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Method for treatment of laminitis in animals

a technology for laminitis and animals, applied in the field of laminitis in animals, can solve the problems of reducing blood flow through the dorsal lamina, reducing the blood flow, and rotating or sinking of the distal phalanx within the hoof capsule, so as to prevent further laminar tearing or displacement of the distal phalanx, and reducing the pull on the distal phalanx

Active Publication Date: 2009-01-29
VETMED THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This approach reduces shear forces on the lamina, preserves laminar perfusion, and allows the hoof to reestablish normal orientation, potentially preventing chronic laminitis and promoting recovery without the need for invasive surgery, as demonstrated by improved mobility and reduced pain in treated horses.

Problems solved by technology

This inflammation may lead to separation of the epidermal lamina from the dermal lamina associated with the distal phalanx (coffin bone) often resulting in the rotation or sinking of the distal phalanx within the hoof capsule.
First, the tightening may compromise the blood flow through the dorsal lamina.
The decrease in blood flow may cause decreased laminar perfusion.
With a decrease in laminar perfusion lamina tissue is deprived of nutrients and is weakened and more subject to tearing.
Second, the tightening of the deep digital flexor tendon on the palmar aspect of the digital phalanx creates a force which pulls the laminar membrane away from the digital phalanx or hoof wall.
The pull of the deep digital flexor tendon on the distal phalanx often causes the distal phalanx to become displaced as the opposing force of the laminar attachment is impaired.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example no.1

EXAMPLE NO. 1

[0034]An 11 year old Tennessee Walking Horse with a history of laminitis was experiencing an acute exacerbation of the laminitis condition (Obel Grade 4). Botulinum toxin (Botox) was reconstituted into 100 units per 2cc of normal saline. The skin overlying the flexor muscles of the fore legs was prepped with isopropyl alcohol. Using EMG guidance, 25 units of botulinum toxin was injected into 8 sites of the flexor digitorum profundus of each forelimb for a total of 400 units. The horse tolerated the procedure well with no immediate adverse effects noted. The horse was monitored over the next 12 weeks. Within 2 weeks the horse showed a marked improvement in it's ability to stand and ambulate. The horse has subsequently returned to functional use to the level of pasture comfort and occasional riding at all gaits.

example no.2

EXAMPLE NO. 2

[0035]An eight year old stallion quarter horse was experiencing severe laminitis in two legs (Obel Grade 4). In leg 1 the deep digital flexor tendon was surgically cut utilizing accepted procedures and techniques. Redding shoes were applied at a 15 degree angle. In leg 2 utilizing clean technique and EMG guidance a total of 400 units of Botulinum Toxin Type A diluted into 8 cc of normal saline was injected into 8 separate sites within the flexor digitorum profundus. Redding shoes were applied at 15 degree angles. The horse underwent pre and post procedure venograms with no initial difference noted between the legs. The horse tolerated both procedures well and was monitored over the subsequent 5 weeks. The horse experienced a recovery from an Obel grade of 4 to an Obel grade of 3 with repeat venograms showing recovery of venous flow in both digits. Comparison between the two legs revealed a more rapid return to normal venous patterns in the limb receiving surgical transe...

example number 3

[0036]A 21 year old gelding quarter horse suffered a traumatic injury to the right fore carpus. Radiograph showed disruption of the normal arrangement of the carpal bones as well as severe swelling of the palmar aspect of the carpus. He was unable to extend the carpus in the non-weight bearing limb. This horse was diagnosed with traumatic disruption of the palmar ligaments of carpal bones including the accessory ligament of the deep digital flexor tendon. In an effort to prevent the development of laminitis in the contra-lateral limb, the horse received botulinum toxin 200 units (botox) injected into the deep digital flexor muscle as described above. The horse tolerated the procedure well. A Redden “Ultimate” shoe was also placed. The horse was monitored over the next 7 months. At one week and again at one month examination found no clinical evidence of laminitis in the left fore-limb. At two months the therapeutic shoe was removed. The horse was “toe touching” with the injured (rig...

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Abstract

The present invention generally relates to methods for treating the sequela of laminitis in hoofed animals. Benefits are obtained by administering to the animals to be treated injections of Botulinum Toxin in the limb to be treated. In one embodiment, about 100 Units to 600 Units of Type A Botulinum Toxin is injected in multiple injections into the flexor digitorum profundus muscle of an animal's affected limb.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]Not ApplicableSTATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0002]Not ApplicableMICROFICHE APPENDIX[0003]Not ApplicableBACKGROUND OF THE INVENTION[0004]1. Field of the Invention[0005]This invention relates to laminitis in animals. More specifically, the invention comprises a method of treating the sequela of laminitis in animals, particularly horses.[0006]2. Description of the Related Art[0007]Laminitis is a serious medical condition in horses and other hoofed animals, and despite significant advances in veterinarian medicine, remains a major reason for euthanasia of such animals. Laminitis is an inflammation of the lamina (the lamellar attachment between the distal phalanx (coffin bone) and the inner hoof wall. Laminitis is characterized by separation of the hoof wall from the distal phalanx due to the deterioration and detachment of the lamina, which holds the two together. Failure of the laminar attachments, in a majo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/02A61P29/00
CPCA61K31/715A61P29/00
Inventor RENFROE, J. BENCARTER, DANIEL W.
Owner VETMED THERAPEUTICS INC
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