Peptides with wound healing activity

a technology of peptides and wounds, applied in the field of wound healing, can solve the problems of cosmetically undesirable consequences, scarring and impairment of function, and the healing of wounds still presents a considerable challenge to the clinician, and achieves the effects of stimulating the immune system, stimulating pituitary/hypothalamus activity, and promoting wound healing
US20050250685A1Inactive Publication Date: 2005-11-10ZAVERI CHANDA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ZAVERI CHANDA
Publication Date
2005-11-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

A number of peptides of from 28 to 44 amino acids, including therein a sequence of L-K-E-K-K (SEQ ID NO: 1) have a physiological activity that can be wound healing activity, immunostimulant activity, or growth factor activity. The peptides can be linear or circular, and if linear, the amino terminus can be optionally acetylated. The invention also includes nucleic acids encoding these peptides, vectors incorporating these nucleic acid sequences, and host cells transfected with these vectors, as well as methods for producing these peptides by culturing these host cells and purifying these peptides. The invention further includes pharmaceutical compositions and methods for using these peptides.
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Description

CROSS-REFERENCES

[0001] This application is a divisional application of application Ser. No. 09 / 879,666, by Chanda Zaveri, entitled “Peptides with Wound Healing Activity” (as amended), filed Jun. 12, 2001, which in turn claimed priority from Provisional Application Ser. No. 60 / 211,859 by Chanda Zaveri, filed Jun. 14, 2000, entitled “Peptides with Physiological Activity,” both of which are incorporated herein in their entirety by this reference.BACKGROUND OF THE INVENTION

[0002] This invention is directed to peptides with various physiological activities, particularly wound healing.

[0003] Wound healing is a complex biological process that differs according to the wound type: acute or chronic. The principal elements of wound repair are the immediate events of hemostasis and stimulus for inflammation, then inflammation and cell proliferation and migration, then followed by molecular synthesis, collagen polymerization and cross-linking, remodeling, and wound contraction. Inflammation i...

Claims

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