Unlock instant, AI-driven research and patent intelligence for your innovation.

Cosmetic compositions containing substituted amine derivatives

Inactive Publication Date: 2002-02-28
UNILEVER HOME & PERSONAL CARE USA DIV OF CONOPCO IN C
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0030] Humectants of the polyhydric alcohol type may also be employed as cosmetically acceptable carriers in compositions of this invention. The humectant aids in increasing the effectiveness of the emollient, reduces scaling, stimulates removal of built-up scale and improves skin feel. Typical polyhydric alcohols include glycerol, polyalkylene glycols and more preferably alkylene polyols and their derivatives, including propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1,3-butylene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and mixtures thereof. For best results the humectant is preferably propylene glycol or sodium hyaluronate. The amount of humectant may range anywhere from 0.5 to 30%, preferably between 1 and 15% by weight of the composition.
[0041] The preferred ester for use in the present invention is selected from retinyl palmitate, retinyl acetate and retinyl propionate, because these are the most commercially available and therefore the cheapest. Retinyl ester is also preferred due to its efficacy.

Problems solved by technology

A frequent, undesirable skin condition is "oily skin," the condition which results from the excessive amount of sebum on the skin.
Oily skin is associated with a shiny, undesirable appearance and a disagreeable tactile sensation.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cosmetic compositions containing substituted amine derivatives
  • Cosmetic compositions containing substituted amine derivatives
  • Cosmetic compositions containing substituted amine derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0051] Compounds A through E were tested for their potential to suppress sebum expression, alone or in the presence of a retinoid.

[0052] Secondary cultures of human sebocytes obtained from an adult male were grown in 48-well tissue culture plates (Costar Corp.; Cambridge, MA) or 96- well tissue culture plates (Packard Co.; Meriden, CT) until confluent.

[0053] Sebocyte growth medium consisted of Clonetics Keratinocyte Basal Medium (KBM) supplemented with 14 .mu.g / ml bovine pituitary extract, 0.4 .mu.g / ml hydrocortisone, 5 .mu.g / ml insulin, 10 .mu.g / ml epidermal growth factor, 1.2 .times.10-10 M cholera toxin, 100 units / ml penicillin, and 100 .mu.g / ml streptomycin.

[0054] All cultures were incubated at 37.degree. C. in the presence of 7.5% CO.sub.2. Medium was changed three times per week.

[0055] On the day of experimentation, the growth medium was removed and the sebocytes washed three times with sterile Dulbecco's Modified Eagle Medium (DMEM; phenol red free). Fresh DMEM was added to e...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Fractionaaaaaaaaaa
Fractionaaaaaaaaaa
Molar densityaaaaaaaaaa
Login to View More

Abstract

Cosmetic methods and compositions containing selected substituted secondary amine aromatic compounds. The inventive compositions provide control of sebum secretion from sebocytes, improved oil control and improved feel, and prevent shine and stickiness.

Description

[0001] Cosmetic methods and compositions containing secondary amine aromatic derivatives. BACKGROUND OF THE INVENTION[0002] A frequent, undesirable skin condition is "oily skin," the condition which results from the excessive amount of sebum on the skin. Sebum is skin oil which is produced by sebocytes (cells of the sebaceous glands in the skin) and is then secreted to the skin surface. Oily skin is associated with a shiny, undesirable appearance and a disagreeable tactile sensation. Oily skin affects various age groups. Cosmetic products which provide sebum control are highly desirable.[0003] The present invention includes, in its first aspect, a cosmetic composition comprising:[0004] (i) from about 0.001% to about 50% of a substituted secondary amine aromatic derivative 1[0005] selected from the group consisting of compounds A, B, C, D and E as follows:1 Compound R R' A 2 3 B 4 5 C 6 7 D 8 9 E 10 11[0006] and[0007] (ii) a cosmetically acceptable vehicle.[0008] The present inventio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K6/00A61K8/30A61K8/00A61K8/33A61K8/35A61K8/41A61K8/46A61K8/49A61K8/67A61K31/135A61Q5/00A61Q17/04A61Q19/00
CPCA61K8/33A61K8/35A61K8/41A61K8/46A61K8/4913A61K8/4926A61K8/498A61K8/671A61Q5/00A61Q5/008A61Q5/02A61Q19/00A61Q19/008
Inventor BAJOR, JOHN STEVENPOCALYKO, DAVID JOSEPH
Owner UNILEVER HOME & PERSONAL CARE USA DIV OF CONOPCO IN C
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More