2results about How to "Good potential" patented technology

The application discloses a 3-hydroxypyrrolidine derivative and a preparation method and application thereof. The structural formula of the 3-hydroxypyrrolidine derivative is shown in formula (I) or formula (II). The 3-hydroxypyrrolidine derivatives shown in formula (I) and formula (II) are non-diastereoisomers. The 3-hydroxypyrrolidine derivative provided by the application can inhibit the proliferation of RAW264.7 cells, and further inhibit the excessive proliferation of macrophages in immune cells to a certain extent. The 3-hydroxypyrrolidine diastereoisomers are obtained through one-pot reaction of a suitable reaction substrate under the action of a copper catalyst, the reaction condition is simple, and a good yield is obtained, so that the problems of needing to pass through multiple synthesis steps, high reaction risk, low reaction efficiency and low yield in the prior art are solved, and a new green synthesis route for the preparation of the 3-hydroxypyrrolidine derivative is provided.

The application belongs to the technical field of organic synthesis, and particularly relates to a preparation method of a chiral dihydroquinolone compound. The application utilizes N-heterocyclic carbene (NHC) as a catalyst, and generates the chiral dihydroquinolone through a nitrogen hetero-diene Diels-Alder reaction of a chloroaldehyde and an azo-ortho-benzoquinone precursor under the action of NHC and an alkaline reagent. The preparation method of the application does not need to use a transition metal as a catalyst, can perform a reaction under relatively mild conditions, and has the advantages of green environmental protection, low cost, wide substrate selectivity, mild reaction conditions and the like. In addition, by optimizing the reaction conditions of the preparation method, the product has high yield, high purity, unique cis selectivity and excellent enantioselectivity. The application provides a new route and new idea for the chiral dihydroquinolone compound, can play an important role in the fields of drug intermediates and the like, and has good application value and potential.