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Artificial blood vessel

A technology of artificial blood vessels and blood, which is applied in the direction of blood vessels, human tubular structure devices, anticoagulant treatment, etc., and can solve the problems of promoting thrombus formation

Active Publication Date: 2016-09-28
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is a problem that platelets adhere to gels such as gelatin absorbed in the living body, which instead promotes the formation of thrombus.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0249] As the warps and wefts constituting the inner tubular fabric, polyethylene terephthalate multifilament yarns having a single yarn fineness of 0.23 dtex, a total fineness of 33 dtex, and 144 filaments were used. In addition, as the warp yarns constituting the outer layer tubular fabric, a polyethylene terephthalate multifilament yarn with a single yarn fineness of 2.33 dtex, a total fineness of 56 dtex, and 24 filaments was used. For the weft yarn, polyethylene terephthalate monofilament yarn with a single yarn denier of 33 dtex was used. The warp was set on a dobby / double-shuttle loom (slim ドビー・シャトル 2-Ding loom), and the weft was woven so that the inner diameter became 3 mm. The scouring was performed at 98° C., and the heat setting was performed at 170° C. to obtain a multiple tubular fabric structure 1 .

[0250] Then, the tubular fabric 1 was immersed in an aqueous solution of 5.0 wt % potassium permanganate (manufactured by Wako Pure Chemical Industries, Ltd.) and ...

Embodiment 2

[0256] As the weft yarns constituting the inner tubular fabric, untwisted sea-island composite fibers with a single yarn fineness of 7.3 dtex and a total fineness of 66 dtex (sea / island (weight ratio) = 20 / 80 composite ratio, and island fraction of 70) were used. ) multifilament yarn, after refining, the sea component was completely dissolved in an aqueous solution of 4 wt% sodium hydroxide (manufactured by Wako Pure Chemical Industries, Ltd.) at 98°C, and further heat-setting was performed to form a single yarn fineness of 0.084 dtex, Except for the polyethylene terephthalate multifilament yarn having a total fineness of 53 dtex and 630 filaments, the same operation as in Example 1 was performed, and a multi-tubular fabric structure 2 was obtained.

[0257] Here, in the sea-island composite fiber, the island component polymer is composed of polyethylene terephthalate multifilament yarn, and the sea component polymer is composed of polyethylene terephthalate copolymerized with ...

Embodiment 3

[0261] As the warp and weft constituting the inner layer tubular fabric, the multifilament yarn as the sea-island composite fiber used in Example 2 was used, and after refining, 4 wt % sodium hydroxide (manufactured by Wako Pure Chemical Industries, Ltd. ) in the aqueous solution of ) to completely dissolve the sea component, and further heat-setting was performed to form a polyethylene terephthalate multifilament yarn with a single yarn fineness of 0.084 dtex, a total fineness of 53 dtex, and 630 filaments. The same operation as in Example 1 was carried out, and the multi-tubular fabric structure 3 was obtained by weaving.

[0262] The same operation as in Example 1 was performed on the obtained multiple tubular fabric structure 3 to obtain an artificial blood vessel (sample 3) in which the antithrombotic material layer was formed.

[0263] About the obtained artificial blood vessel (Sample 3), blood leakage evaluation, antithrombotic evaluation and cell affinity evaluation w...

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Abstract

Provided is an artificial blood vessel comprising a cylindrical 3D woven textile structure with minimal blood leakage and which combines antithrombotic properties and cellular affinity. This artificial blood cell is a cylindrical textile structure having positioned therein a cylindrical textile, the inner surface of which comes into contact with blood, the cylindrical textile being a textile obtained by interweaving a plurality of warp yarns and a plurality of weft yarns, the warp yarns and weft yarns that constitute the cylindrical textile containing a multi-filament yarn having a single filament fineness not exceeding 0.50dtex, bonded with an antithrombotic material, the antithrombotic material forming an antithrombotic material layer having a thickness of 1-600nm on the inside of the cylindrical textile, and the water permeability when the inner surface is subjected to a pressure of 16kPa being less than 300mL / cm2 / min.

Description

technical field [0001] The present invention relates to a fabric artificial blood vessel with less blood leakage and both antithrombotic properties and cell affinity. Background technique [0002] An artificial blood vessel is a medical device used to replace a diseased living blood vessel such as arteriosclerosis, or to form a branch or a bypass. The conventional artificial blood vessels can be roughly classified into 1) cloth, 2) polytetrafluoroethylene, 3) living material, and 4) synthetic polymer material. Among these artificial blood vessels, cloth artificial blood vessels made of woven fabrics, knitted fabrics, or non-woven fabrics of fibers have high flexibility, but under actual use conditions, blood pressure is applied, so there is a disadvantage that blood is easily leaked from the interfiber space. . Among the cloth artificial blood vessels, the artificial blood vessel composed of knitted fabrics has simple manufacturing steps and flexibility, but has poor shape...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06A61L27/00
CPCD03D3/02D10B2509/06A61L27/507A61L33/0076A61F2/06A61F2210/0076A61F2230/0069D03D15/33A61L27/18A61L33/068A61L2300/42A61L27/50A61L33/06B82B1/00
Inventor 藤田雅规门胁功治阪口有佳棚桥一裕土仓弘至山田谕
Owner TORAY IND INC
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