Panax pseudo-ginseng non-woven fabrics and method for preparing same

Abstract

The invention discloses panax pseudo-ginseng non-woven fabrics and a method for preparing the same, which belong to the technical field of trauma dressing. The method for preparing the panax pseudo-ginseng non-woven fabrics comprises two steps: step 1, preparing panax pseudo-ginseng / chitosan / polyacrylic acid solution; step 2, carrying out electrostatic spinning on the pseudo-ginseng / chitosan / polyacrylic acid solution. After the method for preparing is adopted, superfine fibers with diameters of 60-500 nanometers can be obtained through electrostatic spinning, the thickness of a film which is formed by the superfine fibers is between 10-50 micron meters, and the non-woven fabrics produced through adopting the superfine fibers contain 5-15wt.% of panax pseudo-ginseng, 8.5-85.5wt.% of chitosan and 8.5-85.5 wt.% of polyacrylic acid and can be used as the trauma material or dressing. The method for preparing is simple, chitosan has good compatibility, and the non-woven fabrics obtained through adopting the technical scheme are used as the trauma material or dressing, have the functions in stopping bleeding, activating blood, dissolving stasis, eliminating swelling, stabilizing pain and the like, have good cell affinity and can promote tissue recovery.

Description

technical field

[0001] The invention relates to a wound dressing, in particular to a non-woven long-acting sustained-release wound dressing containing Panax notoginseng powder and a preparation method thereof. Background technique

[0002] Notoginseng powder is powder made from the main root of Notoginseng, also known as Notoginseng powder, which is not changed by gold. Rich in active ingredients such as notoginseng saponins, notoginseng polysaccharides, notoginseng, and flavonoids, it has the functions of stopping bleeding, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and has a significant curative effect. Chitosan is a deacetylated product of chitin, which has a chemical structure similar to glycosaminoglycan in the extracellular matrix, and can be degraded by lysozyme. It has been used in biomedical products such as artificial skin and surgical sutures. Therefore, wrapping the notoginseng powder in the chitosan fiber membra...

Examples

Embodiment 1

[0019] Take 0.6g of chitosan with a molecular weight of 100,000 and dissolve it in 10g of 80wt.% acetic acid solution at 60°C to obtain a chitosan solution; take 1.0g of polyacrylic acid with a molecular weight of 150,000 and dissolve it in 10g of deionized water to obtain Polyvinyl acid solution; after mixing according to the mass ratio of chitosan solution: polyacrylic acid solution = 1:1, add 0.16 g of Panax notoginseng powder of 1500 mesh (about 170 nm in diameter), and perform ultrasonic mixing for 0.5 h to obtain spinning Silk solution; after injecting the above spinning solution into a syringe (capacity of 20mL) with a flat needle (1.2mm inner diameter), fix the syringe on the micro-injection pump, place a metal receiving screen at a distance of 15cm from the needle, and place the needle and 20 kV high-voltage DC power supply was connected, and the flow rate was set at 1.0 mL / h for electrospinning. After 20 h, the fiber membrane on the receiving screen was collected. The...

Embodiment 2

[0022] Take 0.3g of chitosan with a molecular weight of 200,000 and dissolve it in 10g of 80wt.% acetic acid solution at 60°C, take 0.3g of polyacrylic acid with a molecular weight of 400,000 and dissolve it in 10g of deionized water, and then dissolve it according to the chitosan: polyethylene After mixing at a mass ratio of acid=9:1, add 0.06 g of Panax notoginseng powder of 1500 mesh (about 170 nm in diameter), and perform ultrasonic mixing for 0.5 h to obtain a spinning solution; After injecting the above spinning solution into the mL syringe, fix the syringe on the micro-injection pump, place a metal receiving screen at a distance of 15 cm from the needle, connect the needle to a 20 kV high-voltage DC power supply, and set the flow rate to 1.0 mL / h for electrospinning After 20 h, collect the fibrous membrane on the receiving screen, which is a superfine fiber membrane with a diameter of about 100-300 nm.

[0023] The fibrous membrane can be made into wound materials or dr...

technical field

[0001] The invention relates to a wound dressing, in particular to a non-woven long-acting sustained-release wound dressing containing Panax notoginseng powder and a preparation method thereof. Background technique

[0002] Notoginseng powder is powder made from the main root of Notoginseng, also known as Notoginseng powder, which is not changed by gold. Rich in active ingredients such as notoginseng saponins, notoginseng polysaccharides, notoginseng, and flavonoids, it has the functions of stopping bleeding, promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, and has a significant curative effect. Chitosan is a deacetylated product of chitin, which has a chemical structure similar to glycosaminoglycan in the extracellular matrix, and can be degraded by lysozyme. It has been used in biomedical products such as artificial skin and surgical sutures. Therefore, wrapping the notoginseng powder in the chitosan fiber membra...

Examples

Embodiment 1

[0019] Take 0.6g of chitosan with a molecular weight of 100,000 and dissolve it in 10g of 80wt.% acetic acid solution at 60°C to obtain a chitosan solution; take 1.0g of polyacrylic acid with a molecular weight of 150,000 and dissolve it in 10g of deionized water to obtain Polyvinyl acid solution; after mixing according to the mass ratio of chitosan solution: polyacrylic acid solution = 1:1, add 0.16 g of Panax notoginseng powder of 1500 mesh (about 170 nm in diameter), and perform ultrasonic mixing for 0.5 h to obtain spinning Silk solution; after injecting the above spinning solution into a syringe (capacity of 20mL) with a flat needle (1.2mm inner diameter), fix the syringe on the micro-injection pump, place a metal receiving screen at a distance of 15cm from the needle, and place the needle and 20 kV high-voltage DC power supply was connected, and the flow rate was set at 1.0 mL / h for electrospinning. After 20 h, the fiber membrane on the receiving screen was collected. The...

Embodiment 2

[0022] Take 0.3g of chitosan with a molecular weight of 200,000 and dissolve it in 10g of 80wt.% acetic acid solution at 60°C, take 0.3g of polyacrylic acid with a molecular weight of 400,000 and dissolve it in 10g of deionized water, and then dissolve it according to the chitosan: polyethylene After mixing at a mass ratio of acid=9:1, add 0.06 g of Panax notoginseng powder of 1500 mesh (about 170 nm in diameter), and perform ultrasonic mixing for 0.5 h to obtain a spinning solution; After injecting the above spinning solution into the mL syringe, fix the syringe on the micro-injection pump, place a metal receiving screen at a distance of 15 cm from the needle, connect the needle to a 20 kV high-voltage DC power supply, and set the flow rate to 1.0 mL / h for electrospinning After 20 h, collect the fibrous membrane on the receiving screen, which is a superfine fiber membrane with a diameter of about 100-300 nm.

[0023] The fibrous membrane can be made into wound materials or dr...

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