55 results about "Immune defence" patented technology

The invention discloses a CAPE polypeptide released by a protein coded by a soybean disease course related gene GmPR1-6 and application of the CAPE polypeptide. The nucleotide sequence of the soybean disease course related gene is as shown in SEQ ID NO.1, the amino acid sequence of protein coded by the soybean disease course related gene is as shown in SEQ ID NO.2, and the sequence of CAPE polypeptide released at the C terminal of the protein is as shown in SEQ ID NO.9. The soybean disease course related gene GmPR1-6 provided by the invention is a gene coding a core protein participating in soybean immune defense reaction, the C tail end of the GmPR1-6 protein can be sheared to release CAPE polypeptide, the CAPE polypeptide is externally applied to weaken early immune defense reaction triggered by soybean during infection of rhizobium, the weight and size of a single root nodule are increased, and the disease resistance of the soybean is improved. The symbiotic nodulation and nitrogen fixation capabilities of the soybeans are improved, and the method has potential application value in planting of leguminous plants.

The invention discloses application of jute nanocellulose or derivatives thereof in preparation of drugs or feeds for preventing and treating bee virus infection, and belongs to the technical field of bee breeding. It is found that the jute nanocellulose can significantly improve the survival rate of Italian bees infected with chronic paralysis virus (CBPV) and reduce the death rate of the Italian bees. The jute nano-cellulose can inhibit proliferation of CBPV in bees and reduce the copy number of viruses. Meanwhile, the level of intestinal probiotics reduced due to CBPV infection can be recovered, and the congenital immune defense capability of bees is improved. The jute nanocellulose can be used for preparing drugs or feed additives for preventing and treating CBPV infection, has important significance on preventing and treating chronic paralysis viruses of Italian bees, and has good market application value.

The present invention belongs to the field of antimicrobial peptides in biotechnology, and specifically relates to an antimicrobial peptide, a recombinant antimicrobial peptide of the antimicrobial peptide, and a preparation method and application thereof. The amino acid sequence of the antimicrobial peptide is shown in SEQ ID NO: 1, and the nucleotide sequence of the gene expressing the antimicrobial peptide is shown in SEQ ID NO: 2. A recombinant antimicrobial peptide of the antimicrobial peptide is prepared, and the antimicrobial peptide or recombinant antimicrobial peptide can be used to inhibit the growth of Streptococcus suis and exhibit a highly efficient bactericidal effect on Streptococcus suis by increasing cell membrane permeability, or to participate in the regulation of IMD and Toll pathways, or to enhance the immune defense system of Lepidoptera Sphenopteridae insects, and improve the antimicrobial ability of Lepidoptera Sphenopteridae insects. The antibodies produced by using the antimicrobial peptide or recombinant antimicrobial peptide can be used to track the above antimicrobial peptide or the above recombinant antimicrobial peptide, or to promote the expression of multiple antimicrobial peptides of insects, or to specifically recognize, bind and shield antigens.

The invention discloses a natural tobacco extract and application thereof in prevention and treatment of plant viruses, and belongs to the technical field of agricultural drugs and biology. A natural extract is obtained from tobacco leaves slightly infected with viruses, and experiments show that when the tobacco natural extract is sprayed on the plant leaves infected with the viruses, the immune defense capability of plants can be induced, propagation and replication of the viruses can be effectively inhibited, the disease resistance of the plants is enhanced, and the effect of preventing and treating the viruses is achieved. Therefore, the purpose of improving crop yield and quality is achieved. The natural tobacco extract can be used as an effective component of a plant antiviral agent, and a new direction is provided for research and development of the plant antiviral agent. The method for preventing and treating plant viruses by externally spraying the natural tobacco extract has the advantages of being environmentally friendly, non-toxic and harmless, is an ideal plant virus prevention and treatment technology, is simple and efficient, can keep high stability and practicability in field application, and meets the current requirements for ecological safety and sustainable development.

The invention discloses application of probiotic yeast microcapsules in drugs for targeted regulation of inflammatory macrophage immunity, and belongs to the technical field of biological medicines. As a novel medicine, the yeast microcapsule has the characteristics of engineering, convenience, low cost, high patient compliance, high safety and excellent targeting property, can be used as an oral medicine for treating chronic inflammatory disease rheumatoid arthritis, acts on mitochondria through oxidative stress and oxidative phosphoric acid pathways, inhibits excessive activation of macrophages, and has the effect of treating chronic inflammatory disease rheumatoid arthritis. Release of inflammatory factors is reduced, and inflammatory reaction is relieved; the yeast micro-capsule can promote the phagocytosis and antigen presentation function of macrophages and enhance the immune defense capability of a body, so that the immune function of the macrophages is adjusted, and the yeast micro-capsule shows huge potential in preparation of drugs for targeted adjustment of inflammatory macrophage immunity, and has a broad application prospect in preparation of drugs for targeted adjustment of inflammatory macrophage immunity. And a theoretical basis is provided for developing non-invasive, convenient and safe treatment of chronic inflammatory diseases such as rheumatoid arthritis.

The invention relates to a method of predicting an outcome of a subject having a glioma, comprising determining or receiving the result of a determination of a first gene expression profile for each of one or more immune defense response genes, and / or of a second gene expression profile for each of one or more T-Cell receptor signaling genes, and / or of a third gene expression profile for each of one or more PDE4D7 correlated genes, said first, second, and third expression profile(s) being determined in a biological sample obtained from the subject, determining the prediction of outcome based on the first gene expression profile(s), or on the second gene expression profile(s), or on the third gene expression profile(s), or on the first, second, and third gene expression profile(s), and, optionally, providing the prediction to a medical caregiver or the subject.

The invention relates to the technical field of chemical toxicology, in particular to an evaluation method for comprehensively analyzing the immune induction effect of a plasticizer by using caenorhabditis elegans, according to the evaluation method, a mother worm breeding mode is changed to replace a lysis solution to synchronize nematodes, experimental interference is reduced, the result accuracy is improved, monitoring indexes are newly increased, intestinal injuries and in-vivo bacterial indexes are increased, and the evaluation method is suitable for comprehensive analysis of the immune induction effect of the plasticizer. The evaluation is more accurate and reliable by combining oxidative stress indexes and performing two-dimensional comprehensive evaluation from an intestinal immune defense line and oxidative stress, and by drawing a multi-index monitoring shape graph, adopting a comprehensive biomarker response index analysis method and associating immune-related representative indexes, the evaluation accuracy is improved. According to the method, the change of each index and the immunity intensity on the caenorhabditis elegans under different exposure conditions are intuitively presented, the immune defense effect of the caenorhabditis elegans under the stress of the plasticizer can be quickly and effectively evaluated without transcriptome and metabonomics, and efficient evaluation is realized.

The present disclosure provides a scalable and practical off-the-shelf allogeneic T cell therapy for treating cancer including employing a population of nonexhausted allogeneic virus specific CD4+ T cells, CD8+ T cells or CD4+ and CD8+ T cells that express a nonexhausted PD-1negTIGITnegTCF-1High TOXLo early stem cell TSCM phenotype. The virus-specific population of CD4+ T cells, CD8+ T cells or CD4+ and CD8+ T cells that expresses the nonexhausted early stem cell TSCM phenotype and comprises TCRs specific for a protein of a virus is genetically modified to stably express up to three chimeric antigen-receptors (CARs). Each CAR is specific for a cancer antigen. At least one of the CARs comprises a CD30 CAR expressing a CD30-specific scFv fragment, and / or a chimeric alloimmune defense receptor (ADR); and / or a chimeric HLA accessory receptor fused with a cytolytic endodomain of the T cell receptor zeta chain, thereby reducing risk of host versus graft rejection (HVGR). In some regimens, multiple populations of cells can be combined and co-infused as the off the shelf T cell therapies.

The invention discloses a Ruditapes philippinarum miR-263b inhibitor and application thereof, and finds that Ruditapes philippinarum miR-263b can regulate and control innate immune response of a host by targeting RpSC2, negatively regulates activation of an immune-related signal channel in a vibrio infection process, and further, on the basis of a molecular regulation and control mechanism, the Ruditapes philippinarum miR-263b inhibitor can be used for inhibiting the infection of vibrio. The invention discloses a specific inhibitor which is completely complementary with a miR-263b mature body sequence. Experimental data show that after Ruditapes philippinarum is injected with the miR-263b inhibitor, the expression level of miR-263b in vivo is reduced, and the inhibition effect of miR-263b on RpSC2 is effectively relieved, so that the expression level of a target gene RpSC2 is up-regulated, an NF-kappa B immune signal channel is activated, the immune defense capability of the Ruditapes philippinarum on vibrio anguillarum is enhanced, the death rate after infection is remarkably reduced, and the Ruditapes philippinarum is prevented from being infected. The in-vivo bacterium loading amount is obviously reduced, and the pathological injury of hepatopancreas tissue is obviously relieved.

The present invention relates to the field of medicine, and in particular to the use of Rv0927c protein in the preparation of anti-tumor drugs, wherein the Rv0927c protein includes an amino acid sequence as shown in SEQ ID NO: 1. The Rv0927c protein may be a natural Rv0927c protein or a recombinant Rv0927c protein. The Rv0927c protein is a protein having an amino acid sequence as shown in SEQ ID NO: 1, or a fusion protein formed by connecting a protein having an amino acid sequence as shown in SEQ ID NO: 1 with a carrier protein, an antibody or other amino acid fragments of any length. The tumor is selected from lung cancer. The Rv0927c protein does not produce excessive immune rejection reactions, does not damage the host's immune defense ability while inhibiting the proliferation of lung cancer cells, and can avoid causing side effects.

The invention discloses a fermented ginseng-probiotic-natural antibacterial peptide composite oral liquid with an active immune defense function and a preparation method thereof, and belongs to the technical field of functional health food. The oral liquid is prepared by compounding a fermented ginseng matrix, an active probiotic preparation, a fly maggot source natural antibacterial peptide extract and auxiliary materials, and the activity of the components is guaranteed through a whole-course cold chain preparation process. On the basis of a microbial counterbalance theory, a human body active immune defense system is constructed by utilizing the synergistic effect of the fermented ginseng, the probiotics and the antibacterial peptide, and the limitation of traditional passive medical treatment is broken through; the shelf life of the product at 0-5 DEG C reaches 12 months, and the product is convenient to take and high in safety. The invention has the advantages of simple preparation process, wide raw material source and suitability for large-scale production, and has extremely high practical value in the field of human health protection.

The invention discloses a composition for preventing and treating oral diseases or conditions, a preparation method and application thereof. The external vesicles based on oral pathogenic bacteria are rich in nano-scale vesicles of immune activation and defense factors aiming at periodontitis, and after the external vesicles enter a body through oral mucosa administration, the external vesicles are passively targeted into lymph nodes related to the oral mucosa to induce mucosa immune specific antibody expression, so that the immune defense capacity to the pathogenic bacteria is improved. Preferably, a calcium phosphate shell is coated outside the oral bacterial outer vesicle, and the calcium phosphate shell can only be dissolved under an acidic condition, so that the engineered vesicle can be degraded after targeting to lymph nodes and being phagocytosed into dendritic cell lysosome, and the inflammatory reaction of a drug delivery area is avoided. The administration form of the sublingual disintegrating tablet can improve the bioavailability of the vaccine while local mucosal administration activates mucosal immunity, and the convenient administration form is also beneficial to the promotion and popularization of the periodontitis vaccine in clinical chair-side diagnosis and treatment or grassroots communities.

The invention relates to a dietary supplement for reducing the level of oxidative stress in the body and enhancing immune defence. The composition contains a) a source of zinc, b) a source of anthocyanins, c) a source of vitamin C, and d) a source of copper.

Provided are a composition for preventing and treating an oral disease or condition, a preparation method therefor, and the use thereof. The composition comprises extracellular vesicles derived from oral pathogenic bacteria. The extracellular vesicles are nanoscale vesicles rich in immune activation and defensive factors against pathogenic bacterial infection. Upon administration via the oral mucosa into a body, the vesicles are passively aimed at lymph nodes associated with the oral mucosa to induce the expression of a mucosal immunity-specific antibody, thereby enhancing immune defense against pathogenic bacteria. The extracellular vesicles of oral pathogenic bacteria are coated with a calcium phosphate shell, and the shell is soluble only under acidic conditions and degrades only after the extracellular vesicles are aimed at the lymph nodes and are phagocytosed into lysosomes of dendritic cells, thereby avoiding inflammatory reactions in an administration area. By using a sublingual disintegrating tablet as the form of administration, the bioavailability of a vaccine can be enhanced while achieving the local administration at the mucosa and activating mucosal immunity. Moreover, the composition is convenient to administer, which is conducive to the diagnosis and treatment of oral bacterial infectious diseases.

The invention discloses a functional food for improving immunity and belongs to the field of health-care foods. Comprising the following substances in parts by weight: 15-20 parts of chitosan oligosaccharide, 4-6 parts of astragalus polysaccharide, 2-4 parts of lucid ganoderma oligosaccharide, 2-4 parts of Chinese wolfberry oligosaccharide, 1-2 parts of codonopsis pilosula polysaccharide, 2-4 parts of ginseng oligosaccharide, 6-8 parts of lentinan, 6-10 parts of Chinese yam polysaccharide, 2-4 parts of oat peptide, 1-2 parts of pericarpium citri reticulatae polysaccharide, 6-8 parts of soybean peptide and 10-15 parts of whey protein peptide. The various components have a synergistic effect, the polysaccharide components can enhance the activity of immune cells, the peptide substances can promote the generation of immune factors, and the synergistic effect of the polysaccharide components and the peptide substances is beneficial for improving the immune defense capability of the body and improving the immunity of the human body.

The invention belongs to the technical field of feed processing, and particularly relates to germinated broad bean feed for improving intestinal health of tilapia mossambica and a preparation method of the germinated broad bean feed. The germinated broad bean feed capable of improving intestinal health of tilapia mossambica provided by the invention is mainly prepared from the following raw materials: fish meal, soybean meal, cottonseed meal, rapeseed meal, wheat bran, rice bran, wheat middling, soybean oil, choline chloride, a vitamin premix, a mineral element premix, monocalcium phosphate, germinated broad beans, a mildew preventive and the like. The germinated broad bean feed prepared by the invention not only can reduce the diameter of muscle fibers of tilapia mossambica muscle and increase the density, but also can increase the hardness and collagen content of the muscle, so that the meat quality of the tilapia mossambica is more compact, tasty and crisp, and the breeding quality is improved. Meanwhile, the germinated broad bean feed can also improve intestinal inflammation of the tilapia mossambica, promote intestinal health, improve the immune defense function of the tilapia mossambica and improve the health condition of the crisp tilapia mossambica, and can effectively promote sustainable development of the crisp tilapia mossambica industry.

The invention discloses a preparation method and application of a composition for improving cold resistance of bees. The composition is prepared by performing compound fermentation on Chinese herbal medicine liquid, lactobacillus buchneri, lactobacillus reuteri and bacillus Zhongmuran, the Chinese herbal medicine liquid is prepared from the following raw materials in parts by mass: 9 parts of rhizoma polygoni cuspidati, 30 parts of radix astragali, 15 parts of radix paeoniae alba, 9 parts of radix isatidis and 8 parts of rhizoma dioscoreae nipponicae; the selected probiotics have strong protease production capacity and good antibacterial effect, and are sensitive to various antibiotics. The composition disclosed by the invention can be used for enhancing the immune defense capability of bees in the wintering period, reducing the possibility of disease occurrence and improving the overall survival rate; and the composition has no drug residue while improving the cold resistance of the bees in winter, shows huge sustainable development potential when being applied to bee breeding, and brings economic benefits and social benefits to bee keepers.

The present invention discloses a natural tobacco extract and its application in preventing and controlling plant viruses, belonging to the fields of agricultural drugs and biotechnology. The present invention obtains a natural extract from tobacco leaves slightly infected with viruses. Experiments have found that spraying the natural tobacco extract on virus-infected plant leaves can not only induce the immune defense ability of the plant, but also effectively inhibit the spread and replication of the virus, enhance the disease resistance of the plant, thereby achieving the purpose of improving crop yield and quality. The natural tobacco extract can be used as an effective ingredient of a plant antiviral agent, providing a new direction for the research and development of plant antiviral agents. The method of using an exogenous spray of the natural tobacco extract to prevent and control plant viruses has the advantages of being green, environmentally friendly, non-toxic and harmless, and is an ideal plant virus prevention and control technology. It is simple and efficient, and can maintain high stability and practicality in field applications, meeting the current requirements for ecological safety and sustainable development.

The present invention relates to the use of an extract of aerial parts of Diospyros spp. and / or the use of compositions comprising an extract of aerial parts of Diospyros spp. to combat senescence and to combat skin ageing and / or preserve and / or reinforce the immune defences of the skin and / or preserve and / or reinforce the skin barrier function.

The invention discloses a triple dynamic immune defense compound nutrient as well as a preparation method and application thereof, and relates to the technical field of immunity. The composition consists of red algae sulfated polysaccharide, beta-glucan, an elderberry extract, an echinacea purpurea extract, lactoferrin, nano-selenium, nano-zinc, citric acid and high fructose corn syrup according to a specific ratio. The core of the invention lies in that a triple dynamic immune defense shield theory of'oropharyngeal mucosa barrier (immediate defense)-system immune activation (short-term mobilization)-specific immune regulation (long-term consolidation) 'is proposed and constructed in the field of food for the first time, and through the cooperation of multiple mechanisms of physical blocking, biological inactivation, immune training and long-term regulation, the immunity of the oral pharyngeal mucosa is enhanced. And broad-spectrum prevention and auxiliary intervention on various viruses are realized. All the raw materials with homology of medicine and food and the food nutrition enhancer are adopted, so that the safety is high, and the applicable crowd is wide.

The invention relates to application of an APOBR gene as a target spot in preparation of a preparation for preventing and / or treating talaromyces marneffei infection, and belongs to the technical field of medical application. The invention provides application of an APOBR gene as a target spot in preparation of a preparation for preventing and / or treating talaromyces marneffei infection. A nucleotide sequence of the APOBR gene is shown as SEQ ID NO. 1. The APOBR protein is proved to play a key role in the phagocytic function of THP-1 macrophages, so that a new target spot is provided for diagnosis, prevention and treatment of TM infection and research and development and application of related vaccines, drugs or immunologic adjuvants, and it is indicated that new anti-infection drugs can be developed through targeting APOBR genes or related signal channels of the APOBR genes. Therefore, the TM invasion and proliferation are inhibited, and the immune defense capability of a host is enhanced.

The present application relates to the field of agricultural biotechnology, in particular to locust immune related protein LmEaster gene and application thereof. The present application clones LmEaster gene and synthesizes double-stranded RNA, adopts injection method to treat locusts, and detects the mortality of locusts in each treatment and the expression amount change of related antibacterial peptide, and confirms that after interfering with LmEaster gene of locusts, the expression amount of antibacterial peptide of locusts is increased, the immune defense ability of locusts is increased, and then the mortality is reduced.

The invention relates to a shrimp culture method based on a precise thermal therapy strategy, and belongs to the field of aquaculture, the method comprises the following steps: regularly monitoring culture water temperature, preventing water temperature layering, and ensuring that the whole water temperature of the culture water is uniform and the temperature control is precise; when WSSV infection is detected, starting a thermal therapy method: raising the culture water temperature to 32-36 DEG C, or raising the temperature of a WSSV virus concentration area on a shrimp body at a fixed point while the culture water temperature is raised until the virus copy number is reduced or reduced to be negative; and a cooling and rehabilitation stage: reducing the water temperature to a normal culture temperature, continuously and regularly detecting the WSSV load of the shrimps after cooling, and confirming that the shrimps are not repeatedly infected with the WSSV and are stable in physiological status. According to the method, virus replication is intervened and inhibited through thermal therapy, the immune defense capability of the shrimps can be improved through thermal therapy at 32 DEG C or above, and the WSSV viruses in the shrimps are thoroughly removed.

The invention relates to the technical field of biological pharmacy, in particular to an immunopotentiator containing high-activity microbial protein peptide and a preparation method of the immunopotentiator. The immunopotentiator containing the high-activity microbial protein peptide comprises the following raw materials: beta-glucan, composite immune peptide, a freeze-drying protective agent, a metal organic framework and the balance of a stabilizer. The preparation method comprises the following steps: firstly, constructing an immune activation core skeleton by using beta-glucan, and activating a phosphorylation pathway by using Kluyveromyces marxianus source peptide in the composite immune peptide; the silkworm chrysalis protein peptide is in targeted combination with a receptor compound, so that the phagocytic rate of macrophages is increased; the recombinant lactoferrin peptide destroys a lipid bilayer of a microbial cell membrane through a cationic structural domain, activates a TLR4 pathway to promote lymphocyte differentiation, and ensures that the systematic immune defense efficacy is improved; specific antibacterial protein contained in the Fusarium brachypodium FXFB001 fermentation active protein extract can directly destroy a pathogen cell membrane structure and activate a TLR2 / 4 pathway to enhance innate immune response at the same time.

The application provides a bifidobacterium longum subsp. infantis and application thereof to enhancing adaptive immune response in early life, and belongs to the technical field of microorganisms. The bifidobacterium longum subsp. infantis provided by the application is named bifidobacterium longum subsp. infantis HH020, and the preservation number is GDMCC No:65828. Research shows that the bifidobacterium longum subsp. infantis can promote immune development in early life by regulating tryptophan metabolic pathways, enhance adaptive immune response in early life, thereby enhancing immune defense capacity and improving immune health.

The invention provides a method for detecting a disease-resistant infection gene of sturgeons. The method comprises the following steps: identifying a fish disease-resistant gene in sturgeons, and analyzing a gene structure and an amino acid sequence of the fish disease-resistant gene; the expression distribution of the antipathogenic gene in different organs of the healthy sturgeon is detected through RT-qPCR; the expression mode of the mRNA of the pathogen-resistant gene of the sturgeon after pathogen infection is analyzed. The method can be used for identifying the antipathogenic gene of sturgeon participating in anti-pathogen immune defense, and is of great significance to prevention and treatment of sturgeon diseases.

The invention relates to the technical field of biological medicines, and particularly discloses a vaccine adjuvant composition as well as a preparation method and application thereof. The vaccine immune composition provided by the invention comprises GM-CSF and cortex albiziae saponin, and has the following advantages: 1, the vaccine immune composition can significantly improve the specific antibody level and the cytokine secretion efficiency, effectively promote the activation of killer T cells, efficiently induce the response of memory T cells, and construct a stable immune defense basis; 2, the immune level of the organism can be remarkably improved after challenge, the tissue injury risk is reduced by inhibiting replication and colonization of viruses in key target organs, and meanwhile, the body weight of the organism is promoted to be quickly recovered after challenge, so that the physiological homeostasis of the organism is better maintained; thirdly, the method is wide in adaptability and can be compatible with various veterinary vaccines such as foot-and-mouth disease vaccines, porcine reproductive and respiratory syndrome vaccines, pseudorabies vaccines and porcine circovirus type 2 vaccines. The method can be applied to the fields of research, development and preparation of vaccine adjuvants or vaccines and the like.

The invention discloses a pharmaceutical composition for inhalation and application thereof, the pharmaceutical composition comprises a therapeutically effective amount of interleukin-6 and a pharmaceutically acceptable solubilizer, the solubilizer is selected from at least one of cyclodextrin and a surfactant, and the weight percentage of the solubilizer in the composition is 0.5-60%. The composition effectively improves the solubility and stability of IL-6 by adding a solubilizer, making it suitable for pulmonary topical delivery. The pharmaceutical composition can safely induce the lung to generate neutrophil defensive infiltration in an aerosol inhalation mode, namely, the neutrophil is collected to the lung in advance on the premise of not causing obvious inflammatory response and tissue damage, so that the innate immune defense capability of a host to subsequent pathogen infection is enhanced.

The invention discloses a Brucella CTL (cytotoxic T lymphocyte) antigen epitope peptide and application thereof, the Brucella CTL antigen epitope peptide is any one or more of the following epitope polypeptides, and the amino acid sequences of the epitope polypeptides are shown as SEQ ID NO.1-3; according to the present invention, the CTL immune response is accurately activated, the immune defense requirement of Brucella intracellular infection is met, the core component is provided for the novel Brucella subunit vaccine, and the risks of virulence reversion, diagnosis interference and the like of the traditional attenuated live vaccine are avoided.

The invention relates to the technical field of biological medicine, in particular to application of salvianolic acid in preparation of an anti-tuberculosis drug. The invention provides application of salvianolic acid A or pharmaceutically acceptable salt thereof in preparation of the anti-tuberculosis drug, the molecular formula of the salvianolic acid A is C26H22O10, and the structural formula is shown in formula I. When the salvianolic acid A is applied to preparation of the anti-tuberculosis drug, a brand new material basis is provided for research and development of the anti-tuberculosis drug, damage of the drug to normal tissues of a human body is reduced, and the anti-tuberculosis drug can be applied to preparation of the anti-tuberculosis drug. Toxic and side effects are reduced. From the aspect of action mechanism, the salvianolic acid A has various biological activities such as inflammation resistance, oxidation resistance and immunoregulation, and can inhibit the growth and reproduction of mycobacterium tuberculosis and enhance the immune defense capability of the body to tubercle bacillus through the multi-target synergistic effect, thereby achieving the purpose of treating tuberculosis.