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Medical fluid, a method of treatment and use of the fluid

a technology of medical fluid and fluid, applied in the field of medical fluid, can solve the problems of inability to immediately transplant organs, inability to cure disease, and inability to cure disease, and achieve the effect of alleviating, eliminating or reducing one or more of the above-identified deficiencies and disadvantages

Inactive Publication Date: 2013-03-14
XVIVO PERFUSION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The aim of this patent is to resolve one or more issues and disadvantages. The technical effects of this invention are to lessen, reduce, or eradicate particular issues that previously existed.

Problems solved by technology

It is well known that there is a great shortage of donor organs, which may be used for transplantation.
Normally, the organs cannot be transplanted immediately, but a recipient should be found, which may take some time.
Such medical fluids involve compromises between cost and performance.

Method used

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  • Medical fluid, a method of treatment and use of the fluid

Examples

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Embodiment Construction

[0015]Below, several embodiments of the invention will be described. These embodiments are described in illustrating purpose in order to enable a skilled person to carry out the invention and to disclose the best mode. However, such embodiments do not limit the scope of the invention. Moreover, certain combinations of features are shown and discussed. However, other combinations of the different features are possible within the scope of the invention.

DEFINITIONS

[0016]In the context of the present description and embodiments the following definitions apply: The term “cocaine analogue” is intended to mean an analogue, which acts in the same or a similar way as cocaine in preserving organs after harvesting of the organs. The term “Pharmaceutically acceptable” means a non-toxic material that does not decrease the effectiveness of the biological activity of the active ingredients. The term “physiologically acceptable solution” means a solution that does not interfere substantially with t...

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Abstract

A medical fluid for a harvested organ, tissue or parts thereof, for evaluation and / or preservation. The fluid includes cocaine or a stimulating analogue thereof; nor-adrenalin; and / or adrenaline. In addition, the fluid includes an oncotic agent, such as dextran; hormones, such as thyroxin; triiodotyronine; cortisone, insulin; and electrolytes and optionally nutrients in substantially physiological concentrations in a physiologically acceptable medium. In addition, the medical fluid further includes albumin in a concentration not exceeding 5.0%, and an oxygen carrier, such as erythrocytes. Further components may be dopamine; hydrocortisone; methylprednisolone; and a vasopressor agent, such as desmopressin. The cocaine; adrenalin; and noradrenaline are present in concentrations of each about 0.010 μM to 0.100 μM, for example in a ratio of 1:1:1.

Description

FIELD OF INVENTION[0001]The present invention relates to a method of handling an organ after harvesting, including a medical fluid and use of said fluid.BACKGROUND OF THE INVENTION[0002]It is well known that there is a great shortage of donor organs, which may be used for transplantation.[0003]After harvesting, the organs should be examined and evaluated for viability to be used for transplantation purpose. The evaluation may be performed at a physiological temperature of about 37° C., such as between 30° C. and 40° C., or alternatively at a lower temperature. During the evaluation, the organs may be perfused by and / or surrounded by an evaluation fluid similar to blood.[0004]Normally, the organs cannot be transplanted immediately, but a recipient should be found, which may take some time. Moreover, the organ to be transplanted should be transported to the recipient or the recipient be transported to the organ. Thus, the organs may be preserved for some hours or days, often at hypoth...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A01N1/02
CPCA01N1/0226
Inventor STEEN, STIG
Owner XVIVO PERFUSION
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