Peony astragalus polyglucoside composition for treating liver disease and its preparation method
A composition and technology of peony root are applied in the field of pharmaceutical compositions and their preparation, which can solve the problems of lack and the like, and achieve the effects of easy quality control, good therapeutic efficacy and small effective dose.
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[0024] One of the preparation methods of preparation medicine:
[0025] 1. Preparation of total glucosides of paeony:
[0026] Take Radix Paeoniae Alba in proportion, and process it into common Chinese medicine decoction pieces according to Chinese Pharmacopoeia 2000 edition one: put the Radix Paeoniae Alba into alcohol-water system, the concentration of ethanol is 0-95%, and the weight ratio is Radix Paeoniae Alba: Alcohol=1:2-15, extract 2-4 times, each extraction time is 0.5-5 hours, to obtain ethanol extract; concentrate the ethanol extract under reduced pressure until there is no ethanol smell, filter, and use D101, D-3520 . solution, concentrated under reduced pressure, and dried under reduced pressure to obtain total glucosides of paeony powder.
[0027] 2. Preparation of total astragalus saponins:
[0028] Get Radix Astragali medicinal material in proportion, process it into common Chinese herbal decoction pieces according to Chinese Pharmacopoeia 2000 edition one; ...
Embodiment 1
[0068] Take 80kg of Radix Paeoniae Alba and 20kg of Radix Astragali, crush them into coarse powder, put them into an extraction tank, add 800L of water to boil for 3 times, each time for 1 hour, filter the extract while it is hot, let it cool, and put it on D101 macroporous adsorption resin Column, fully eluted with water until the effluent is clear and has no reducing sugar reaction, then eluted with 70% ethanol, collected the 70% ethanol eluate, recovered to near dryness under reduced pressure, and dried under reduced pressure to obtain paeoniflorin Composition 1.9 kg.
[0069] It was determined that the total glycosides content in the paeoniflorin polyglycoside composition obtained in the above experiment was 63%, of which total glucosides of paeony accounted for 86%, and total saponins of Astragalus accounted for 14%.
Embodiment 2
[0071] Take 80kg of Radix Paeoniae Alba and 20kg of Radix Astragali, cut into decoction pieces, put them in an extraction tank, add 1000L of 70% ethanol to extract 3 times, each time for 1.5h, filter the extract while it is hot, let it cool, and absorb it on NKA macropores Resin column, fully eluted with water until the effluent is clear and has no reducing sugar reaction, then eluted with 70% ethanol, collected 70% ethanol eluate, recovered to near dryness under reduced pressure, and dried under reduced pressure to obtain Paeoniae alba Glycoside composition 1.6kg.
[0072] It was determined that the content of total glycosides in the paeoniflorin polyglycoside composition obtained in the above experiment was 76%, of which total glucosides of paeony accounted for 87%, and total saponins of Astragalus accounted for 13%.
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