The invention provides an integrated
system and method for fabricating, regenerating, and maintaining synthetic living
wood tissue constructs. The platform utilizes a formulation subsystem that prepares
plant-derived precursor cells, lineage-directing Exomix signaling vesicles, and a supportive
cellulose-based hydrogel into a printable bio-ink. An additive biofabrication subsystem generates structured constructs containing organized cambial,
xylem, and
phloem domains, microfluidic vascular channels, and embedded niche reservoirs. A maintenance and repair subsystem preserves
tissue viability, delivers targeted regeneration cues, and supports long-term integration with damaged or aging wood substrates. Environmental control modules regulate electrical, mechanical, thermal, and biochemical parameters to guide differentiation and maturation. The invention enables
sustainable production of regenerative wood materials with enhanced strength, decay resistance, and customizable properties, addressing limitations of natural wood through controlled
biomanufacturing and restoration workflows.