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Radix bupleuri dripping pill and its preparing method

A technology of Bupleurum and dripping pills, applied in the field of Bupleurum dripping pills, can solve the problems of Bupleurum injection and Bupleurum oral liquid, such as inconvenient use and carrying, discarding, and clinical application restrictions, and achieves convenient swallowing and rapid release Fast, convenient storage and transportation

Active Publication Date: 2008-11-05
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the active ingredient of Bupleurum injection is only volatile oil, and other active ingredients such as saikosaponin are all discarded
In addition, Bupleurum Injection and Bupleurum Oral Liquid are inconvenient to use and carry, which greatly limits their clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] a. Take 1.25 kg of Bupleurum bupleuri, add water and reflux twice, add 5 times the amount of water for the first time, heat and reflux for 2 hours; add 2.5 times the amount of water for the second time, heat and reflux for 1 hour, combine the extracts, and concentrate to The volume ratio of the crude drug to the extract is 1:0.8, add 95% ethanol for precipitation to bring the alcohol content to 70%, let it stand, filter, concentrate and recover the ethanol to a relative density of 1.35, and obtain Bupleurum extractum;

[0053] b. Take the above Bupleurum extract and mix it with polyethylene glycol 6000 in a ratio of 1:3;

[0054] c. Preparation of the product: Take the above Bupleurum extract and polyethylene glycol 6000 and heat it to 90°C, move it into the drip irrigation of the dropping pill machine and keep it at 70°C, drop it into the liquid paraffin at 8°C, take out the dripping pill, and remove the liquid paraffin , choose pills, and make 1000 dropping pills.

Embodiment 2

[0056] a. Take 1.25 kg of Bupleurum bupleuri, add water and reflux twice, add 4 times the amount of water for the first time, heat and reflux for 1 hour; add 2 times the amount of water for the second time, heat and reflux for 1 hour, combine the extracts, and concentrate to The volume ratio of the crude drug to the extract is 1:0.6, add 95% ethanol for precipitation to make the alcohol content reach 50%, let it stand, filter, concentrate and recover the ethanol to a relative density of 1.35, and obtain the Bupleurum extract;

[0057] b. Take the above Bupleurum extract and mix it with polyethylene glycol 6000 in a ratio of 1:3;

[0058] c. Preparation of the product: Take the above-mentioned Bupleurum extract and polyethylene glycol 6000 and heat it to 85°C, move it into the drip irrigation of the dropping pill machine and keep it at 70°C, drop it into the liquid paraffin at 8°C, take out the dripping pill, and remove the liquid paraffin , choose pills, and make 1000 dropping...

Embodiment 3

[0060] a. Take 1.25 kg of Bupleurum bupleuri, add water and reflux twice, add 6 times the amount of water for the first time, heat and reflux for 1 hour; add 2 times the amount of water for the second time, heat and reflux for 1 hour, combine the extracts, and concentrate to The volume ratio of the crude drug to the extract is 1:0.7, add 95% ethanol for precipitation to bring the alcohol content to 60%, let it stand, filter, concentrate and recover the ethanol to a relative density of 1.35, and obtain the Bupleurum extract;

[0061] b. Take the above Bupleurum extract and mix it with polyethylene glycol 6000 in a ratio of 1:3;

[0062] c. Preparation of the product: Take the above Bupleurum extract and polyethylene glycol 6000 and heat it to 95°C, move it into the drip irrigation of the dripping machine and keep it at 65°C, drop it into the liquid paraffin at 8°C, take out the dripping pills, and remove the liquid paraffin , choose pills, and make 1000 dropping pills.

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Abstract

The present invention discloses a kind of Radix bupleuri dripping pill and its preparation process. Radix bupleuri is twice refluxed in water, the extracted liquid is merged, concentrated, alcohol deposited and filtered to recover alcohol and obtain Radix bupleuri extractum, and the Radix bupleuri extractum is mixed with supplementary material and prepared into the dripping pill. The present invention also discloses the pharmacological effect of the Chinese medicine.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof. Specifically, the invention relates to a Bupleurum bupleurum drop pill preparation. The invention also discloses its pharmacological action and a preparation method thereof. Background technique [0002] Bupleurum is the dried root of Bupleurum chinense DC. or B. scorzonerifolium Willd. of the Umbelliferae plant. They are commonly called "Northern Bupleurum" and "Southern Bupleurum" according to their different characters. Bupleurum is bitter and cool in nature and enters the liver and gallbladder meridian. Traditional Chinese medicine is used for the treatment of cold and heat, chest fullness and rib pain, bitter mouth and deafness, headache and dizziness, malaria prolapse, irregular menstruation, and uterine prolapse. [0003] Bupleurum has been used as a medicinal material in my country for nearly a thousand years. In recent years, with the develop...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/233A61P1/18A61P1/16A61P37/02A61P13/12A61P25/20A61P11/00A61P25/32
Inventor 吴廼峰闫希军郭治昕杨悦武
Owner TIANJIN TASLY PHARMA CO LTD
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