Customizable instrument

Abstract

Methods and apparatus that mix a plurality of individual capture reagents for the diagnostic assays are described herein. In an embodiment, a system for optically analyzing a patient sample includes an automated immunochemistry analyzer storing a plurality of capture reagents and a plurality of paramagnetic particles, a user interface configured to allow a selection of a combination of two or more of the capture reagents, and a logic implementer configured to cause the automated immunochemistry analyzer to (i) mix together each capture reagent of the combination of two or more of the capture reagents; (ii) bind the mixture of the combination of two or more of the capture reagents to the paramagnetic particles; (iii) bind the patient sample to the bound mixture of the combination of two or more of the capture reagents; and (iv) optically analyze the patient sample.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to U.S. Provisional Application Ser. No. 62 / 214,740, filed Sep. 4, 2015 and U.S. Provisional Application Ser. No. 62 / 192,989, filed Jul. 15, 2015, the entire disclosure each of which is hereby incorporated.FIELD OF THE DISCLOSURE[0002]The present disclosure relates generally to methods and apparatuses for performing diagnostic assays, and more specifically to methods and apparatus that mix a plurality of individual capture reagents for the diagnostic assays.BACKGROUND OF THE DISCLOSURE[0003]Many immunochemistry analysis systems require that analyte molecules in a patient's biological sample (e.g. serum or plasma) attach to paramagnetic particles. To bind analyte molecules of interest to the paramagnetic particles, a capture reagent is first bound to the paramagnetic particles, and then the patient sample is bound to the capture reagent. The analyses performed by such systems, however, are relatively slow a...

AI Technical Summary

Benefits of technology

[0009]In certain embodiments, the method includes narrowing the number of capture reagents that are available for selection. In other embodiments, selecting from the plurality of selectable capture reagents includes selecting from a plurality of preprogrammed combinations of two or more capture reagents. In yet other embodiments, selecting from the plurality of selectable capture reagents includes individually selecting each capture reagent from the plurality of selectable capture reagents. In yet further embodiments, the method includes performing additional optical analysis using at least one of the two or more capture reagents from the combination if a test using the combination of two or more capture reagents returns a positive result.

Problems solved by technology

The analyses performed by such systems, however, are relatively slow and inefficient because the systems do not provide the capability for a user to customize a mixture of multiple capture reagents and therefore optimize the analysis of the patient sample for different types of analyte molecules of interest.

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