Enhancement of mammalian embryo development

a technology for mammalian embryos and embryos, applied in the field of enhancement of mammalian embryo development, can solve the problems that wild-type embryos transferred cannot implant in female mice deficient in cox-2, and achieve the effects of enhancing in vitro embryo development, enhancing in vivo implantation potential, and complete hatching of embryos
US20090011496A9Inactive Publication Date: 2009-01-08BOARD OF RGT THE UNIV OF TEXAS SYST
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BOARD OF RGT THE UNIV OF TEXAS SYST
Publication Date
2009-01-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

A method of enhancing in vitro development of a mammalian embryo is disclosed which comprises supplementing the culture medium with a prostaglandin, or a prostaglandin analog, in an amount effective to promote complete hatching of the embryo (i.e., freeing of the embryo from the zona pellucida). The quality of human blastocysts is enhanced in vitro by culturing with a prostacyclin agonist, Iloprost. The in vivo implantation potential and live birth potential of an in vitro fertilization embryo is thereby enhanced and establishment of a viable pregnancy is facilitated.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation-in-part of PCT / US04 / 029167 filed Sep. 8, 2004, from which priority under 35 U.S.C. §120 is claimed. This application also claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application No. 60 / 708,291 filed Aug. 15, 2005. The disclosures of those applications are hereby incorporated herein by reference.STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

[0002] This invention was made in part, with funding from the National Institute of Child Health and Human Development (NICHD), Contract No. HD01277. Accordingly, the United States Government has certain rights in this invention.BACKGROUND OF THE INVENTION

[0003] 1. Field of the Invention

[0004] The present invention generally relates to compositions and methods for in vitro culturing of mammalian embryos and for enhancing achievement of pregnancy after implantation of the cultured embryo in the uterus of a suitable mammali...

Claims

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