39results about How to "Reduce alcohol consumption" patented technology

The gene responsible for encoding SERT has a functional polymorphism at the 5′-regulatory promoter region, which results in two forms, long (L) and short (S). The LL-genotype is hypothesized to play a key role in the early onset of alcohol use. The present invention discloses the differences in treatment and diagnosis based on the L or short genotypes as well as on a single nucleotide polymorphism of the SERT gene, the 3′ UTR SNP rs 1042173. The present invention demonstrates the efficacy of using the drug ondansetron and similar drugs for treatment based on variations in the polymorphisms of the SERT gene as well as methods for diagnosing susceptibility to abuse of alcohol and other addiction-related diseases and disorders.

The present invention provides for compositions and methods for treating or preventing addictive and compulsive diseases and disorders, particular alcohol-related diseases and disorders, disclosed herein. The GLP activators of the present invention are effective against various alcohol and drug dependency diseases. In accordance with the invention, the present compositions and methods can be used to intercede upstream or downstream in the signal transduction cascade involved in GLP action to treat various alcohol and drug dependency diseases. In one embodiment, the synthesis or release of endogenous GLP can be stimulated. In another embodiment, the endogenous synthesis or release of another molecule active in the cascade downstream from GLP, (e.g., a molecule produced in response to GLP binding to a receptor), can be stimulated. Accordingly, the methods and compositions of the invention are useful for preventing, treating, diagnosing, or monitoring the progression various alcohol and drug dependency diseases disclosed herein.

The invention belongs to the field of production of sodium carboxymethylcellulose, and specifically relates to a production method of technical-grade sodium carboxymethylcellulose, wherein the method is low in production cost and can be carried out on a solvent method production line. The method comprises the following steps: a, preparation of liquor; b, alkalization reaction; c, acidification and etherification. The purpose of production on the original solvent method production line is realized by adopting a method of increasing the water content of a reaction system and reducing the use level of alcohol of the reaction system by means of adjusting and controlling parameters of the reaction system; the cost of producing technical-grade sodium carboxymethylcellulose [CMC-LVT (Carboxymethylcellulose-Low Viscosity Technical) and CMC-HVT (Carboxymethylcellulose-How Viscosity Technical)] by the original solvent method is lowered.

The present invention is directed to compounds according to formula, (R²R³)-A⁰A¹-c(A²-A³-A⁴-A⁵-A⁶-A⁷-A⁸-A⁹)-A¹⁰-R¹, wherein the definitions of A¹ to A¹⁰ and R¹ to R³ are provided in the application, and pharmaceutically-acceptable salts thereof, that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals, and to pharmaceutical compositions comprising said compounds.

A method for extracting and separating the sodium pyruvate from the pyruvate fermentation broth by adopting the double membrane two-step process comprises the following steps: 1. the sodium pyruvate concentrated solution is extracted and separated through the double membrane process; 2. the sodium pyruvate concentrated solution is used for preparing the sodium pyruvate solids: the sodium pyruvate concentrated solution goes through the production steps such as the ethanol precipitation, separation of the precipitates from the mother liquors, drying, grinding, screening, inspection, finished product packaging, etc. so as to obtain the qualified sodium pyruvate solids. The invention has the advantages of short production process, high product purity, high utilization ratio, high automation degree, few contamination caused to the environment, low production cost, etc., and is especially suitable for the industrialized large-scale production of the sodium pyruvate.

The invention discloses a 1+1 clarification method. Coarse particles as well as macromolecular impurities such as starch, tannin, phlegmatic temperament and protein in traditional Chinese medicine extracting liquid are adsorbed and removed by utilizing the agglomeration and flocculation effects of a 1+1 clarifying agent, and the stability of a water extract is destroyed, so that the aims of refining and improving the quality of a finished product preparation are fulfilled. The 1+1 clarifying agent comprises a component A and a component B, wherein the component A is a sodium alginate solution;the component B is a chitosan modified activated carbon solution; the adding sequence of the component A and the component B is changed according to the pH value of clarifying liquid; after the firstcomponent is added, bridging connection is conducted among macromolecules with different solubility, the molecules are enlarged rapidly, and the second component performs bridging on the basis of a composite formed by the first component to enable floccules to be formed rapidly on the original basis; due to the use of a chitosan-sodium alginate copolymer, the flocculation effect is enhanced; furthermore, compared with alcohol precipitation, the 1+1 clarification method has the characteristics of low production cost, simple operation process, short production cycle and the like in the aspect of traditional Chinese medicine purification and impurity removal.

The invention provides an alcoholysis process of an organosilicon monomer azeotrope and a method for comprehensively utilizing the organosilicon monomer azeotrope based on the alcoholysis process. According to the alcoholysis process, under the vacuum condition, azeotrope is sequentially subjected to a liquid-phase alcoholysis reaction and a gas-phase alcoholysis reaction with liquid-phase alcoholand gas-phase alcohol, the process does not need to carry out low-boiling-point substance removal treatment on the azeotrope in advance, process steps and equipment investment are reduced, and energyconsumption and cost are reduced; meanwhile, the alcoholysis efficiency is high, generated hydrogen chloride can be removed in time, side reactions are avoided, and the alcohol consumption is obviously reduced. A process for preparing polysiloxane from tetraalkoxysilane and a process for preparing hexamethyldisiloxane by hydrolyzing trimethylchlorosilane are added at the downstream of an alcoholysis process, so that the aim of comprehensively utilizing azeotrope is fulfilled.

The invention discloses a condensation type toilet water and a preparation method thereof; the condensation type toilet water mainly consists of the ingredients with the shares by weight: 0.1 to 1 share of menthol, 0.2 to 2 shares of borneol, 20 to 30 shares of alcohol, 0.5 to 5 shares of skin care ingredient, 0.03 to 2 shares of macromolecule resin, 0.1 to 1 share of acidifying or alkalizing agent and 59 to 79.07 shares of water. The preparation method is that the menthol and the borneol which are matched according to the proportion are dissolved in the alcohol, and the macromolecule resin is dispersed in water, after being evenly stirred at high speed, the mixture is added with the skin care ingredient to be stirred evenly and at last is added with the acidifying or alkalizing agent; the pH of the preparation is adjusted to be 6.5 to 7.5; finally, the mixture is mixed into the alcohol that is dissolved with the menthol and the borneol, so as to obtain the finished product. The finished product of the condensation type toilet water is of semisolid condensation form, which is immediately transformed into liquid form when being smeared on the skin, thereby promoting the active ingredient to be released rapidly to take effect; after condensation type toilet water is smeared on the skin, no residue is left on the skin; the condensation type toilet water also can greatly reduce the using quantity of the alcohol, and dose not stimulate the skin, can be directly smeared on the skin without being diluted and is convenient for use.

The invention discloses a printing ink drying and exhaust gas treatment system. The printing ink drying and exhaust gas treatment system is applied to a printing drying tunnel, and comprises a dehumidifying unit and a catalytic combustion unit; an outlet of the dehumidifying unit communicates with an air inlet of the printing drying tunnel; an air exhaust port of the printing drying tunnel communicates with an air inlet of the catalytic combustion unit; the dehumidifying unit comprises a dehumidifying device and a heat exchanger; an inlet of the dehumidifying device communicates with the outside; the outlet of the dehumidifying device communicates with a first inlet of the heat exchanger; a first outlet of the heat exchanger communicates with the outlet of the dehumidifying unit; the catalytic combustion unit comprises a catalytic bed; and air entering the air inlet of the catalytic combustion unit passes through the catalytic bed, a second inlet of the heat exchanger, and a second outlet of the heat exchanger sequentially, and communicates with the outside. According to the printing ink drying and exhaust gas treatment system, dry air provided by the dehumidifying unit can increase the water consumption of a diluent, reduce the amount of alcohol usage, and save costs; heat generated by the exhaust gas treatment system is used for drying, so that the energy consumption for drying is reduced, and the exhaust pollution is reduced.

A computer system and method is disclosed as a support structure for patients with hypertension or prehypertension to encourage life style changes leading to dietary control, increase exercise and blood pressure control. The method includes automated messages and responses delivered in real time to encourage appropriate actions by the patient. A diary feature is provided for user input of various relevant parameters, such as foods consumed, exercise activities, body weight, blood pressure, and heart rate. The computer system and method may be implemented on a mobile computing device, such as a smart phone or wearable, a conventional personal computer, or a web service. Most functions will be provided on the mobile device, but some housekeeping and data visualization functions may be limited to the personal computer or web service implementations.

A computer system and method is disclosed as a support structure for patients with hypertension or prehypertension to encourage life style changes leading to dietary control, increase exercise and blood pressure control. The method includes automated messages and responses delivered in real time to encourage appropriate actions by the patient. A diary feature is provided for user input of various relevant parameters, such as foods consumed, exercise activities, body weight, blood pressure, and heart rate. The computer system and method may be implemented on a mobile computing device, such as a smart phone or wearable, a conventional personal computer, or a web service. Most functions will be provided on the mobile device, but some housekeeping and data visualization functions may be limited to the personal computer or web service implementations.

The present invention relates to methods of inhibiting or reducing voluntary alcohol consumption in a subject comprising administering a selective melanocortin 4 receptor agonist to said subject. The present invention further relates to methods of treating or preventing alcoholism, alcohol abuse, and alcohol related disorders in a subject comprising administering a selective melanocortin 4 receptor agonist to said subject. The present invention further provides for pharmaceutical compositions and medicaments useful in carrying out these methods.

The invention belongs to the technical field of biodiesel preparation and particularly relates to a biodiesel preparing method. Waste grease is used for preparing biodiesel through an acid-base two-step synthesizing method. The biodiesel preparing method comprises the following steps that firstly, the waste grease is subjected to acid washing with water, activated carbon adsorption and centrifugal separation treatment; secondly, methyl alcohol or ethyl alcohol, carbonic ester and an acid catalyst are added and heated for reflux esterification; thirdly, an esterified product is added with alkali to regulate pH, and methyl alcohol or ethyl alcohol and an alkali catalyst are added and heated for reflux esterification exchange; fourthly, after a reaction is finished, methyl alcohol or ethyl alcohol is steamed out through reduced pressure, washing, centrifugal layering and film evaporation drying are carried out, and biodiesel is obtained. The biodiesel preparing method has the advantages of being high in yield and reaction speed, low in energy consumption and production cost and the like, and is suitable for commercialized production.

The invention discloses a printing ink drying system. The printing ink drying system is applied to a printing drying tunnel, and comprises a dehumidifying unit and a recycling unit; the dehumidifyingunit comprises a dehumidifying rotating wheel; an inlet of the dehumidifying rotating wheel is connected with an inlet of the dehumidifying unit; a drying gas outlet of the dehumidifying wheel is connected with an outlet of the dehumidifying unit; the recycling unit comprises at least one adsorption tank, a condenser and a drying fan; a first port of the adsorption tank is connected with the inletof the recycling unit; a second port of the adsorption tank is connected with an outlet of the recycling unit; a third port of the adsorption tank is connected with the condenser; a fourth port of the adsorption tank is connected with the outside; and a fifth port of the adsorption tank is connected with the inlet of the drying fan. By adopting the system, air is dried through the dehumidifying unit, and then enters the printing drying tunnel for drying; when used for drying, the dehumidified air can reduce drying temperature, save energy, and also facilitate the evaporation of moisture during a drying process; and the water consumption of a diluent is increased and the amount of alcohol usage is reduced. The recycling unit can be adopted to recycle the discharged alcohol and ammonia gas.

The invention discloses a method for extracting procyanidine by using pine bark, which comprises the following steps: taking the endodermis of pine bark as a raw material, and adding water which is 10-20 times of the weight of the raw material for extraction to obtain an extracting solution; keeping the extracting solution at the temperature of 50 DEG C to 70 DEG C for 1-2 hours, centrifuging theextracting solution, and removing fine particles and residues to obtain centrifugate; standing the centrifugate for 2-4h to obtain a clarified extracting solution; slowly feeding the clarified extracting solution into a macroporous resin column, carrying out selective adsorption, flushing the resin with purified water or deionized water, discharging impurities, and carrying out hydrolytic washingwith 30-50% alcohol for 2-3 times, so as to obtain an alcohol eluent of procyanidine; further concentrating the eluent to obtain a concentrated solution with the percentage concentration of 11-18%; and drying the concentrated solution at 210-220 DEG C to obtain powdery procyanidine, and packaging the procyanidine after the procyanidine is inspected to be qualified. The process is simple and easy to operate, the raw material is the pine bark which is rich in resource and low in price, and the high additional value of the pine bark is fully developed while the production cost is reduced.

The invention discloses cordyceps militaris health-care wine and a preparation method and application thereof. The health-care wine is mainly prepared by blending cordyceps militaris water extract andChinese liquor with different flavors, and main active components of the health-care wine comprise cordycepin, cordycepic acid, cordyceps adenosine and cordyceps polysaccharide. The health-care winehas the effects of resisting fatigue, protecting liver and heart, moistening lung to tonify qi, improving immunity, enhancing memory, delaying senescence, preventing and treating cardiovascular diseases and the like, and particularly has a remarkable regulating effect on sexual function decline. The content of effective components in the health-care wine is far higher than that of current commercially available products, and the health-care wine is high in quality and suitable for large-scale production.

The invention discloses a preparation method of spirulina polysaccharide. The method comprises the following specific steps: preparing raw materials, extracting a mixture, separating an extract, carrying out cooling, carrying out purifying and precipitating, washing a precipitate, carrying out solid-liquid separation, and carrying out crushing and sieving. According to the invention, damage of spirulina to a polysaccharide structure in a high-temperature drying process is avoided, the yield and the quality of the polysaccharide are improved, the alcohol consumption required by decoloration isreduced, cost is saved, and the method is more practical. The extraction amount of spirulina polysaccharide is increased, the extracted polysaccharide is used for adjuvant therapy drugs on the market,and the effects of resisting tumors, resisting radiation, promoting DNA synthesis and enhancing immunity are achieved. The yield and the quality of the polysaccharide are improved, the alcohol consumption required by decoloration is reduced, the production cost can be greatly reduced, and the quality is improved. The polysaccharide is prepared by taking fresh spirulina as a raw material, any chemical reagent is not required to be added for treatment, chemical residues are avoided, and an experimental result is closer to a required result.