Injectable combination of adrenergic receptor agonists with fillers, for decreasing skin reactions due to injection
a technology of adrenergic receptor and filler, which is applied in the field of injectable combination of adrenergic receptor agonists and fillers, can solve problems such as dissuasion of some patients, and achieve the effects of reducing oedema and swelling, and hindering liquid concentration
a technology of adrenergic receptor and filler, which is applied in the field of injectable combination of adrenergic receptor agonists and fillers, can solve problems such as dissuasion of some patients, and achieve the effects of reducing oedema and swelling, and hindering liquid concentration
US20150320743A1Inactive Publication Date: 2015-11-12GALDERMA RES & DEV SNC
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LEGENDS TO FIGURES
[0070]FIG. 1 shows the Irritating Primary Index (IPI) evolution between Day 0 and Day 8 for the claimed composition (Test2) in comparison with a filler alone (Test1).
[0071]FIG. 2 shows the total score of inflammatory reaction at Day 8 for the claimed composition (Test2) in comparison with a filler alone (Test1).
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The present invention concerns an injectable composition comprising a filler or a botulinum toxin and an adrenergic receptor agonist, and its use for diminishing, decreasing or avoiding skin reactions due to injection, specially redness, ecchymosis, bruising, bleeding, erythema, oedema, necrosis, ulceration, swelling and / or inflammation.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of co-pending U.S. patent application Ser. No. 13 / 322,803 filed Feb. 7, 2012, which is a national stage application under 35 U.S.C. §371 of PCT Application No. PCT / EP2010 / 057493, filed May 28, 2010, which claims priority to and the benefit of U.S. provisional patent application Ser. No. 61 / 213,322, filed May 29, 2009, each of which is incorporated herein by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention is in the surgical and dermatological domain.[0003]The present invention relates to an injectable composition comprising an adrenergic receptor agonist, preferably brimonidine, and a filler, preferably hyaluronic acid. It concerns its use in preventing and / or treating superficial bruising and bleeding caused by aesthetic procedures.BACKGROUND OF THE INVENTION[0004]Superficial bruising and, to a lesser extent, bleeding are not uncommon consequences—reported on average about one...
Claims
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Patent Timeline
12 Nov 2015
Publication
US20150320743A1
- IPC
- A61K31/498; A61K31/167; A61K38/16; A61L27/20; A61L27/54
- CPC
- A61K31/498; A61L27/20; A61L27/54; A61K38/164; A61L2300/40; A61L2400/06; A61L2300/402; A61L2300/204
- Inventors
- BERTHOLON, ISABELLE; BRUNEL, FLORENCE