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Bilobalide k and complex thereof, preparation method and use for the same

A technology of ginkgolides and complexes, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve good pharmacological activity, reduce the degree of nuclear dissolution, and reduce the effect of softening focus

Active Publication Date: 2007-02-28
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no ginkgolide K preparation on the market at home and abroad

Method used

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  • Bilobalide k and complex thereof, preparation method and use for the same
  • Bilobalide k and complex thereof, preparation method and use for the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Example 1. A preparation method of ginkgolide K, the steps of which are as follows: add ginkgolide B to an alkaline aqueous solution, heat and dissolve in a water bath, and keep warm; after testing that the ginkgolide B is basically completely transformed, then adjust the pH value with an acidic aqueous solution Until the solution becomes acidic, let it stand still, filter to obtain a precipitate, take the precipitate and wash it with water, then dissolve it with an organic solvent, concentrate, and recrystallize until the purity reaches more than 90%.

Embodiment 2

[0081] Example 2. A preparation method of ginkgolide K, the steps of which are as follows: add ginkgolide extract containing ginkgolide B to a mixed solution of alkaline water and alcohol, heat and dissolve in a water bath, and keep warm; after testing, ginkgolide B is basically After the transformation is complete, adjust the pH value with an acidic aqueous solution until the solution is acidic, let it stand still, and centrifuge to obtain a precipitate. The precipitate is washed with water, dissolved in an organic solvent, concentrated, and recrystallized until the purity reaches more than 90%.

Embodiment 3

[0082] Example 3. A preparation method of ginkgolide K, the steps of which are as follows: add ginkgolide B to a water-alcohol mixed solution, heat and dissolve in a water bath, and keep warm; after testing that the ginkgolide B has basically transformed completely, concentrate and crystallize, and obtain The crystals are then dissolved in an organic solvent, concentrated, and recrystallized until the purity reaches more than 90%.

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Abstract

The invention discloses a preparing method and application of bilobalide K with general formula as (I), which is characterized by the following: G is alkaline material; possessing stability and water-solubility.

Description

technical field [0001] The invention relates to a ginkgolide substance and a compound thereof; in particular, a ginkgolide K and a compound thereof, and also relates to a preparation method and application of the ginkgolide K and a compound thereof. Background technique [0002] Ginkgolide is an effective substance extracted from the Chinese herbal medicine Ginkgo biloba. The substance can be further subdivided into ginkgolide A, B, C, bilobalide, etc. in terms of structure. The extraction method of ginkgolide has been described in detail. Bibliographical reports, for example, people such as Li Xingang introduced the laboratory extraction method of ginkgolide (seeing Li Xingang etc., the laboratory extraction method research of ginkgolide in ginkgo leaf, Chinese Journal of Pharmaceutical Industry 1998 No. 1 issue), Chinese patent Document CN1195665A introduces the extraction method of ginkgolide and the preparation containing ginkgolide. The method is to ...

Claims

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Application Information

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IPC IPC(8): C07D493/22A61K31/365A61P9/10A61P7/02A61P37/06A61P29/00A61P37/08A61P43/00
Inventor 肖伟戴翔翎凌娅李明慧丁岗章晨峰
Owner JIANGSU KANION PHARMA CO LTD
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