49 results about "Immune defence" patented technology

The present invention relates to a fusion protein capable of activating the complement system, the fusion protein comprising a first polypeptide sequence derived from a lectin-complement pathway activating protein or a functional homologue thereof; and a second polypeptide sequence derived from a collectin or a functional homologue thereof; wherein said complement activating protein is not a collectin. A preferred fusion protein comprises amino acids of the L-ficolin sequence of FIG. 1 and amino acids of the MBL sequence shown in FIG. 2. The fusion protein is suitable for use in treatment consisting of creation, reconstitution, enhancing and/or stimulating the opsonic and/or bactericidal activity of the complement system, i.e. enhancing the ability of the immune defence to recognise and kill microbial pathogens, and accordingly, the invention relates to a medicament comprising the fusion protein, methods for producing said fusion protein and methods for treating diseases, in particular infections.

The invention relates to a curcumin or curcumin-ramification-containing composite feed additive and a use thereof. The use of the additive can promote the growth of the animals, and/or protect the livers of the animals, and/or improve the oxidation resistance of the animals, reduce the generation of lipid peroxide, and improve the immunity and the disease resistance, and/or improve the stress resistance of the fish, avoid the problem of 'irritable haemorrhage', promote the secretion of fish mucus, and solve the problems that the cultivated fish is easy to loosen squama, easy to fall off, and lack of fish mucus. The invention further relates to a method for cultivating the animals and an animal feed which contains the composite feed additive having the curcumin or curcumin ramification.

The invention provides an antagonistic peptide which can simulate the key sequence for bonding MD2 and LPS and competitively antagonize the specific bonding which is generated by LPS and MD2, thus achieving the mitigation of the excessive activation of the immune inflammatory cells of LPS and further easing the caused excessive septic damages to the body. The amino acid sequence of the antagonist peptide includes: a sequence 1 of Lys Thr Val Pro Asp Asn His; and the sequence 2 of Ile Gly Lys Phe Leu Tyr Arg. The peptide can effectively mitigate the septic inflammation damage which is induced by the intracellular toxin LPS, thus significantly improving the survival rate of mouses which are infected by the intracellular toxin and maintaining the body immune defense function at the same time of specifically inhibiting the excessive stimulation of the LPS on the inflammatory cells. The antagonistic peptide can be used for preparing the treatment drugs of the inflammatory diseases which are caused by gram-negative bacteria and are related to a toll-like receptor protein.

The invention discloses crassostrea hongkongensis antimicrobial peptide sa-lectin as well as a recombinant expression method and application thereof. The gene coding sequence of antimicrobial peptide sa-lectin is shown in SEQ ID NO: 1, in which 156 amino acids are coded, and is shown in SEQ ID NO: 2, in which 16 amino acids at the end N are signal peptide sequences. According to the crassostrea hongkongensis antimicrobial peptide sa-lectin, a prokaryotic expression vector for removing the signal peptide sequence is constructed, so that sa-lectin recombined proteins are expressed and purified and can suppress growth of various types of gram-positive bacteria and gram-negative bacteria; furthermore, by the combination of sialic acid, an important effect is achieved in immune defense of shellfish.

The invention relates to preparations for dietary, food supplement or medical purposes and more specifically to a safe and natural preparation or a composition useful in immunity regulation and/or stimulation and in particular in the building, reinforcement, efficiency, maintenance and regeneration of natural immune defences in a subject. The preparations comprise magnesium, zinc and/or iron, blackcurrent seed oil and/or palm oil, two plant extracts selected from thyme, chickpea and lentil, as well as algae (fucus, wakame, nori), mushroom (shiitake, maitake) and at least one hydrosoluble vitamin and/or vitamin E.

A SARS virus antigen-antibody vaccine and its experimented method are disclosed. Said composite vaccine is prepared from the SARS virus antigen and specific antibody, and features that it can directly submit said virus antigen to the antigen presenting APC cells and mononuclear/macrophage for exciting the immune response mechanism of lymphatic immune system. Its advantages are high immune effect and specific target treatment to SARS.

The invention provides a vagina health probiotic composition. The vagina health probiotic composition comprises lactobacillus plantarum L-137 and at least one female probiotic, wherein the female probiotic is lactobacillus separated from the vagina or the urethra of a healthy female. The inactivated lactobacillus plantarum L-137 has the effect of promoting the growth of probiotics, especially thegrowth of the lactobacillus. The composition disclosed by the invention can recover vaginal flora, so that proliferation of harmful bacteria is inhibited, discomfort such as vaginal pain and itching and dryness can be relieved, peculiar smell is removed, the pH value is balanced, and the immune defense function of vaginal mucosa is enhanced. Vaginitis can be treated in an auxiliary manner; and thevaginitis can be prevented from happening and relapsing.

The invention discloses a tumor cell nanogold vesicle and a preparation method and application thereof, and a tumor cell immune nanogold vesicle and a preparation method and application thereof. The tumor cell nanogold vesicle adopts a core-shell structure consisting of an outer-layer vesicle and an inner core, the outer-layer vesicle is a cell membrane wrapping the inner core, the inner core consists of nanogold particles, and the outer-layer vesicle carries a tumor cell specific antigen. The tumor cell immune nanogold vesicle carries a peptide segment having the tumor cell specific antigen, and reserves characteristics of immunocyte. According to the nanogold vesicle generated through tumor cells, provided by the invention, on the base of keeping original thermal treatment of nanogold, the tumor specific antigen carrying mother cells is given to the vesicle, an organism is stimulated to produce immune response, relevant immune cells and factors are released for performing immunization killing on tumors, besides, system immune defence is activated, tumor metastasis is restrained, and tumor recurrence is restrained in a long-acting manner. The carried antigen information can be further presented to the immunocyte after being treated through antigen presenting cells, so that immune response is induced, and besides, immune treatment and thermal treatment of the tumor are realized.

This invention provides tools and methods that prevent a cancer cell from growing and reproducing more cancer cells. When growth ceases the body's immune defenses are enabled to attack and destroy these cells if the cancer cell itself has not initiated its own natural apoptotic self-destruction processes. The tools and methods of the invention obstruct the metabolic adaptions required to support cancer growth. By addressing the increased rates of metabolism characteristic of all rapidly reproducing cancer cells using chemical and/or physical nanotechnology to identify, segregate, isolate these hypermetabolizing cells, the body's immune system and other natural defenses are empowered to further isolate and eliminate the diseased cells. The extreme growth rates required for their rapid reproduction involve massively increased rates of the biochemical reactions supporting the cancerous growth. Each excess reaction produces extra heat and raises the internal cell's temperature and the tissue space immediate to the rapidly growing cells. This heat signature is used as a primary biomarker that enables binding of a nanoviral particle engineered to migrate to at attach at the target site at the site and prevent the cell from continued metabolism. Preferably, the nanoparticle not only binds and blocks external membrane receptors on the target cell, but incorporates into the rapidly metabolizing cells additional metabolic blocking agents to stop their growth. When cell growth and proliferation are stopped, the body's natural defenses are able to segregate and eliminate these cells. The massively increased rates of metabolic reactions characteristic of cancer cells also produce excess acid. The decreased pH is useful as a secondary or confirmatory marker for identifying these cancer cells.

The invention discloses a polypeptide immune activator for improving insect resistance and disease resistance of rice. The polypeptide composition contains any one of the following polypeptides as an active ingredient: OsPep1: ARLRPKPPGNPREGSGGNGGHHH; OsPep2: DDSKPTRPGAPAEGSGGNGGAIH; OsPep3: ADSAPQRPGSPAEGAGGNGGAVH; and OsPep7: SKPKPEPPGYPREGGGGNGGVVD. According to the activator, by externally spraying the polypeptide immune activator, the natural immune defense mechanism of the rice is activated, insect-resistant and disease-resistant secondary metabolites are synthesized, and the tolerance of the rice to plant diseases and insect pests is improved. Compared with traditional pesticides, the polypeptide immune activator is non-toxic, pollution-free, easy to degrade and free of residues; and compared with cultivation of disease-resistant and insect-resistant rice varieties, the polypeptide immune activator is efficient, convenient and easy to popularize.

The present invention concerns a combination of an elder (Sambucus nigra) extract and a strain of lactobacillus rhamnosus, intended to stimulate immunity and/or strengthen the immune defences and/or promote an anti-infection and/or anti-inflammatory immune response and/or help maintain vitality.

Compositions and methods for providing the hybrid benefit of treating biofilms on the surface of mammalian tissue, especially biofilms that occur in association with chronic wounds and burns, and simultaneously providing an antiseptic cleansing and maintenance of the stratum corneum of the tissue and other tissue surfaces, and an opportunity for the tissue to improve by engaging its own natural barrier and immunological defense properties. The compositions and methods prevent the re-establishment of biofilms by facilitating the reduction or eradication of the pathogen producing the biofilm before the biofilm can be established.

The invention relates to the technical field of genetic engineering and discloses a bactrian camel lysozyme protein gene, a recombinant protein and a cloning method thereof. The gene is a gene which is closely related to a gene related to glycoprotein synthesis of controlling nonheme iron associative property in the transferring family. The bactrian camel lysozyme protein gene and an evolutionary tree thereof can intuitively prove the difference between the bactrian camel lysozyme protein sequence and the protein sequence of other species, experimental data are provided for the functions of researching transfer of bactrian camel iron, realizing the broad-spectrum antibacterial and anti-virus function, regulating the in-vivo iron balance, promoting myelopoiesis, promoting cell growth, enhancing the body immunity and disease resistance and suppressing the tumor cells and disease treatment, a certain theoretical basis is provided for researching regulation of certain inflammatory responses and body immunity systems of the bactrian camel, other species and humans, and a certain biological basis is provided for research of body immune defense system; and therefore, the bactrian camel lysozyme protein gene has high application value.

This invention provides tools and methods that prevent a cancer cell from growing and reproducing more cancer cells in a diseased animal. When growth ceases the body's immune defenses are enabled to attack and destroy these cells if the cancer cell itself has not initiated its own natural apoptotic self-destruction processes. The tools and methods of the invention obstruct the metabolic adaptions required to support cancer growth. By addressing the increased rates of metabolism characteristic of all rapidly reproducing cancer cells using chemical and/or physical nanotechnology to identify, segregate, isolate these hypermetabolizing cells, the body's immune system and other natural defenses are empowered to further isolate and eliminate the diseased cells. The extreme growth rates required for their rapid reproduction involve massively increased rates of the biochemical reactions supporting the cancerous growth. Each excess reaction produces extra heat and raises the internal cell's temperature and the tissue space immediate to the rapidly growing cells. This heat signature is used as a primary biomarker that enables binding of a nanoviral particle engineered to migrate to at attach at the target site at the site and prevent the cell from continued metabolism. Preferably, the nanoparticle not only binds and blocks external membrane receptors on the target cell, but incorporates into the rapidly metabolizing cells additional metabolic blocking agents to stop their growth. When cell growth and proliferation are stopped, the body's natural defenses are able to segregate and eliminate these cells. The massively increased rates of metabolic reactions characteristic of cancer cells also produce excess acid. The decreased pH is useful as a secondary or confirmatory marker for identifying these cancer cells.

The invention relates to the technical field of drugs, and relates to a preparation method of a two-component drug for treating tinea pedis. By virtue of oral administration and external application,the tinea pedis can be jointly healed; a component A is prepared, an extracted vitamin B family belongs to water soluble vitamins and has efficacies for regulating the metabolism, facilitating the regeneration of cells, keeping the health of the foot skin, preventing reoccurrence of the tinea pedis and improving the immunity system and the nervous system; the Chinese herb decoction has efficaciesfor clearing away the internal heat, eliminating the toxicity, repelling the wind, removing the dampness, nourishing the kidney, tonifying Qi, clearing and activating the channels and collaterals, promoting the foot bottom blood circulation, improving the immunity defense capacity of the body, promoting the healing of the tinea pedis, adjusting the immunity mechanism of the body, and controlling the reoccurrence and reducing the occurrence of the tinea pedis. The boric acid has an effect of inhibiting mycete, the salicylic acid can inhibit the fungus, soften the epidermis and remove cutin; methenamine has an effect of hidroschesis and convergence; the zinc oxide has an effect for relieving the itching and converging; phenol has a sterilizing and disinfecting effect; metronidazole can resist the anaerobic infection; nitrofurazone has an inflammation eliminating effect; and the two-component drug easily coats the skin surface to form a film, thereby playing the effect and promoting the healing of the tinea pedis.

A Chinese medicine in the form of ointment for treating psoriasis is prepared through proportioning scorpion and croton seed, pulverizing, proportionally mixing with plant oil, laying aside at 30-37 deg.C for 7 days, fusing mineral grease in hot water bath, and proportionally mixing them together. Its advantage is high curative effect (97% of effective rate).

The invention provides a perna viridis antibacterial peptide Pernalins, and a signal peptide, coding gene and application thereof. The perna viridis antibacterial peptide Pernalins is selected from one or more of Pernalin A, Pernalin B, Pernalin C and Pernalin D, and the amino acid sequences of the Pernalin A, the Pernalin B, the Pernalin C and the Pernalin D are respectively as shown in SEQ ID NO: 1 to SEQ ID NO: 4. After perna viridis is infected with vibrio parahaemolyticus, the antibacterial peptide Pernalins in the blood lymphocytes can respond to immune defense, has a continuous immune defense effect for a long time, and maintains the immune response of an organism.

The invention provides a repairing essence for regulating stability of epithelial immune microenvironment based on adaptogen and a preparation method of the repairing essence, and the repairing essence comprises the following components in percentage by mass: 0.01-1% of beta-glucan, 1-20% of a saccharomycetes lysate, 1-20% of an organic maguey extract, 0.2-5% of ectoine, 0.3-10% of a tricholoma matsutake extract, 0.5-10% of blue-green algae extract, 0.5-5% of hydrolyzed royal jelly protein, 1.6-8.8% of humectant, 0.15-1.2% of preservative and the balance of water. The repairing essence provided by the invention is based on an immune regulation system of an organism, promotes proliferation of fibroblasts and production of extracellular matrixes, and inhibits expression of MMP-1 matrix metalloproteinase, so that immune self-stabilization and immune defense capabilities of skin are regulated, skin tissue immune internal and external environments are recovered to be relatively stable, and the rapid relieving and repairing of skin inflammatory symptoms are realized.

The invention provides a method for preparing antibacterial peptide by inducing fly maggots through salmonella, and relates to the technical field of biological preparation. A method for preparing antibacterial peptide inducing fly maggots through salmonella comprises the following steps: feeding the fly maggots with resuspended salmonella, culturing to obtain live fly maggots capable of generating immune defense, cleaning and disinfecting, extracting with an extracting solution, centrifuging, taking supernate, carrying out boiling water bath, cooling and centrifuging, concentrating and storing a crude extract, and sequentially eluting and collecting through a gel column G75 and a gel column G25 to obtain the purified maggot antibacterial peptide. According to the invention, salmonella is used for inducing fly maggots and stimulating generation of high-expression antibacterial peptide, the crude extracted antibacterial peptide is separated and purified by a gel chromatography column, the fly maggot antibacterial peptide component with high antibacterial activity is obtained, and the preparation method is simple and easy to operate.

The invention discloses an antiviral oral spray and a preparation method thereof, and belongs to the technical field of oral sprays. The spray comprises the following effective components in parts byweight: 30-50 parts of chrysanthemum, 20-25 parts of mulberry leaves, 20-25 parts of honeysuckle, 5-10 parts of lavender, 10-15 parts of mint, 10-15 parts of thyme, 10-15 parts of salvia officinalis,25-30 parts of momordica grosvenori, 15-20 parts of wild blueberries, 15-20 parts of ocimum sanctum, 10-15 parts of Luowenguo, 10-15 parts of acai and 10-20 parts of asparagus lettuce leaves. The antiviral oral spray is prepared by compatibility of medicinal and edible plant extracts, is free of any chemical drugs and hormones, sufficiently exerts the synergistic effect between medicinal and edible plants and edible plants, achieves the effect of directly preventing and inhibiting viruses, can also enhance the body immunity of patients, and stimulates and mobilizes an immune defense system ofa patient body to achieve the effect of indirectly resisting viruses.