36 results about "Growth factor activity" patented technology

The present invention relates to a growth factor-mimicking peptide having an activity of the growth factor, and a composition and a method for improving skin conditions or for treating a wound using the same. The growth factor-mimicking peptides of this invention have identical functions or actions to natural-occurring human growth factor, and much better stability and skin penetration potency than natural-occurring growth factor. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding growth factor activities. In addition, excellent activity and stability of the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.

The invention discloses a preparation method of a multi-growth-factor slow release coating of a titanium and titanium alloy surface. According to the method, a plurality of layers of coatings containing nanoparticles of growth factors are prepared on the titanium surface by taking the nanoparticles as a growth factor carrier and charged high molecular thin films as a medium. The nanoparticles included in the coating are prepared by mixing polycation solution containing dopamine of certain concentration with polyanion solution containing the growth factors. The nanoparticles have good dispersibility, can protect the activity of the growth factors and are easy to fix on the surface of a material. By controlling the electric property of the nanoparticles and the high molecular thin films, nanoparticles carrying with different factors are embedded between the high molecular thin films. By adjusting the loading quantity and the loading sequence of different nanoparticles and the thickness of the coatings, effective control over release speed, release quantity and release sequence of the various growth factors can be realized.

The invention relates to a collagen-based bilayer membrane material for directional release of growth factors and a manufacturing method of the collagen-based bilayer membrane material. The collagen-based bilayer membrane material is prepared from collagen, the growth factors, fibrinogen and thrombin; a dense layer collagen membrane and a loose layer collagen membrane are prepared, and the dense layer collagen membrane and the loose layer collagen membrane are bonded by virtue of fibrous protein, so that a bilayer membrane structure is constituted. The growth factors can be loaded on the surface of the membrane by a dosage of 1-10000ng of the growth factors per square centimeter; preferably, the growth factors are loaded on the bilayer membrane by a dosage of 30ng per square centimeter; and preferably, average thickness of the bilayer membrane is 1-5mm. The material has a bidirectional controlled-release effect on the loaded growth factors, so that directional release of the growth factors is achieved and the material can act on target tissues; and the material is applicable to restorative treatment of diseased and defective tissues. The growth factors, which are loaded on the bilayer collagen membrane prepared by the invention and have a targeted release effect, can be released to the target tissues in a directional mode and activity of the growth factors can be kept; and the bilayer membrane material can be used for guiding and inducing regeneration and repair of tissues.