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5results about "Angiogenin" patented technology
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Sirna inhibiting expression of amyloid precursor protein (APP) gene, drug, and use
PendingEP4768587A1Organic active ingredientsNervous disorderOligonucleotideAmyloid Protein Precursor
The present invention provides siRNA, peptide oligonucleotide drugs, and their applications for suppressing the expression of the amyloid precursor protein (APP) gene in human cells. The siRNA exhibits potent activity in inhibiting APP expression. Through appropriate modifications, its ability to silence the target is enhanced while reducing off-target activity. The described siRNA and its conjugates hold promise for clinical application in the prevention and treatment of diseases associated with the APP target, including cerebral amyloid angiopathy (CAA), early-onset familial Alzheimer's disease (EOFAD), or Alzheimer's disease (AD).
Owner:BEBETTER MED INC
Compositions and methods for NK cell differentiation
Owner:UMOJA BIOPHARMA INC
Peptides and compositions for treatment of joint damage
The present invention provides new protease resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.
Owner:NOVARTIS AG
Multispecific fusion proteins targeting angiogenic and inflammatory factors
PCT designated stageWO2026103317A1Hybrid immunoglobulinsAntibody mimetics/scaffoldsAntigenInflammatory factors
A fusion protein or an antigen-binding fragment or domain thereof comprises a pair of heavy chain and light chain of a VEGF antibody, a pair of heavy chain and light chain of an IL-6 or IL-6R antibody, and a single domain antibody or a binding polypeptide directed against Ang-2 that is linked to each of the VEGF antibody and the IL-6 or IL-6R antibody.
Owner:F HOFFMANN LA ROCHE INC +1