Photoprotector and/or photoimmunoprotector compositions of the skin and their uses

Abstract

The composition comprises of a component A selected from a hydroxylated derivative of benzoic acid or of cinamic acid, their esters, amides or salts, a glycoside of a hexose, and their mixtures; and a component B selected from quinic acid, shikimic acid, their alkaline metal or alkaline earth salts, their methyl esters, and mixtures of the same. This composition is suitable for protecting the skin against ultraviolet radiation coming from the sun or artificial sources, such as those used in phototherapy units and in sun tanning rooms. For application in the field of dermatology and nutrition, and, in particular, in the photoprotection of the skin and mucosa, photo-ageing and photocarcinogenesis, including protection of the immune system associated with the skin.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001]This application is a Continuation of U.S. patent application Ser. No. 11 / 541,350, filed Sep. 29, 2006, which is incorporated by reference herein.FIELD OF THE INVENTION[0002]In general, the invention is related to the field of dermatology and photobiology, and, in particular, to the area of photoprotection of the skin and mucosa, including the protection of the immune system associated with the skin. More specifically, the invention is related to a suitable composition to protect the skin against ultraviolet radiation coming from the sun or artificial sources, such as those used in phototherapy units and in sun tanning rooms.HISTORY OF THE INVENTION[0003]It is becoming increasingly evident that a large number of diseases of the skin are a result of the interaction of ultraviolet (UV) (290-400 nm) and visible (vis) (400-700 nm) radiation on the skin (Gonzalez E, Gonzalez S. Drug photosensitivity, idiopathic photodermatoses and sunscreens....

AI Technical Summary

Benefits of technology

[0008]The invention addresses the problem of providing an efficient composition to prevent or minimise the damaging effects produced by UV radiation on the skin.

[0009]The solution provided by the invention is based on the fact that inventors have observed that the combination of a series of components, in determined concentrations, produces a composition which demonstrates an antioxidant and photoprotector effect on the cutaneous cells both in vitro and in vivo, which helps to prevent or minimise the reactions which take place in the skin after a single or repeated exposure to UV radiation. Additionally, the aforementioned composition can be administered topically or orally without losing its photoprotector activity.

[0010]Therefore, in one aspect, the invention is associated with a photoprotector and / or photoimmunoprotector composition suitable for preventing or minimising the damaging effects produced by UV radiation on the skin. The aforementioned composition can be used in the preparation of pharmaceutical or cosmetic compositions, as well as food supplements used in the preparation of functional foods.

[0013]In another aspect, the invention is associated with the use of the aforementioned photoprotector and / or photoimmunoprotector composition in the preparation of a drug or pharmaceutical composition to prevent or minimise the damaging effects produced by UV radiation on the skin.

Problems solved by technology

In fact, numerous scientific studies suggest that the uncontrolled exposure to solar radiation and ultraviolet radiation coming from artificial lamps is harmful to the human skin and produce burns, damage to the epidermal and dermal cells, induction of cell death, changes in pigmentation, immunosuppression, premature ageing, and, eventually, skin cancer (Young A R. Chronic effects of ultraviolet radiation on the skin.

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