CoQ10 (Ubiquinone, Ubiquinol), Vitamin A (Retinoid Acid, Retinol), Vitamin E (Tocotrienol, Tocopherol) and Methods of Use

Inactive Publication Date: 2015-01-08
TAN BARRIE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes the use of vitamin E (tocopherol and tocotrienol) to reduce the levels of ubiquinone to ubiquinol in a person's body, and to protect ubiquinol from oxidation. It also mentions that tocopherol can be combined with ubiquinol to stabilize it and prevent its loss in the body. Additionally, the patent describes how vitamin E can protect the oxidation of retinol to retinoic acid in the body, and reduce retinoic acid to retinol.

Problems solved by technology

However, with age, oxidative stress and chronic inflammation, the body's ability to convert ubiquinone to ubiquinol is compromised (FIG. 1A).
The physiological role of retinoic acid in the body remains controversial or, at best, is uncertain.
It is therefore understood that the oxidized form of vitamin A, retinoic acid, is detrimental.

Method used

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  • CoQ10 (Ubiquinone, Ubiquinol), Vitamin A (Retinoid Acid, Retinol), Vitamin E (Tocotrienol, Tocopherol) and Methods of Use
  • CoQ10 (Ubiquinone, Ubiquinol), Vitamin A (Retinoid Acid, Retinol), Vitamin E (Tocotrienol, Tocopherol) and Methods of Use
  • CoQ10 (Ubiquinone, Ubiquinol), Vitamin A (Retinoid Acid, Retinol), Vitamin E (Tocotrienol, Tocopherol) and Methods of Use

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0088]CoQ10 encapsulated supplements with various mixtures of vitamin E (tocopherol-free tocotrienols, tocopherol-tocotrienol mixtures, tocotrienol-free tocopherols, esterified vitamin E) were analyzed for ubiquinol and ubiquinone simultaneously by high performance liquid chromatography (HPLC) using a modified method of an existing collaborative study (Lunetta and Roman, 2008). Samples were prepped by expelling contents from softgels / capsules and transferring them quantitatively to a volumetric flask. Softgels were then rinsed exhaustively using ethanol, and rinses were transferred to the flasks. Sonication was used as needed to completely clean out the gels. Samples were standardized to volume with ethanol, then the flasks were stoppered and mixed thoroughly. Samples were diluted and immediately injected (20 uL injection volume) onto an HPLC manufactured by Thermo Separation Products with in-line degasser, P4000 pump, AS3000 Autosamples, and scanning detector. The column used was a...

example 2

[0100]Conditions were set as in Example 1. All encapsulated supplements with esterified vitamin E (e.g., alpha-tocopheryl acetate, alpha-tocopheryl succinate) saw zero conversion of ubiquinone to ubiquinol. Only vitamin E alcohols are effective.

example 3

[0101]Conditions were set as in Example 1. Encapsulated supplements without tocopherol and / or tocotrienol saw zero conversion of ubiquinone to ubiquinol, as shown in FIG. 4. Furthermore, the amount of CoQ10 was diminished by 20% of the labeled value. Vitamin E protects from degradation of CoQ10, and without added vitamin E no ubiquinol was detected.

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Abstract

CoQ10 and vitamin E are both lipid-soluble nutrients with redox potential. Tocopherol and / or tocotrienol protect CoQ10 from oxidative damage and reduce ubiquinone in situ. Specifically, vitamin E protects the oxidation of ubiquinol to ubiquinone ex vivo and reduces ubiquinone to ubiquinol in situ. Vitamin Es with higher ratio of tocotrienol-to-tocopherol cause a higher ratio of ubiquinol-to-ubiquinone. Additionally tocopherol and / or tocotrienol protect vitamin A oxidation from retinol to retinoic acid.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority upon U.S. Provisional Patent application Ser. No. 61 / 842,732 filed on Jul. 3, 2013, the contents of which are all herein incorporated by this reference in their entireties. All publications, patents, patent applications, databases and other references cited in this application, all related applications referenced herein, and all references cited therein, are incorporated by reference in their entirety as if restated here in full and as if each individual publication, patent, patent application, database or other reference were specifically and individually indicated to be incorporated by reference.BACKGROUND OF THE INVENTION[0002]Co-enzyme Q10 (CoQ10) is a co-enzyme; a substance in the body that assists the function of an enzyme or enzyme system. CoQ10 was discovered in 1957, and its molecular structure was determined in 1958 to be 2,3-dimethoxy-5-methyl-6-decaprenil-1,4-benzoquinone. Its biological presen...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K47/22A61K31/09
CPCA61K31/122A61K47/22A61K31/09A61K9/06A61K31/05A61K31/07A61K31/352A61K31/353A61K31/355A61K31/593A61K47/24
InventorTAN, BARRIE
OwnerTAN BARRIE