1+1 clarification method

Abstract

The invention discloses a 1+1 clarification method. Coarse particles as well as macromolecular impurities such as starch, tannin, phlegmatic temperament and protein in traditional Chinese medicine extracting liquid are adsorbed and removed by utilizing the agglomeration and flocculation effects of a 1+1 clarifying agent, and the stability of a water extract is destroyed, so that the aims of refining and improving the quality of a finished product preparation are fulfilled. The 1+1 clarifying agent comprises a component A and a component B, wherein the component A is a sodium alginate solution;the component B is a chitosan modified activated carbon solution; the adding sequence of the component A and the component B is changed according to the pH value of clarifying liquid; after the firstcomponent is added, bridging connection is conducted among macromolecules with different solubility, the molecules are enlarged rapidly, and the second component performs bridging on the basis of a composite formed by the first component to enable floccules to be formed rapidly on the original basis; due to the use of a chitosan-sodium alginate copolymer, the flocculation effect is enhanced; furthermore, compared with alcohol precipitation, the 1+1 clarification method has the characteristics of low production cost, simple operation process, short production cycle and the like in the aspect of traditional Chinese medicine purification and impurity removal.

Description

technical field [0001] The invention belongs to the technical field of flocculation and clarification of Chinese herbal medicine extracts, in particular to a 1+1 clarification method. Background technique [0002] Chinese herbal medicine is a great treasure of Chinese civilization. It has a history of thousands of years and continues to this day. Generally speaking, Chinese herbal medicines cannot be taken or used directly. Whether it is ordinary people decocting Chinese herbal medicines or pharmaceutical companies preparing Chinese herbal medicine preparations, the active ingredients in the plant raw materials must be released and transferred into the solution, so that their efficacy can be conveniently taken and used, and be recognized by the public. Absorbs smoothly. We know that in addition to active ingredients, Chinese herbal medicine extracts also contain a large amount of soil, protein, polysaccharide, tannin, gum, starch, nucleic acid and harmful heavy metal ions, ...

AI Technical Summary

Problems solved by technology

Chinese patent application number 97108097.6 proposes the method with chitosan and derivative thereof and acid as clarifier, finds that effect is better than methods such as ethanol and tannin-gelatin, but still exists long clarification cycle, generation with single chitosan Disadvantages such as poor coagulation of flocs

[0006] Chinese patent application number 200610039835.3 proposes a method of using chitosan and xanthan gum in combination as a clarifying agent. This method is superior to a single chitosan clarification method, and can solve the problems of long time-consuming clarification and insufficient clarification.

However, the solubility of xanthan gum is poor, so it needs to be heated to 60°C and stirred well before use; if the stirring is not sufficient, there will be agglomeration and other phenomena

At the same time, the action of xanthan gum and chitosan not only forms the floating substance but also precipitates, so it is necessary to filter the floating substance with a screen, filter cloth, etc. and centrifuge to remove the sediment, and the operation is more cumbersome.

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