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Use of cape-jasmine extract in treatment of chronic hepatitis B

A technology of chronic hepatitis B and gardenia extract, which is applied in the field of traditional Chinese medicine and can solve problems such as unseparated

Inactive Publication Date: 2007-06-20
CHINA JAPAN FRIENDSHIP HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, the effective part extract of Gardenia jasminoides for the treatment of chronic hepatitis B has not been isolated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Grind the gardenia jasmine, soak it with 30% ethanol at 40°C to obtain an extract, centrifuge the extract to remove slag, concentrate the supernatant under reduced pressure to recover ethanol, add 95% ethanol until the alcohol content reaches 60%, and precipitate , let stand overnight. After filtration to remove sedimentation, the recovered ethanol has almost no alcohol smell, and is diluted with water according to the ratio of 1 gram of crude drug to 10 ml, to obtain the column liquid.

[0022] Take AB-8 macroporous adsorption resin, pack it into a column, and pass the above extract through the AB-8 macroporous adsorption resin column according to the ratio of crude drug resin to 1:2, and then use 0.5 times the volume of the sample after passing through the resin column. Pour water into the column until the effluent is basically colorless. After flushing the column with 20% ethanol, the eluent was decompressed to recover the ethanol extract.

[0023] As determined by...

Embodiment 2

[0025] Grind gardenia, soak twice in 70% ethanol at 60°C, more than 3 hours each time, combine the extracts, centrifuge the extracts to remove slag, concentrate the supernatant under reduced pressure to recover ethanol, add 95% ethanol to contain alcohol The amount reached 80% of the precipitate and stood overnight. After filtration to remove sedimentation, the recovered ethanol has almost no alcohol smell, and is diluted with water according to the ratio of 1 gram of crude drug to 10 ml, to obtain the column liquid.

[0026] Take X-5 macroporous adsorption resin, pack it into a column, and pass the above extract through the AB-8 macroporous adsorption resin column according to the ratio of crude drug resin to 1:2, and then use 2 times the volume of the sample after it has passed through the resin column. Pour water into the column until the effluent is basically colorless. After flushing the column with 50% ethanol, the eluent was decompressed to recover the ethanol extract....

Embodiment 3

[0028] Crush, take 50% ethanol and soak twice at 50°C, more than 3 hours each time, and combine the extract, centrifuge the extract to remove slag, concentrate the supernatant under reduced pressure to recover ethanol, add 95% ethanol until the alcohol content reaches 70% precipitated and left to stand overnight. After filtration to remove sedimentation, the recovered ethanol has almost no alcohol smell, and is diluted with water according to the ratio of 1 gram of crude drug to 10 ml, to obtain the column liquid.

[0029] Take D101 macroporous adsorption resin, pack it into a column, and pass the above extract through the AB-8 macroporous adsorption resin column according to the ratio of crude drug resin to 1:2. Punch the column (about 5 times the column volume) until the effluent is basically colorless. After flushing the column with 30% ethanol, the eluent was decompressed to recover the ethanol extract. The extract was subjected to silica gel column chromatography and el...

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PUM

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Abstract

An application of capejasmine fruit extract containing iridoid glycoside (40% or more) and jasminodin (25% or more) in treating chronic hepatitis B and repairing liver injury is disclosed.

Description

technical field [0001] The invention relates to a new application of gardenia extract, in particular to application of gardenia extract in treating chronic hepatitis B and protecting liver damage, and belongs to the field of traditional Chinese medicine. Background technique [0002] Viral hepatitis is a common disease worldwide, and my country is an epidemic "hardest hit area". Various types of viral hepatitis seriously threaten the health of Chinese people. Hepatitis C is the most common in western countries, but hepatitis B is the most prevalent in our country. According to statistics, there are currently 350 million chronic hepatitis B virus (hepatitis B virus, HBV) infected people in the world, about 120 million infected people in my country, and about 30 million patients with abnormal liver function caused by hepatitis B. The infection rate of hepatitis C is also about 3.2%. In addition, chronic viral hepatitis is also closely related to the occurrence of primary live...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P1/16A61P31/20A61K131/00
Inventor 赵世萍付桂香张德权丛笑潘琳张岚董晞张韫张远春
Owner CHINA JAPAN FRIENDSHIP HOSPITAL
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