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USE OF POTASSIUM 2-(a- HYDROXYPENTYL) BENZOATE IN THE MANUFACTURE OF MEDICAMENTS FOR PREVENTING AND/OR TREATING SENILE DEMENTIA

a technology of potassium hydroxypentyl benzoate and manufacture of medicaments, which is applied in the direction of anhydride/acid/halide active ingredients, biocide, drug compositions, etc., can solve the problems of affecting the emerging of adverse effects, imposing a great burden on the family and society, and no effective drug for the treatment of aged dementia

Inactive Publication Date: 2011-09-15
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients of aged dementia suffer themselves, and also impose a great burden for their family and society.
There is no effective drug for treatment of aged dementia at present.
This kind of preparation could also influence the onset time or other properties such as compound level in the blood, thereby affecting the emerging of adverse effects.

Method used

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  • USE OF POTASSIUM 2-(a- HYDROXYPENTYL) BENZOATE IN THE MANUFACTURE OF MEDICAMENTS FOR PREVENTING AND/OR TREATING SENILE DEMENTIA
  • USE OF POTASSIUM 2-(a- HYDROXYPENTYL) BENZOATE IN THE MANUFACTURE OF MEDICAMENTS FOR PREVENTING AND/OR TREATING SENILE DEMENTIA
  • USE OF POTASSIUM 2-(a- HYDROXYPENTYL) BENZOATE IN THE MANUFACTURE OF MEDICAMENTS FOR PREVENTING AND/OR TREATING SENILE DEMENTIA

Examples

Experimental program
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Effect test

example 2

The Study of Aβ(25-35)-Induced Dementia in Rat: dl-PHPB Improves the Memory and Spatial Learning Abilities of Dementia Rats

1. Materials And Methods

[0139]dl-PHPB was offered by the department of medical synthetic chemistry of our institute. dl-PHPB was dissolved in PBS. Aβ(25-35) was purchased from SIGMA. The levels of SOD, ChAT, and MDA activities were determined with commercial colorimetric assay kits (Nanjing Jiancheng Bioengineering Institute, China). The content of protein in the supernatant was determined by Bradford method using BSA as the standard.

2. Instrument

[0140]The water maze apparatus was designed by Institute of Material Medica, Chinese Academy of Medical Sciences. Enzyme mark instrument (MQX 200) was purchased by Bio Tek Instruments. Paraffin section machine (IR2135) purchased by German Leica co., LTD. Thermostatic freezing section machine (620-E) purchased by UK Shandon co., LTD. Automatic microphotography system (Nikon ECLIPSE 80i) purchased by Japanese Nikon Corpor...

example 3

The Study in SAMP8 Mice: dl-PHPB Improves the Memory and Spatial Learning Abilities of SAMP8 Mice

1. Materials and Methods

[0155]dl-PHPB was offered by the department of medical synthetic chemistry of our institute. dl-PHPB was dissolved in PBS. The levels of MDA, SOD, ChAT and ATPase activities were determined with commercial colorimetric assay kits (Nanjing Jiancheng Bioengineering Institute, China). The content of protein in the supernatant was determined by Bradford method using BSA as standard.

2. Instrument

[0156]The water maze apparatus and DTT-2 jumping apparatus were designed by Institute of Material Medica, Chinese Academy of Medical Sciences. Enzyme mark instrument (MQX 200) was purchased from Bio Tek Instruments. Paraffin section machine (IR2135) purchased from German Leica co., LTD. Thermostatic freezing section machine (620-E) purchased from UK Shandon co., LTD. Automatic microphotography system (Nikon ECLIPSE 80i) purchased from Japanese Nikon Corporation.

3. Animals

[0157]...

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Abstract

The present invention discloses the use of potassium 2-(α-hydroxypentyl) benzoate in the manufacture of medicaments for preventing, relieving or treating senile dementia diseases or symptom, and for relieving oxidative stress injury in brain tissue, increasing neural function of choline, protecting neuron and / or raising the content of brain nerve growth factor. The present invention also discloses a pharmaceutical composition comprising potassium 2-(α-hydroxypentyl) benzoate in prophylactically or therapeutically effective dose, optionally, a pharmaceutically acceptable carrier and / or adjuvant.

Description

FIELD OF THE INVENTION[0001]The invention concerns prevention or treatment of neurological diseases, in particular of aged dementia. It relates to the use of dl-PHPB for the prevention or treatment of aged dementia, or a symptom thereof. The aged dementia includes Alzheimer's Disease, vascular dementia, and a combination of both. It also relates to pharmaceutical compositions for prevention or treatment of aged dementia, which contain dl-PHPB and pharmaceutically acceptable excipients or vectors. Pharmaceutical compositions of dl-PHPB for the manufacture are chosen from solution, suspension, emulsion, pill, capsule, powder, control or continuous release preparation. The invention also relates to methods for the prevention or treatment of aged dementia, including providing an effective dosage of dl-PHPB or pharmaceutical compositions containing dl-PHPB to patients. The approach of providing dl-PHPB to patients can include external al, oral, local, intracutaneously, intramuscular, per...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P25/28
CPCA61K31/192A61P25/28A61P43/00A61K9/08A61K9/107A61K9/20A61K9/48A61K9/14A61K9/0002
Inventor WANG, XIAOLIANGZHAO, WANHONGYANG, JINGHUAWANG, LINGLI, JIANGXU, SHAOFENGFENG, NANMA, SHIPING
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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