The invention discloses anti-bacterial and mildewproof PVC granules for a refrigerator door seal. The PVC granules are characterized by comprising the following raw materials in parts by weight: 10-20 parts of PVCSG-5, 20-30 parts of PVCSG-3, 1-2 parts of cellulose acetate butyrate, 0.2-0.4 part of polydimethylsiloxane, 0.2-0.4 part of petroleum sodium sulfonate, 0.2-0.4 part of sodium stearate, 10-20 parts of epoxidized soybean oil, 1-2 parts of palm oil, 1-2 parts of ricinus oil, 0.1-0.2 part of alginic acid propylene glycol ester, 0.1-0.2 part of pentaerythritol stearate, 0.1-0.2 part of sorbitol anhydride monooleate, 30-40 parts of acetyl tributyl citrate and 2-4 parts of performance additive. The PVC granules comprise natural extractives of tea polyphenol, rosmarinic acid, and the like, has anti-bacterial and mildewproof efficacy, is safe and environment-friendly, has favorable light fastness, low temperature resistance, age resistance, fire and flame retardancy and mechanical property, and is high in practicability.