Method for extracting and separating sodium ketopropionate from acetonic acid fermentation liquid by double membrane two-step process

A technology of sodium pyruvate and pyruvic acid, applied in the separation/purification of carboxylic acid compounds, organic chemistry and other directions, can solve the problems of low yield, large pollution, long production lines, etc., to avoid low yield and avoid cumbersome steps Effect

Inactive Publication Date: 2008-06-25
NANCHANG UNIV +1
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Problems solved by technology

However, there are many difficulties in applying these methods in industrial production.
[0006] After the precursor pyruvic acid of sodium pyruvate is obtained by the above method, the obtained relatively pure pyruvic acid will be neutralized with alkali. Because the acidity of pyruvic acid is similar to acetic acid, it reacts violently with alkali and emits a large amount of However, due to the instability of pyruvate itself due to its structure, a large amount

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  • Method for extracting and separating sodium ketopropionate from acetonic acid fermentation liquid by double membrane two-step process

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Centrifugal filtration: The fermented pyruvic acid that has undergone ordinary filtration is pumped into a centrifuge for separation, and the centrifugate is input into a transfer storage tank as the raw material for the next step of ultrafiltration. (this step yield is 96.6%)

[0030] 2. Ultrafiltration and impurity removal: pump the centrifugate into the tubular ultrafiltration system for ultrafiltration and filtration, and continuously add pure water to dilute and rinse the concentrated solution to remove residual mycelium, protein, sugar, pigment and other biological macromolecules. Dialysate and ultrafiltration concentrate containing residual mycelium, protein, sugar, pigment and other biomacromolecules. The membrane material used for ultrafiltration is a polyethylene membrane with a molecular weight cut-off of 5000. The working conditions are: normal temperature, inlet pressure 3.5bar, outlet pressure 2.0bar.

[0031] 3. Concentration by nanofiltration: pump t...

Embodiment 2

[0037] 1. Centrifugal filtration: the same as in Example 1.

[0038] 2. Ultrafiltration and impurity removal: pump the filtrate of the pyruvic acid fermentation broth after centrifugal filtration into the flat ultrafiltration system for ultrafiltration and filtration, and continuously add pure water to dilute and rinse the concentrated solution to obtain ultrafiltration dialysate and ultrafiltration Concentrate. The membrane material used for ultrafiltration is a polyethersulfone membrane with a molecular weight cut-off of 10,000, and the working conditions are: normal temperature, inlet pressure 4.0bar, outlet pressure 3.0bar.

[0039] 3. Nanofiltration concentration: pump the ultrafiltration dialysate into the nanofiltration equipment for nanofiltration filtration and concentration to obtain the nanofiltration concentrate of pyruvic acid. The membrane module used for nanofiltration is a tubular membrane module, and the nanofiltration membrane material is a composite membran...

Embodiment 3

[0045] 1, centrifugal filtration: same as embodiment 1.

[0046] 2. Ultrafiltration and impurity removal: pump the pyruvate fermentation broth filtrate after centrifugation and separation of bacteria into the roll-type ultrafiltration system for ultrafiltration and filtration, and continuously add pure water to dilute and rinse the concentrated solution to obtain ultrafiltration dialysis of pyruvate liquid. The membrane material used for ultrafiltration is cellulose acetate membrane with a molecular weight cut-off of 200,000. The working conditions are: normal temperature, inlet pressure 4.5bar, outlet pressure 3.4bar.

[0047] 3. Concentration by nanofiltration: pump the ultrafiltration dialysis into the nanofiltration equipment for concentration by nanofiltration to obtain the concentrated solution of nanofiltration of pyruvic acid. The membrane module used for nanofiltration is a flat membrane module, and the nanofiltration membrane material is a polyethersulfone membrane ...

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Abstract

A method for extracting and separating the sodium pyruvate from the pyruvate fermentation broth by adopting the double membrane two-step process comprises the following steps: 1. the sodium pyruvate concentrated solution is extracted and separated through the double membrane process; 2. the sodium pyruvate concentrated solution is used for preparing the sodium pyruvate solids: the sodium pyruvate concentrated solution goes through the production steps such as the ethanol precipitation, separation of the precipitates from the mother liquors, drying, grinding, screening, inspection, finished product packaging, etc. so as to obtain the qualified sodium pyruvate solids. The invention has the advantages of short production process, high product purity, high utilization ratio, high automation degree, few contamination caused to the environment, low production cost, etc., and is especially suitable for the industrialized large-scale production of the sodium pyruvate.

Description

technical field [0001] The invention relates to a method for separating and extracting sodium pyruvate from pyruvate fermentation broth, in particular to a method for extracting and separating sodium pyruvate from pyruvate fermentation broth by a double-membrane two-step method. Background technique [0002] Sodium pyruvate is the sodium salt of pyruvic acid. Pyruvate is a keto acid containing three carbons, a colorless liquid with an odor similar to acetic acid, an important intermediate metabolite in the process of sugar metabolism, and a precursor of many useful compounds. Therefore, it is widely used in chemical industry, It has a wide range of applications in industry and scientific research such as pharmaceuticals and agrochemicals. Since the structure of pyruvate contains two linked carbonyl groups, which leads to the instability of its structure, the pyruvate group usually exists in the form of pyruvate. At present, the common preparation me...

Claims

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Application Information

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IPC IPC(8): C07C59/19C07C51/43
Inventor 李建科熊国平邹威寥观顺徐昶魏才学赵南
Owner NANCHANG UNIV
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