Use of a dpp-4 inhibitor in sirs and/or sepsis

a dpp4 inhibitor and sepsis technology, applied in the field of dpp4 inhibitors, can solve the problems of microcirculatory dysfunction, abnormal coagulation and blood flow, excessive inflammation or immunosuppression, etc., and achieve the effect of reducing the risk

Inactive Publication Date: 2013-11-14
BOEHRINGER INGELHEIM INT GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0024]Further, the present invention relates a certain DPP-4 inhibitor (preferably linagliptin, optionally in combination with one or more other active agents) for use in treating, preventing and / or and / or reducing the risk of SIRS / sepsis, which is one or more selected from septic or non-septic SIRS, severe SIRS / sepsis, SIRS / septic shock and multi-organ failure associated with SIRS / sepsis.
[0026]Further, the present invention relates to a method of treating, preventing and / or reducing the likelihood or risk of systemic inflammatory response syndrome (SIRS) and / or sepsis (SIRS / sepsis) in a patient (particularly human patient) in need thereof, comprising administering an effective amount of a certain DPP-4 inhibitor (preferably linagliptin), optionally in combination with one or more other active agents, to the patient.

Problems solved by technology

The nature of the interactions between the microbial pathogen and the host is complex and, at the tissues, results in excessive inflammation or immunosuppression, abnormal coagulation and blood flow, and microcirculatory dysfunction leading to organ injury and cell death.
On the other hand, patients suffering from sepsis in a later status consistently show a decline in their immune responsiveness (immune deficiency of the adaptive immune system).

Method used

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  • Use of a dpp-4 inhibitor in sirs and/or sepsis
  • Use of a dpp-4 inhibitor in sirs and/or sepsis
  • Use of a dpp-4 inhibitor in sirs and/or sepsis

Examples

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examples

Survival of Septic Rats with and without Linagliptin Treatment

[0281]Female Wistar rats are fed a diet containing 0.083 mg / kg linagliptin (corresponding to 50-150 nM mean plasma concentration) for 6 day or control diet. Animals are injected at day 2 with 10 mg / kg LPS (lipopolysaccharide) i.p. and observed for 4 additional days.

[0282]Three groups of female Wistar rats are compared with respect to proportion surviving 24 hours LPS (lipopolysaccharide, 10 mg / kg i.p.) treatment using Fisher's exact test for 2 by 3 tables (p=0.004), and additionally, group b and c are compared using Fisher's two-sided exact test for 2 by 2 tables (p=0.015, LPS vs. LPS+Linagliptin). It should be noted that the survival curve only represents preliminary data (“pseudo Kaplan-Meier-curve”) since the exact time point of death of the rats is not assessed. The female Wistar rats are injected with LPS in the morning, monitored during the day and transferred back to the stable in the evening. Deaths are registered...

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Abstract

The present invention relates to methods for treating and / or preventing SIRS and / or sepsis comprising the administration of an effective amount of a certain DPP-4 inhibitor, as well as to the use of a certain DPP-4 inhibitor for treating and / or preventing a metabolic disease in a patient with or at risk of SIRS and / or sepsis.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a certain DPP-4 inhibitor (preferably linagliptin, optionally in combination with one or more other active agents) for use in treating, preventing and / or reducing the risk or likelihood of systemic inflammatory response syndrome (SIRS) and / or sepsis (SIRS / sepsis) and / or diseases related or associated therewith, to pharmaceutical compositions and combinations comprising such active components, and to certain therapeutic uses thereof.[0002]Further, the present invention relates a certain DPP-4 inhibitor (preferably linagliptin, optionally in combination with one or more other active agents) for use in treating, preventing and / or and / or reducing the risk of SIRS / sepsis, which is one or more selected from septic or non-septic SIRS, severe SIRS / sepsis, SIRS / septic shock and multi-organ failure associated with SIRS / sepsis.[0003]Further, the present invention relates a certain DPP-4 inhibitor (preferably linagliptin, optionally i...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D473/06A61K45/06A61K31/522
CPCC07D473/06A61K31/522A61K45/06A61K31/4985A61K31/5025A61K31/519A61P1/16A61P13/02A61P13/12A61P15/00A61P19/10A61P25/00A61P25/28A61P27/02A61P29/00A61P3/00A61P3/04A61P31/00A61P31/04A61P3/06A61P43/00A61P9/00A61P9/10A61P9/12A61P3/10A61K2300/00
Inventor KLEIN, THOMASDAIBER, ANDREASDUGI, KLAUSMARK, MICHAELMUENZEL, THOMAS
Owner BOEHRINGER INGELHEIM INT GMBH
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