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Sustained release composition for oral administration of drugs

A slow-release composition, the technology of the composition, which is applied in the directions of drug combination, drug delivery, antipyretic drug, etc., can solve problems such as easy degradation

Inactive Publication Date: 2007-10-17
HANMI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this preparation is erodible, and there is a problem that it is easily degraded under the contraction movement of the stomach

Method used

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  • Sustained release composition for oral administration of drugs
  • Sustained release composition for oral administration of drugs
  • Sustained release composition for oral administration of drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-21

[0035] Examples 1-21: Preparation of Tablets

[0036] Nifedipine (Unique Chemicals, India), Isradipine (Sun Pharm.India), Lovastatin (CKD Pharm.KOREA), Glipizide (Sun Pharm.India), Sodium Alginate (Keltone  HVCR, Keltoen  LVF, Kelcosol  , Kelset  , ISP USA), xanthan gum (Keltrol  F, Kelco, USA), locust bean gum (Cesagum  LN1, LR200, Cesalpinia, Italy), propylene glycol alginate (Kelcoloid HVF, LVF, ISP, USA), hydroxypropyl methylcellulose (Meltose 90SH, 4,000SR, 100,000SR, Shin-Etsu, Japan) and kofovidone ( Kollidon VA65, BASF, Germany) was mixed for 30 minutes as described in Table 1, magnesium stearate and light anhydrous silicic acid (below 30 mesh) were added thereto and mixed for 5 minutes. Then, the resulting mixture is tableted by a pressure commonly used in tablet preparation, thereby obtaining tablets.

[0037] drug

[0038] drug

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Abstract

A sustained-release composition for oral administration of a drug, comprising the drug, a mixture of sodium alginate and xanthan gum as a carrier for sustained release and a mixture of hydroxypropyl methylcellulose and propylene glycol alginate as a gel hydration accelerator, which is capable of maintaining a constant drug level in blood for 24 hours or more owing to the fact that the drug release rate follows zero order kinetics and does not significantly vary with the degree of gastrointestinal motility due to rapid gel hydration without forming a non-gelated core.

Description

technical field [0001] The present invention relates to a sustained-release composition for oral administration of a drug capable of maintaining a constant blood drug concentration for 24 hours or longer, comprising the drug, a sustained-release carrier for the drug, and a gel hydration accelerator . Background technique [0002] Once injected, the drug remains active in the body only for a short time, so long-term treatment requires repeated administration of the drug. For example, to treat high blood pressure, a drug such as nifedipine should be administered more than 3 times a day. [0003] Therefore, many efforts have been made to develop a sustained release formulation capable of maintaining an effective in vivo drug concentration for more than 24 hours. For example, Japanese Patent Publication No. 6001716A (1994.1.11) discloses a solid dispersion preparation based on hydroxypropyl methylcellulose matrix, while European Patent Publication No. 521310A (1993.1.7) disclo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/00A61K47/36A61P11/00A61P21/00A61P25/00A61P29/00A61P3/00A61P31/00A61P5/00A61P9/00A61K9/20A61K9/22A61K31/366A61K31/4422A61K31/4439A61K31/64A61K45/00A61K47/38A61P3/06A61P3/10A61P5/38A61P9/04A61P9/12A61P11/06A61P11/10A61P21/02A61P25/20A61P31/04
CPCA61K9/2054A61K9/205A61P11/00A61P11/06A61P11/10A61P21/00A61P21/02A61P25/00A61P25/20A61P29/00A61P3/00A61P3/10A61P31/00A61P31/04A61P3/06A61P5/00A61P5/38A61P9/00A61P9/04A61P9/12A61K47/00
Inventor 禹钟守池文赫
Owner HANMI PHARMA