The invention discloses a manufacturing method of a simulation fracture for a fractured rock mass seepage test. The manufacturing method comprises the steps of drawing a fracture digitized profile curve, constructing a fracture three-dimensional model, making a fracture plate through 3D (three-dimensional) printing, making a fracture test piece casting model and performing casting and maintenance of a fracture test piece, specifically, through digitizing a rock structural surface joint roughness profile curve, drawing the fracture three-dimensional model on the basis of CAD (Computer Aided Design) software, making the fracture plate satisfying JRC value fluctuation by adopting a 3D printing technology, making the fracture test piece casting model by combining the fracture test piece, forming by using cement mortar to cast, and making the fracture test piece by performing maintenance in a cement test piece maintenance box for 28 days. The manufacturing method has the beneficial effects: the manufacturing method of rock rough fracture analogue simulation which is easy in observing, simple in manufacturing, convenient in testing, convenient for adjusting fracture opening, and capable of truly and accurately reflect rock mass fracture structural surface roughness is provided, the working procedures are simple and clear, the manufacturing duration is short, economy and efficiency are realized, the accuracy is high, and the adaptability is good.