Cross-frame object reconstruction for image-based cytology applications

Active Publication Date: 2007-06-14
CYTYC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0029]FIG. 11 is a schematic of a series of image data frames in which partially contained

Problems solved by technology

In one method, the attributes of one of the complementary object portions may either not be analyzed or may be inaccurately analyzed as a normal step in processing the biological specimen.
However, becau

Method used

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  • Cross-frame object reconstruction for image-based cytology applications
  • Cross-frame object reconstruction for image-based cytology applications
  • Cross-frame object reconstruction for image-based cytology applications

Examples

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Example

[0033] Referring to FIG. 2, a biological screening system 10 constructed in accordance with one preferred embodiment of the present invention is described. The system 10 is configured for presenting a biological specimen 12 located on a microscope slide 14 (best shown in FIG. 3) to a technician, such as a cytotechnologist, who can then review objects of interest (OOIs) located in the biological specimen 12. The OOIs are arranged in a number of fields of interest (FOIs) (one of which is illustrated in FIG. 4) that cover portions of the slide 14, so that the cytotechnologist's attention can be subsequently focused on OOIs within the FOIs, rather than slide regions that are not pertinent. The slide 14 is provided with fiducial marks 16, the function of which will be described in further detail below.

[0034] Although the system 10 can be used to present any biological specimen (or even a non-biological specimen, such as a computer chip) that requires further review, the system 10 lends ...

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Abstract

Methods, computer software, and systems for analyzing a biological specimen (e.g., a cytological specimen) on a slide is provided. Magnified image data frames of the biological specimen are taken at different locations on the slide. An object that is not entirely contained within at least one of the image data frames is identified, and complementary portions of the object respectively located in different ones of the image data frames are matched. A fully integrated object is created from the matched object portions. Attributes of the integrated object are then analyzed.

Description

FIELD OF THE INVENTION [0001] The field of the present invention generally relates to methods and systems for diagnostically imaging specimens, such as cytological specimens. BACKGROUND OF THE INVENTION [0002] In the medical industry, there is often a need for a laboratory technician, e.g., a cytotechnologist, to review a cytological specimen for the presence of specified cell types. For example, there is presently a need to review a cervico-vaginal Papanicolaou (Pap) smear slides for the presence of malignant or pre-malignant cells. Since its introduction over fifty years ago, Pap smears have been a powerful -tool for detecting cancerous and precancerous cervical lesions. During that time, the Pap smear has been credited with reducing mortality from cervical cancer by as much as 70%. This once precipitous drop in the death rate has slowed however, and the mortality rate in the United States for this preventable disease has remained virtually constant, at about 5,000 per year since ...

Claims

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Application Information

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IPC IPC(8): G06K9/00
CPCG06V20/693
Inventor DUTTA-CHOUDHURY, PAUL
Owner CYTYC CORP
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