response comparison experimental model and experimental method. Backgrou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/215A61K39/395G01N33/53G01N33/536
Inventor 叶新新
Owner 叶新新
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