The invention discloses a cold chain box for transporting shrimp and rice symbiotic food materials. The cold chain box comprises a box body, the box body is hinged to a box cover through a hinge mechanism, moving wheels are hinged to one side of the bottom end of the box body, a handle is hinged to the top end of the inner side of a groove, a protruding frame is integrally formed and connected to the edge of the upper surface of the box body, a clamping groove matched with the protruding frame is formed in the edge of the inner surface of the box cover, a side supporting rod is hinged to the end, away from the box body, of the inner side of a first containing groove, a baffle mechanism is inserted into the inner side of an inserting groove, lock catches are hinged to the two sides, away from the box body, of the box cover, a rotary buckle mechanism is arranged on the upper portion of the inner side of a third containing groove, a clamping strip is integrally formed and connected to the lower portion of the inner side of the third containing groove, and the other ends of the lock catches are integrally formed and connected with a fourth containing groove clamped with the clamping strip. The structure is compact, the box body and the box cover are tightly combined, the sealing effect is good, the quality of transported shrimp and rice symbiotic food materials is guaranteed, a buffering structure is arranged, collision is prevented, and it is guaranteed that the food materials and the box body are intact.