Application of general alkaloid of bocconia cordata for treating schistosomiasis

A technology for schistosomiasis control and total alkaloids, which is applied in the fields of snail eggs, schistosomiasis cercariae and schistosomiasis control, and killing oncomelania, which can solve the problems of environmental pollution, manual mollusc killing, labor-intensive, time-consuming and expensive, and poisonous.

Inactive Publication Date: 2007-05-09
长沙世唯科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Manual mollusc control is labor-intensive, time-consuming and expensive, it is poisonous to humans, fish, livestock, etc., and it is easy to cause environmental pollution
[0012] But at present, there are no related reports and

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Take the original medicinal material of Boluohui fruit pods, remove impurities, weigh 20kg, add acid water with sulfuric acid to adjust the pH value to 2-3, and extract twice, each time for 3 hours, and the dosage is 8 times and 6 times respectively. Solid-liquid separation, the filtrate is adjusted to a pH value of 11 with sodium hydroxide, allowed to stand for 24 hours, precipitated, filtered, and dried to obtain not less than 15% boron of total alkaloids.

Embodiment 2

[0055] Take the total alkaloids obtained in Example 1, dissolve them in 90% ethanol, add sulfuric acid under stirring, let stand to crystallize, refine, and dry to obtain no less than 60% of the total alkaloid sulfates of boluohui, water Quantitative adjustment of soluble starch can obtain 60% boluohui total alkaloid sulfate powder.

[0056] Take the above-mentioned powder and carry out the tests of killing snails, killing snail eggs and killing cercariae of schistosomiasis according to the method of the test example.

[0057] In the snail killing test, when the concentration is 5.0mg / L, the temperature is 25°C, and the snails are soaked for 48-72 hours, the mortality rate of the snails is 99-100%.

[0058] In the mollusc-egg test, when the concentration is 5 mg / L, soak for 72 hours, and the hatching rate of snail eggs is 0-5%.

[0059] In the test of killing schistosome cercariae, cercariae were exposed to 5 mg / l solution for 60 minutes and 100% died

Embodiment 3

[0061] Take the total borate alkaloids obtained in Example 1, dissolve them in 90% ethanol, add boric acid under stirring, stand for crystallization, refine, and dry to obtain not less than 85% borate total alkaloid borates. Quantitative adjustment of water-soluble starch can obtain 85% Boluohui total alkaloid borate powder.

[0062] Take the above-mentioned powder and carry out the tests of killing snails, killing snail eggs and killing cercariae of schistosomiasis according to the method of the test example.

[0063] In the snail killing test, when the concentration is 2.5mg / L, the temperature is 25°C, and the snails are soaked for 72-96 hours, the mortality rate of the snails is 99-100%.

[0064] In the mollusc-egg test, when the concentration is 5 mg / L, soak for 72 hours, and the hatching rate of snail eggs is 0-4%.

[0065] In the test of killing schistosome cercariae, cercariae were exposed to 5 mg / l solution for 60 minutes and 100% died

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PUM

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Abstract

An application of the alkaloid of pink plumepoppy in preventing and treating schistosomiasis and killing on comelania and its ova and Japanese schistosome cercaria is disclosed.

Description

technical field [0001] The invention relates to the application of the total alkaloids and salts thereof obtained from Bouillaba plants to kill oncomelania, snail eggs, cercariae of Schistosoma japonicum and prevent and treat schistosomiasis. Background technique [0002] Schistosomiasis is an endemic disease caused by adult worms of schistosomiasis parasitizing the human body. It is mainly prevalent in 73 countries in Asia, Africa, and Latin America, and the number of patients is about 200 million. Human schistosomes are divided into four types: S. japonicum, S. haematobium, S. mansoni and S. intetcalatum. Schistosomiasis japonicum is distributed in China, Japan, the Philippines, Indonesia, Thailand and other Asian regions and countries; Schistosomiasis mansoni is distributed in Asia, the Middle East, India and other regions; Schistosoma intercalatum is distributed in West Central Africa, Zaire, Cameroon and other countries . Only Schistosomiasis japonicum (schistosomiasi...

Claims

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Application Information

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IPC IPC(8): A61K36/66A61P33/12
CPCY02A50/30
Inventor 曾建国
Owner 长沙世唯科技有限公司
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