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Method for eliminating antigen from animal fur

A technology for antigenic substances and animal skins, which can be used in pharmaceutical formulations, unknown raw materials, and medical preparations containing active ingredients, etc. It can solve the problems of uncontrollability, single target, and complex decellularization methods, and achieve significant economic benefits. , The method is simple and easy, and the effect of good biocompatibility

Active Publication Date: 2005-01-26
JIANGYIN BENXIANG BIOTECHOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] (1) The decellularization method is complicated and not controllable;
[0011] (2) Not suitable for industrial production;
[0012] (3) Single goal

Method used

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  • Method for eliminating antigen from animal fur
  • Method for eliminating antigen from animal fur
  • Method for eliminating antigen from animal fur

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Select a healthy pig, slaughter it, peel off its skin, take 100kg of fresh pigskin, put it into the drum, add 220kg of water with a temperature of 28°C, 8kg of penetrant JFC, cover the door of the drum, rotate it for 60min, and control it. Dry waste. Then add 220kg of water at a temperature of 28°C, cover the drum door, and rotate for 60 minutes. Repeat this operation 3 times. Then, it is fully washed with water and spin-dried with a centrifuge.

[0047] (2) Take out the pigskin from the centrifuge, put it into a supercritical fluid processor, add 8 kg of Pingpinga O, 5 kg of washing powder and 3 kg of penetrant JFC, and treat it for 60 minutes at a temperature of 5°C and a pressure of 9.0 MPa.

[0048] (3) Take out the pigskin from the supercritical fluid processor, put it into the drum, add 220kg of normal temperature water, cover the door of the drum, rotate for 60min, and dry the waste liquid. Then add 220kg of normal temperature water, cover the drum door, a...

Embodiment 2

[0053] (1) Select a healthy goat, slaughter it, peel off its skin, take 100kg of fresh goat skin, put it into the drum, add 350kg of water at a temperature of 32°C, and 16kg of penetrating agent JFC, cover the drum door, and rotate it for 75min. Dry waste. Then add 350kg of water at a temperature of 32°C, cover the drum door, and rotate for 75 minutes. Repeat this operation 4 times. Then, it is fully washed with water and spin-dried with a centrifuge.

[0054] (2) Take out the goat skin from the centrifuge, put it into a supercritical fluid processor, add 12kg of Pingpingjia, 7.5kg of washing powder and 6.0kg of penetrant JFC, and treat it for 150min at a temperature of 22°C and a pressure of 18.0Mpa.

[0055] (3) Take out the goat skin from the supercritical fluid processor, put it into the drum, add 350kg of normal temperature water, cover the drum door, rotate for 75min, and dry the waste liquid. Then add 350 kg of normal temperature water, cover the drum door and rotate...

Embodiment 3

[0060] (1) Select healthy cattle, slaughter them, peel off their skins, take 100kg of fresh cattle hides, put them into the drum, add 500kg of water at a temperature of 36°C, and 30kg of penetrant JFC, cover the drum door, rotate for 120min, and control Dry waste. Then add 500kg of water at a temperature of 36°C, cover the drum door, and rotate for 120 minutes. Repeat this operation 5 times. Then, it is fully washed with water and spin-dried with a centrifuge.

[0061] (2) Take out the yellow cowhide from the centrifuge, put it into a supercritical fluid processor, add 20kg of Pingpingjia, 30kg of washing powder and 10kg of penetrant JFC, and treat it for 240min at a temperature of 40°C and a pressure of 25.0Mpa.

[0062] (3) Take out the yellow cowhide from the supercritical fluid processor, put it into the drum, add 500kg of normal temperature water, cover the drum door, rotate for 120min, and dry the waste liquid. Then add 500kg of normal temperature water, cover the dru...

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Abstract

The invention discloses a method for removal of antigen in the animal fur. It is characterized in that it utilizes the supercritical fluid processor and chemical agent. The invention can remove the antigen of the animal fur rapidly, effectively and completely without changing the three dimensional histological structure of the animal fur. The animal fur after the treatment can adapt to the needs of multiple medical applications

Description

1. Technical field [0001] The invention relates to a method for removing antigenic substances in animal skin, belonging to the field of biomedical material processing. 2. Background technology [0002] We know that skin collagen is a large family of collagens, mainly type I and type III collagens, which are the main components of structural tissues in mammals and constitute about 30% of the protein in the human body. According to reports, so far, 18 or 19 collagen types have been discovered (Yan Longfei, Sun Zhirong "Protein Molecular Structure". Beijing: Tsinghua University Press, 1999). In a nutshell, the biological properties of collagen are mainly manifested in the following four aspects, namely: (1) low antigenicity; (2) characteristics of being absorbed in the human body; (3) inducing cell proliferation and growth; (4) promoting Platelets clot. (Dan Weihua, Wang Kunyu, Zeng Rui, etc., The medical application and development prospect of collagen, "Biomedical Engineeri...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61L15/32A61L27/24A61L27/60
Inventor 但卫华廖隆理李志强陈敏王坤余曾睿但年华
Owner JIANGYIN BENXIANG BIOTECHOLOGY
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