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Extracorporeal blood treatment apparatus

a technology of extracorporeal blood and apparatus, which is applied in the direction of haemofiltration, suction devices, other medical devices, etc., can solve the problems of unsatisfactory sodium loading in the patient and discomfort of the subject, and achieve the effect of convenient us

Active Publication Date: 2018-05-24
GAMBRO LUNDIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention aims to provide an extracorporeal blood treatment apparatus that can automatically determine the proper dialysis fluid content for a substance present in the blood, particularly an ionic substance. Additionally, the invention provides a selectable biosensing-based therapy that is easy to use and designed for operators or users who are not highly skilled or in a busy and overwhelming dialysis room.

Problems solved by technology

From literature search and according to the main opinion leaders in the dialysis field, the determination of dialysis fluid sodium concentration to be used during the dialysis treatment appears as one of the major challenges of dialysis prescription.
Therefore, the method described in U.S. Pat. No. 4,508,622 in not properly an ‘isoconductive’ dialysis treatment.
In any case, ‘isoconductive’ dialysis has been shown to lead to undesired sodium loading in the patient.
As previously mentioned, one of the problems of the dialysis apparatus of the discussed prior art is presently the choice of the appropriate post-dialysis plasmatic conductivity target.
According to this patent, any subject, including hemodialysis patients, has a set level of sodium in his body, referred to as the “set point.” The set point of a subject tends to remain relatively constant, and sodium levels deviating too far from the set point may cause discomfort to the subject.

Method used

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Examples

Experimental program
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first embodiment

[0308] the control unit 12 is programmed to calculate the initial plasma conductivity based on the sum of at least the initial conductivity of the dialysate plus a difference between inlet and outlet conductivity at the filtration unit, or dialyzer, weighted by a factor of the dialysate flow rate. In more detail the difference between inlet and outlet conductivity at the dialyzer is weighted by a factor of the blood flow rate in the blood lines too.

[0309]Specifically, according to the first embodiment, the control unit 12 is configured to calculate the plasma conductivity using the following formula:

κp,1′=κ0,do+QdoQBset(κ0,do-κ0,di)(4)

[0310]The significance of the denotations above is given in the Glossary.

[0311]It is worth to underline that during the above described calculation of the initial plasma conductivity (formula (4)), the dialysis fluid circulates through the secondary chamber 4 maintaining the dialysis fluid parameter value substantially constant.

second embodiment

[0312]In the second embodiment, the control unit 12 is programmed to calculate the initial plasma conductivity based on the sum of at least the initial conductivity of the fresh dialysis fluid plus a difference between inlet and outlet conductivity at the dialyzer weighted by a factor of the dialysate flow rate. In more detail the difference between inlet and outlet conductivity at the filtration unit, or dialyzer, is weighted by a factor of the dialyzer clearance too.

[0313]Specifically, according to the second embodiment, the control unit 12 is configured to calculate the plasma conductivity using the following formula:

κp,1″=κ0,di+QdoKu(κ0,do-κ0,di)(5)

[0314]The significance of the denotations and constants above is given in the Glossary.

[0315]It is worth to underline that during the above described calculation of the initial plasma conductivity (formula (5)), the dialysis fluid circulates through the secondary chamber 4 maintaining the dialysis fluid parameter value substantially c...

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Abstract

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32), a preparation device (9) for preparing and regulating the composition of the dialysis fluid; a control unit (12) is configured for setting a sodium concentration value for the dialysis fluid in the dialysis supply line (8) at a set point; the setting of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the blood plasma conductivity and of an adjustment contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate, and phosphate.

Description

TECHNICAL FIELD[0001]The present invention relates to an apparatus for extracorporeal blood treatment and a method for controlling the extracorporeal blood treatment apparatus.[0002]In particular, the invention may be used for regulating the conductivity of a dialysis liquid during a hemodialysis or hemodiafiltration treatment.[0003]In more detail, the apparatus and the method are particularly adapted for properly regulating the concentration of sodium in the dialysis liquid, particularly to run an isotonic or an isonatremic or an isonatrikalemic dialysis treatment.BACKGROUND OF THE INVENTION[0004]The kidneys fulfil many functions, including the removal of water, the excretion of catabolites (or waste from the metabolism, for example urea and creatinine), the regulation of the concentration of the electrolytes in the blood (e.g. sodium, potassium, magnesium, calcium, bicarbonates, phosphates, chlorides) and the regulation of the acid / base equilibrium within the body, which is obtain...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M1/16A61M1/34
CPCA61M1/1605A61M1/1656A61M1/3406A61M2230/20A61M2230/65A61M2205/128A61M1/1607A61M1/1609A61M1/1666A61M1/3609A61M2230/005
Inventor ROVATTI, PAOLOSURACE, ALESSANDROLODI, CARIO ALBERTOWALLENBORG, ANDERSNILSSON, ANDERSSOLEM, KRISTIANSTERNBY, JANHERTZ, THOMAS
Owner GAMBRO LUNDIA AB
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