Unlock instant, AI-driven research and patent intelligence for your innovation.

Genes whose expression is increased in response to stimulation by corticotropin-releasing hormone

An adrenal cortex, hormone-releasing technology, applied in the determination/inspection of microorganisms, peptide sources, drug combinations, etc., can solve problems such as unexplored main fields

Inactive Publication Date: 2007-12-05
JANSSEN PHARMA NV
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the downstream pathways of CRH-activated receptors have been extensively studied in AtT20-cells, a cell model of corticotropic cells, and led to the identification of many genes involved in the signaling cascade, one major area has not been explored

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Genes whose expression is increased in response to stimulation by corticotropin-releasing hormone
  • Genes whose expression is increased in response to stimulation by corticotropin-releasing hormone
  • Genes whose expression is increased in response to stimulation by corticotropin-releasing hormone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] As used herein, the term "compound" or "agent" refers to a biological or chemical compound such as a simple or complex organic molecule, peptide, protein or oligonucleotide. A "test compound" as used herein refers to a "compound" or "agent" used in a method according to the invention to assess whether said compound modulates CRH signaling activity.

[0016] As used herein, "CRH signaling" refers to changes in the transcription of genes in a cell after CRH activates the corticotropin releasing hormone receptor in said cell. It thereby induces a CRH-specific gene expression profile. Changes in transcript levels can be assessed at the protein or gene-RNA level.

[0017] "CRH responsive activity" as used herein generally refers to changes in detectable cellular parameters resulting from exposure of cells to CRH. Detectable cellular parameters include changes in membrane potential, changes in the enzymatic activity of enzymes that regulate CRH signaling in said cell, chang...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates generally to therapy and diagnosis of depression. In particular this invention relates to the polypeptides as well as to the polynucleotides encoding these polypeptides, wherein said polypeptides are shown to play a central role in mediating the endocrine response to corticotropin releasing hormone. These polypeptides and polynucleotides are useful in the diagnosis, treatment and / or prevention of depression.

Description

[0001] The present invention relates generally to the treatment and diagnosis of depression. In particular, the present invention relates to polypeptides, and polynucleotides encoding these polypeptides, which have been shown to play a major role in mediating cellular responses to corticotropin releasing hormone. These polypeptides and polynucleotides can be used in the diagnosis, treatment and / or prevention of depression. Background of the invention [0002] Recent socioeconomic analyzes have found depression to be the leading cause of incapacity and a major risk factor for the development of other disorders. Furthermore, depression is underdiagnosed and undertreated on a worldwide scale. Recent antidepressants have proven effective, but suffer from slow onset of action and side effects. In this regard, it remains unclear by which pharmacological mode of action they exert their clinical effects. Hypothesis-driven research based on the corticosteroid receptor hypothesis for...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/47C12N15/10G01N33/53C12Q1/68A61P25/24
CPCC07K14/47A61P25/24
Inventor P·J·彼得斯H·W·H·格尔曼S·M·A·斯瓦格马克斯F·L·P·费伦斯
Owner JANSSEN PHARMA NV