Active substance combination for medicamentous therapy of habituation of or habitual material or narcotics

A technology of active ingredient and composition, applied in the field of active ingredient composition and its drug treatment in addictive substances or anesthetics, which can solve the problem of no synergy

Inactive Publication Date: 2004-09-08
HF ARZNEIMITTELFORSCHUNG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For certain drinkers, the problem is that once a specific personal drinking limit is exceeded, a general loss of control with the above-mentioned undesirable side effects soon follows
An example of such a combination of active ingredients is the combination of calcium acetylhomotaurate and naltrexone described in EP 0945133. These two drugs have been used for many years in the treatment of alcohol abuse, however, recent studies ( Neurosci.Behav.2001; 23(2):109-118) shows that this combination has no synergistic effect

Method used

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  • Active substance combination for medicamentous therapy of habituation of or habitual material or narcotics
  • Active substance combination for medicamentous therapy of habituation of or habitual material or narcotics

Examples

Experimental program
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Embodiment 1

[0089] The medicament is administered orally or transdermally, and a single dose contains 1 mg to 50 mg of galantamine in the form of one of its pharmacologically acceptable salts, preferably as its hydrobromide or addition The compound exists in the form of 100 mg to 5000 mg of a pharmacologically acceptable salt of N-acetyl homotaurine, preferably the potassium salt.

Embodiment 2

[0091] Medicament for oral or transdermal use, and a single dose comprising 1 mg to 50 mg of galantamine in the form of one of its pharmacologically acceptable salts, preferably in the form of its hydrobromide salt or addition compound 1-Amino-3,5-dimethyladamantane present and 1 mg to 50 mg.

Embodiment 3

[0093] Medicament for oral or transdermal use, and a single dose comprising 10 mg to 500 mg of deoxyhalamine in the form of one of its pharmacologically acceptable salts, preferably in the form of its hydrochloride or addition compound And 100mg-5000mg of a pharmacologically acceptable salt of N-acetyl homotaurine, preferably potassium salt.

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Abstract

The invention relates to an active ingredient combination of at least one modulator of the cholinergic system and at least one substance with an anti-excitatory action for treating a dependence on addictive substances or narcotics, in particular for treating alcoholism.

Description

technical field [0001] The present invention relates to active ingredient compositions and their use in the drug treatment of addictive substances or narcotics, especially in relation to the treatment of alcohol abuse. In this respect, the active ingredient composition consists of at least one modulator of the cholinergic system plus at least one substance having antiexcisive activity. The invention further relates to the use of said combination of active ingredients for the manufacture of medicaments for the treatment of addictive substance or narcotic use, especially alcohol use. Background technique [0002] Intake of addictive substances and narcotics, especially alcohol, is known to cause symptoms such as sensory disturbances, memory loss, cognitive impairment, general loss of control, aggression, and impairment of muscle coordination. If these anesthetics are ingested intentionally, although these effects are expected by the user of the anesthetic, they can also have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/13A61K31/16A61K31/185A61K31/40A61K31/473A61K31/485A61K31/505A61K31/519A61K31/535A61K31/55A61K36/18A61P25/30A61P25/32A61P43/00
CPCA61K31/519A61K31/485A61K31/185A61K31/55A61P25/00A61P25/30A61P25/32A61P43/00A61K2300/00
Inventor 约阿希姆·莫尔曼赫尔曼·穆克克劳斯·欧皮兹
Owner HF ARZNEIMITTELFORSCHUNG
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