p53 Inhibitors and therapeutic use of the same

a technology of p53 and inhibitors, which is applied in the direction of biocide, heterocyclic compound active ingredients, drug compositions, etc., to achieve the effect of reducing or eliminating p53-dependent neuronal death, reducing or eliminating neuronal damag
US20050222224A1Inactive Publication Date: 2005-10-06THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
Publication Date
2005-10-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The therapeutic use of temporary p53 inhibitors in the treatment of p53-mediated diseases, conditions, and injuries is disclosed.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of provisional application Ser. No. 60 / 117,881, filed Jan. 29, 1999.FIELD OF THE INVENTION

[0002] The present invention relates to temporary p53 inhibitors and their use in therapy, for example, in cancer treatment, in modifying tissue response to a stress, and in modifying cell aging. More particularly, the present invention relates to compounds having the ability to effectively and temporarily inhibit p53 activity, and that can be used therapeutically, alone or in conjunction with a therapy, like chemotherapy or radiation therapy during cancer treatment, to treat a disease or condition where temporary inhibition of p53 activity provides a benefit. Examples of compounds that temporarily inhibit p53 activity and can be used therapeutically have the following general structural formulae (I) through (IV):

[0003] and pharmaceutically acceptable salts and hydrates thereof. BACKGROUND OF THE INVENTION [00...

Claims

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