Liposome-containing radiographic contrast medium and preparation method thereof

Abstract

A liposome-containing X-ray radiopaque dye comprising a water soluble iodide compound contained in a water phase inside and outside lipid membranes. The liposomes are produced by mixing lipid membrane components for constituting lipid membranes with carbon dioxide of supercritical or subcritical condition in the presence of at least one compound having a hydroxyl or polyalkylene oxide group. The obtained X-ray radiopaque dye containing these liposomes does not contain any toxic solvents, such as chlorinated solvents, so that high safety can be ensured.

Description

technical field [0001] The invention relates to a radiographic contrast agent comprising liposomes and a preparation method thereof, in particular to a radiographic contrast agent comprising liposome vesicles. The calcium contrast agent is obtained by combining lipid membrane components with supercritical or subcritical carbon dioxide at least A mixture is formed in the presence of a compound containing a hydroxyl group or a polyoxyalkylene group, and the non-ionic iodine compound is efficiently and stably encapsulated in the liposome. Background of the invention [0002] The use of X-ray inspection and diagnosis is the core of today's medical imaging diagnosis. So-called hard tissues such as bones and teeth absorb X-rays efficiently, so high-contrast X-ray images can be obtained. Conversely, the differences in X-ray absorption among different soft tissues are relatively small, making it difficult to obtain high-contrast images. In such cases, contrast agents are often use...

AI Technical Summary

Problems solved by technology

It is further pointed out that because liposomes are almost always trapped in the reticuloendothelial tissue system after being introduced into the organism, such as the liver or spleen, the desired effect has not been achieved (Cancer Res., 43, 5328 (1983))

Images