46 results about "Photo ageing" patented technology

The invention relates to a composition for topical application or oral administration, containing an effective quantity of at least one inhibitor of the enzyme 3beta-hydroxysteroid dehydrogenase. This composition is designed in particular for the treatment of certain effects of chronological ageing and photo-ageing of the skin.

Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.

The objective of the invention is to provide a photo-aging prophylactic agent for skin with novel ingredients and foods using the photo-aging prophylactic agent for skin, medicaments for mammals including human beings and a skin external agent, as well as feed for mammals. The inventive photo-aging prophylactic agent for skin is characterized by taking extracts of Orobanchaceae plants as effective ingredients. The photo-aging prophylactic agent for skin preferably comprises phenylethanoid glycosides compounds as effective ingredients. Moreover, the photo-aging prophylactic agent for skin preferably comprises at least one of echinacoside and acteoside as the phenylethanoid glycosides compounds. On top of that, the photo-aging prophylactic agent for skin preferably comprises both echinacoside and acteoside as the phenylethanoid glycosides compounds. In addition, the photo-aging prophylactic agent for skin can be employed as medicaments for mammals including human beings, skin external agents, consumptive foods and feed for mammals.

The invention herein encompasses methods effective to stimulate epithelial cell proliferation and / or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of beta -glucosidase activity or beta -glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions. The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of beta -glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.

The invention discloses a weather resistance powder coating, comprising the following components: 35%-45% of hydroxylated acrylic resin with a hydroxyl value of 35-45mg / a, 30%-35% of terminal carboxy polyester resin with a acid value of 60-70mg KOH / g, 3%-5% of tetramethoxy methyl glycoluril, 0.5%-1.3% of acrylic type flatting agent, 20%-30% of barium sulfate, and 0.5%-1.5% of benzoin. The weather resistance of the powder coating of the invention is greatly improved, 480h QUV-B(accelerated photo-ageing test) gloss retention of the powder coating is increased from 50% which is the gloss retention of the traditional polyester powder coating to 95% so that the outdoor high weather resistance coating requirements can be satisfied; the cost of the invention is lower than that of fluorocarbon resin powder coating and organosilicon resin powder coating (the cost can be reduced by about 50%).

The composition comprises of a component A selected from a hydroxylated derivative of benzoic acid or of cinamic acid, their esters, amides or salts, a glycoside of a hexose, and their mixtures; and a component B selected from quinic acid, shikimic acid, their alkaline metal or alkaline earth salts, their methyl esters, and mixtures of the same. This composition is suitable for protecting the skin against ultraviolet radiation coming from the sun or artificial sources, such as those used in phototherapy units and in sun tanning rooms. For application in the field of dermatology and nutrition, and, in particular, in the photoprotection of the skin and mucosa, photo-ageing and photocarcinogenesis, including protection of the immune system associated with the skin.

The present invention relates to sirtuin 6 activating peptides, derived from highly conserved regions of human SIRT proteins, and to a cosmetic or pharmaceutical composition comprising at least one sirtuin 6 activating peptide in a physiologically acceptable medium. The invention further relates to the utilization of a cosmetic composition to prevent and / or repair DNA degradation, improve telomere maintenance and reduce cellular senescence. The invention also applies to a cosmetic treatment process intended to prevent and / or treat the cutaneous signs of aging and photo aging.

The invention belongs to the field of organic functional molecule modified hydrotalcite and particularly relates to hydrotalcite of which the surface is grafted with an organophosphorus heterocyclic compound, and a preparation method of hydrotalcite. According to the method disclosed by the invention, a silane coupling agent serves as a bridging linker in supercritical carbon dioxide, and the organophosphorus heterocyclic compound is chemically grafted to the surface of hydrotalcite, wherein the silane coupling agent accounts for 0.1-50 wt% of the total weight of hydrotalcite of which the surface is grafted with organic functional molecules, the organophosphorus heterocyclic compound accounts for 0.1-50 wt%, and the balance is hydrotalcite. The hydrotalcite of which the surface is grafted with the organic functional molecules, disclosed by the invention, can serve as a functional assistant, is added into macromolecular materials, such as polyolefins, polyesters, epoxy resin, binders, coating materials, rubber or fibers, and is used for improving the thermal ageing resistance, photo-aging resistance, heat resistance, transparency, flame retardance and the like of the prepared materials.

A cosmetic composition is provided comprising a Gingko biloba extract, an alkyl β,β-diphenylacrylate and / or α-cyano β,β-diphenylacrylate derivative, and a dibenzoyl methane derivative. A cosmetic use of that composition is also provided for preventing sun damage and photo ageing.

Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.

Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.

The invention provides the use of silica for cosmetic and / or medical treatment of skin, including improving and enhancing the skin-barrier, anti-aging treatment and photo-protective treatment. The invention is based on the finding that silica exhibits a multi-faceted biological effect useful in the cosmetic and / or therapeutic treatment of skin for the above purposes. Specifically, it has been shown that silica induces markers (involucrin, filaggrin and transglutaminase-1) for skin barrier formation in keratinocytes, induces collagen expression in dermal fibroblasts and inhibits UVA-induced up-regulation of photo-aging markers (matrix metalloproteinase MMP-1 and cytokine IL-6).

A cosmetic composition is provided comprising a Gingko biloba extract, an alkyl beta,beta-diphenylacrylate and / or alpha-cyano beta,beta-diphenylacrylate derivative, and a dibenzoyl methane derivative. A cosmetic use of that composition is also provided for preventing sun damage and photo ageing.

The present invention relates to a composition for the skin whitening and wrinkle improvement, comprising an extract of Vaccinium uliginosum as an active ingredient. The Vaccinium uliginosum extract has the effects of inhibiting and scavenging reactive oxygen species produced in skin tissue as a result of ultraviolet irradiation to the skin, effectively inhibiting tyrosinase activity to inhibit the production of melanin in melanin cells, inhibiting the secretion of cytokines in keratinocytes, promoting the production of procollagen, and inhibiting the decomposition of collagen. Thus, the extract will be useful for the prevention of skin photo aging caused by ultraviolet radiation, the enhancement of skin whitening and the improvement of wrinkles. In addition, the Vaccinium uliginosum extract is suitable to use as a component for improving skin wrinkles in cosmetics, foods and drugs, because the Vaccinium uliginosum extract can achieve the effect of improving skin conditions, even when it is applied to the skin or used internally.

The invention provides the use of extracts from algae for cosmetic and / or medical treatment of skin, including improving and enhancing the skin-barrier, anti-aging treatment and photo-protective treatment. The invention is based on the finding that extracts from algae obtainable from saline hot water sources exhibit a multi-faceted biological effect useful in the cosmetic and / or therapeutic treatment of skin for the above purposes. Specifically, it has been shown that such algae extracts induce markers (involucrin, filaggrin and transglutaminase-1) for skin barrier formation in keratinocytes, induce collagen expression in dermal fibroblasts and inhibit UVA-induced up-regulation of photo-aging markers (matrix metalloproteinase MMP-1 and cytokine IL-6).

The invention belongs to the technical field of cosmetics and relates to a chlorophyll-containing skincare product capable of resisting sunburn and repairing after sunburning. The chlorophyll-containing skincare product capable of resisting sunburn and repairing after sunburning is prepared from chlorophyll compound liposome, hydrogenated jojoba oil, amygdalus pedunculata oil, squalane, cyclopentasiloxane, cetostearyl alcohol, PEG-100 stearate, tocopheryl acetate, bisabolol, butanediol, beta-glucan, sodium hyaluronate, carbopol, mycose, cetearyl glucoside, vitamin C ethyl ether, moringa oleifera leaf extract, triethanolamine, preservatives, essence and water. The chlorophyll-containing skincare product is stable in property, high in safety and high in usage comfort, is capable of effectively resisting ultraviolet rays of different wavebands, also has a good function of resisting photo-aging, and is also capable of preventing symptoms such as skin aging, freckles and desquamation and the like caused by sunburn and accelerating the repairing of the skin after sunburning.

The invention discloses a Chinese herbal medicine extract, and is characterized in that, the Chinese herbal medicine extract is an extract of water containing 10-50 parts by weight of snow lotus, 10-50 parts by weight of cistanche, and 20-60 parts by weight of astragalus mongholicus and / or solvent, wherein the solvent is selected from methanol, ethanol, isopropanol, n-butyl alcohol, ethylene glycol, 1,2-propylene glycol, 1,3-propylene glycol, 1,3-butylene glycol, acetone, ethyl acetate or the combinations thereof. The extract and the Chinese herbal medicine composition containing the extract can be directly used for preventing skin ageing, especially photo-ageing, and can also be added in cosmetic as a functional additive. The Chinese herbal medicine extract and the Chinese herbal medicine composition disclosed by the invention have an anti-ageing function, especially an anti-photo-ageing function, help skin to be antioxidant and promote the proliferation of dermal fibroblast, especially help skin to resist the ultraviolet irradiation of UVB (ultraviolet B) and UVA (ultraviolet A), and have the advantages of protecting skin, reducing injury and preventing skin from photo-ageing, and having no irritation on skin.

The present invention relates to sirtuin 6 activating peptides derived from highly conserved regions of human Sirtuin (SIRT) proteins, and to a cosmetic or pharmaceutical composition comprising at least one sirtuin 6 activating peptide in a physiologically acceptable medium. The invention further relates to the utilization of a cosmetic composition to prevent and / or repair Deoxyribonucleic acid (DNA) degradation, improve telomere maintenance and reduce cellular senescence. The invention also applies to a cosmetic treatment process intended to prevent and / or treat the cutaneous signs of aging and photo aging.

Therapeutic compositions and methods for using same for treating skin conditions and diseases are disclosed. Treatable skin conditions and diseases include without limitation acne vulgaris, rosacea, seborrheic dermatitis, eczema (atopic dermatitis), psoriasis, photo-aging and actinic keratosisacne vulgaris, psoriasis, photo-aging and eczema. Therapeutic compositions disclosed are derived from Porifera species, specifically sponges, and more specifically fresh water sponges. One disclosed embodiment is derived from Spongilla species and is formulated with pharmaceutically acceptable excipients.

The invention provides a preparation method of a polypeptide for inhibiting activity of matrix metalloproteinase in photo-aged skin; by taking fish skin as a raw material, an enzyme sensor-artificial neural network online monitoring model is established through a combined enzyme of alkaline protease and pancreatin to control a hydrolysis progress, so that hydrolysis degree is 18%-19%; an enzymatic hydrolysis solution is filtered by virtue of a microporous filtering membrane of 0.22 micron and active peptide with molecular weight cutoff ranging from 300Da to 1000Da is ultra-filtered by virtue of a spiral-wound ultrafiltration membrane; and finally, the peptide is subject to sequential separation and purification by virtue of an SP-Sephadex C25 cation exchange column and a Sephadex G25 gel column, and the peptide is freeze-dried so as to obtain a target antagonist peptide that a main feature segment is Gly-Pro matrix metalloproteinase (MMPs). The fish skin gelatin derived bioactive peptide prepared by the invention is capable of significantly inhibiting the increase in skin MMPs content caused by ultraviolet ray and is relatively good in anti-oxidative activity; and the antagonist peptide provides a wider prospect for the development and utilization of active peptide which is prepared from fish skin gelatin and has photo-aging resisting activity for skin.

Therapeutic compositions and methods for using same for treating skin conditions and diseases are disclosed. Treatable skin conditions and diseases include, for example, acne vulgaris, rosacea, seborrheic dermatitis, eczema (atopic dermatitis), psoriasis, photo-aging and actinic keratosisacne vulgaris, psoriasis, photo-aging and eczema. Therapeutic compositions disclosed are derived from Porifera species, specifically sponges, and more specifically fresh water sponges. One disclosed embodiment is derived from Spongilla species and is formulated with pharmaceutically acceptable excipients.

The invention provides a thermoplastic elastomer composite processing method of color door frame type sealing strips, comprising the following steps of: (1) material feeding; (2) extrusion of rubber sealing strips through an extruder; (3) microwave vulcanization; (4) hot air vulcanization; (5) arrangement of the vulcanized rubber sealing strips into the extruder, and extrusion of thermoplastic elastomers to cover density rubber; (6) water tank cooling; and (7) material discharge, wherein the cooled section bars are cut with the desired length and then are orderly arranged in a circulating box. The invention separates a thermoplastic elastomer composite working operation and mutually divides two processing techniques of rubber and thermoplastic elastomers. In the invention, the extruded thermoplastic elastomers are cooled only, and the performance of the thermoplastic elastomers depends on the material per se and is not influenced by other working operations, thereby improving the quality of the products and controlling the production cost. The color thermoplastic elastomers are composite and have smooth and clear surfaces, thus the photo-aging and thermal-aging performances are not influenced by heating any more.

The invention relates to an anti-aging master batch and belongs to the field of chemical engineering formulas. The anti-aging master batch is composed of following raw materials, by weight, 20-30 parts of polyethylene, 20-40 parts of polypropylene, 20-30 parts of a photo-stabilizer, 5-20 parts of a filler, 1-2 parts of a dispersing agent and 2-4 parts of a coupling agent. The anti-aging master batch is greatly improved in use performance, has excellent social and economical benefit, is suitable for polypropylene flexible freight bags or woven bags having anti-aging requirement, can effectively inhibit thermo-degradation of polypropylene in processing, and delaying thermo-oxidative aging and photo-aging during use.

A method for anti-skin aging, especially for anti-skin photo-aging in a subject is provided. The method comprising administering to the subject an effective amount of an active component selected from the group consisting of a caffeamide derivative of formula (I), a pharmaceutically acceptable salt of the caffeamide derivative, and a combination thereof:wherein A is H or an alkyl; B is —[CH2]m—; m is an integer ranging from 0 to 10; R1 is H, an optionally substituted phenyl, an optionally substituted pyridyl, —OH, or —OCH3; or, N, A, B, and R1 together form an optionally substituted pyrrolyl or piperidyl.

The invention provides a large-size LED (light emitting diode) panel lamp with a novel light guide plate, relates to the field of LED lighting and belongs to the LED panel lamp using a plurality of groups of flat glass and polymer thin films as the light guide plate through superposition. A plurality of groups of flat glass and polymer thin films are used as the light guide plate through superposition, wherein the flat glass adopts glass materials with high refractive index, the nd value is greater than 1.6, and the polymer thin films adopt transparent materials with lower refractive index, so each layer of glass becomes a light guide layer, and in addition, the light guide distance is longer. The large-size LED panel lamp has the characteristics that the structure is simple, the mechanical intensity is high, the deformation cannot easily occur, the photo-ageing resistance is realized, and the absorption rate on UV (ultravioletb) light is high.

A high molecular material ultraviolet radiation aging device. The invention relates to the high molecular material ultraviolet radiation aging device which solves problems of poor utilization efficiency of a light source in a photo-aging device and complex structure of the device in the prior art. The aging device is composed of a fluorescent ultraviolet light tube, a light head, a coating barrel and two light tube supporting parts. The coating barrel is formed by hinging a left semi-cylinder and a right semi-cylinder to each other. The light tube supporting parts are respectively buckled onto the two opening ends of the coating barrel. A supporting bracket is arranged on internal circumference surfaces of the light tube supporting parts. The supporting bracket is attached to the fluorescent ultraviolet light tube. The light head is fixed to the supporting parts. A plurality of radiation degree observing holes are formed in the coating barrel. The ultraviolet radiation aging device requires fewer assemblies and is simple in structure. By means of a barrel column structure of the coating barrel, almost light emitted by the light tube can be absorbed by a tested material so that a light source utilization rate is high.

The invention discloses an anti-aging and anti-tension plastic and a preparation method thereof. The plastic comprises the following components in parts by weight: 52-67 parts of rubber, 21-28 parts of hydroxymethyl aliphatic amine, 16-34 parts of amyl acetate, 10-20 parts of tridecyl, 10-20 parts of zinc oxide and 20-30 parts of coupling agent. The preparation method of the anti-aging and anti-tension plastic is characterized by firstly putting the rubber, hydroxymethyl aliphatic amine and the coupling agent in a reaction vessel, stirring the materials to react the materials at 50 DEG C, heating after reacting for 60 minutes, gradually adding amyl acetate, tridecyl and zinc oxide, stirring the materials to react the materials, simultaneously heating to 120 DEG C to react the materials for 2 hours, and sending the reactant to an injection molding machine to undergo injection molding. The plastic has a reasonable formula. The preparation method is simple. The prepared plastic is anti-aging and anti-tension. Experiments prove that the tensile strength of the plastic is 27-30MPa and the 500h photo-aging impact strength retention rate is 100%.