Function of Dangshen-Huangqi composition in treating the ischemic heart disease
A technology of ischemic heart disease and composition, applied in the application of myocardial infarction, Codonopsis Astragali composition, myocardial hypoxia, the field of treatment of myocardial ischemia, can solve the problem that there is no experimental data on the effect of the drug, and there is no definite proof of the curative effect To achieve the effect of shortening the length of peripheral thrombus, increasing coronary blood flow, and reducing weight
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Publication Date
- 2004-11-17
- Estimated Expiration
- Not applicable · inactive patent
Smart Images
Figure 1
Abstract
Description
technical field
[0001] The invention relates to the application of a Codonopsis Radix and Astragalus composition in ischemic heart disease. Specifically, the present invention relates to the application of Codonopsis Radix Astragali composition in treating myocardial ischemia, myocardial hypoxia and myocardial infarction. The present invention also relates to the use of the Codonopsis Radix Astragali composition in treating diseases caused by platelet aggregation, such as thrombosis and the like. Background technique
[0002] Angina pectoris of coronary heart disease is a clinical syndrome caused by temporary myocardial ischemia and hypoxia, with episodic chest pain or chest discomfort as the main manifestation. Angina pectoris often occurs when labor, emotional agitation or other factors increase myocardial oxygen consumption. The pain can often radiate to the left shoulder, neck pharynx or mandible, and can be relieved within a few minutes by rest or nitroglycerin. In ad...
Examples
Embodiment 1
[0038] Codonopsis pilosula and Astragalus membranaceus are removed from impurities and processed into decoction pieces. Accurately weigh 400 grams each of Dangshen Radix Astragali, rinse with deionized water, add 3200ml of deionized water, heat and extract for 1 hour, and release the extract; then add 2400ml of deionized water, heat and extract for 1 hour, and then release the extract; Add 2400ml of deionized water, heat and extract for 0.5 hours, and release the extract. Merge after three extracts are filtered, concentrate to 600ml, then add the ethanol that concentration is 95% to make alcohol content be 60%, precipitate for 24 hours, filter; 80%, precipitated, filtered, recovered ethanol and concentrated to 400g to obtain the Codonopsis and Radix Astragali extract composition.
[0039] The medicine of the present invention can be stored in cold storage with an appropriate amount of ethanol, or stored at room temperature after being dried. In the medicine of the present in...
Embodiment 2
[0041] Effects of Dangshen and Huangqi composition on myocardial ischemia, myocardial infarction and related coronary blood flow, myocardial oxygen consumption and blood biochemical indicators in anesthetized dogs
[0042] Thirty healthy adult dogs, both male and female, weighing 14.02±1.90kg, were provided by Beijing Tongli Experimental Animal Breeding Factory [Jing Dong Xu Zi (2000) No. 010].
[0043] experimental drug : Codonopsis Radix Astragalus composition concentrate: 5ml / branch, 2g crude drug / ml; Hebeishuang injection (diltiazem hydrochloride injection): 10mg / branch, produced by Tianjin Tanabe Pharmaceutical Co., Ltd. (batch number: 0003003); 0.9% chlorination Sodium injection: produced by Beijing Shuanghe Pharmaceutical Co., Ltd. (batch number: 000320332); Danshen injection: 10ml / bottle, 1.5g / ml, produced by Hangzhou Zhengda Qingchunbao Pharmaceutical Co., Ltd. (batch number: 0003132); Nitro blue tetrazolium (N-BT): Drug Supply Station of PLA Academy of Military Medica...
Embodiment 3
[0086] Effect of Dangshen and Astragalus Composition on Myocardial Infarction Caused by Ischemia-Reperfusion
[0087] Fifty-six Wistar rats, male, weighing 260-280 g, were provided by the Department of Animals, Beijing Medical University, certificate number: Yidongzi No. 01-3056.
[0088] Drugs: Dangshen and Huangqi composition: 5ml / branch, 2g crude drug / ml; Hebeishuang injection (diltiazem hydrochloride injection): 10mg / branch, produced by Tianjin Tanabe Pharmaceutical Co., Ltd. (batch number: 0003003); Salvia miltiorrhiza injection: 10ml / stick, 1.5g / ml, produced by Zhengda Qingchunbao Pharmaceutical Co., Ltd., Hangzhou, Zhejiang (batch number: 0003132); nitro blue tetrazolium (N-BT): medicinal material supply station of PLA Academy of Military Medical Sciences (batch number: 971120).
[0089] experimental method: Animals were randomly divided into 6 groups: sham operation group (serum was taken as normal control), model group, Hebeishuang 1.0mg / kg group, Danshen injectio...