Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A composition (RCUD) for protecting and/or repairing DNA from oxidative damages and a method thereof

A technology of oxidative damage and composition, applied in the direction of active ingredients of anhydride/acid/halide, drug combination, pharmaceutical formulation, etc., can solve the problems not mentioned

Inactive Publication Date: 2009-04-08
印度科学工业研究所
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of urine or its distillates as a protector of cells from DNA damage and chromosomal variations is not mentioned in the literature and scriptures

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A composition (RCUD) for protecting and/or repairing DNA from oxidative damages and a method thereof
  • A composition (RCUD) for protecting and/or repairing DNA from oxidative damages and a method thereof
  • A composition (RCUD) for protecting and/or repairing DNA from oxidative damages and a method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0048] In the following steps, Kamdhenu Ark was demonstrated to actinomycin D, H 2 o 2 and MnO 2 Protection against DNA damage caused. In this effort, applicants tested actinomycin D, H 2 o 2 and MnO 2 DNA damage against polymorphonuclear leukocytes and protection by modified Kamdhenu Ark (redistilled cow urine distillate) obtained as described above. These experiments are described in the Examples below.

[0049] Protection against DNA damage was observed whether polymorphonuclear leukocytes were pretreated with redistilled cow urine distillate or polymorphonuclear leukocytes were treated with redistilled cow urine distillate when DNA damaging chemicals were added .

[0050] In fact, redistilled cow urine distillate also had a statistically significant reduction in DNA damage caused by the aforementioned DNA damaging agents.

[0051] The examples provided below are only detailed descriptions of the invention of the present application, and should not be construed as l...

Embodiment -I

[0053] The protective effect of redistilled cow urine distillate on the DNA damage of polymorphonuclear leukocytes induced by the DNA damaging chemical agent actinomycin-D was elaborated (Table-2).

[0054] Table 2: DNA damage induced by actinomycin D and the protective effect of redistilled cow urine distillate (modified K-Ark) Percentage of each group

[0055] Experiment Details

Group I

Group II

Group III

Group IV

Group V

average

SD

P value

control

(0.1%DMSO)

70

75

69

66

69

70

2.92

-

Kamdhenu

Ark (improved)

70

70

68

74

72

71

2.28

NS

Actinomycin D

(positive control)

40

38

44

28

39

38

5.30

...

Embodiment -2

[0061] Elaborate on the effect of double-distilled cow urine distillate on the DNA damage chemical reagent hydrogen peroxide (H 2 o 2 ) Protective effect on DNA damage caused by polymorphonuclear leukocytes (Table-3).

[0062] Table 3: Hydrogen peroxide (H 2 o 2 ) DNA damage and the protective effect of redistilled cow urine distillate are the percentages of each group

[0063]

Experiment Details

Group

I

Group

II

Group

III

Group

IV

Group

V

average

value

SD

P value

control

(0.1%DMSO)

80

71

70

71

87

76

2.92

-

kamdhenu

Ark (unmodified)

70

70

68

74

72

71

2.28

NS

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A composition useful for protecting and / or repairing DNA from oxidative damages said composition comprising redistilled cow's urine distillate (RCUD) having components benzoic acid, and hexanoic acid, with ammonia content of the composition ranging between 5-15mg / L, and optionally along with anti-oxidants; and a method of protecting and / or repairing DNA from oxidative damages using composition of claim 1, said method comprising steps of estimating the amount of folded DNA in a sample, mixing the said composition to the said DNA either before or after the exposure of the DNA to the oxidatively DNA-damaging agent, and determining percentage folded DNA in the mixture showing protection and / or repair of DNA from oxidative damages.

Description

technical field [0001] A composition useful for protecting and / or repairing DNA from oxidative damage, said composition comprising redistilled cow urine distillate (RCUD), wherein RCUD contains benzoic and caproic acid components, the ammonia content of the composition in the range of 5-15 mg / L, and optionally containing antioxidant; and a method of protecting and / or repairing DNA from oxidative damage using the composition of claim 1, said method comprising the steps of: estimating folded DNA in a sample The composition is mixed into the DNA before or after exposure of the DNA to the DNA oxidative damage agent, and the percentage of folded DNA in the mixture is determined, which represents protection against DNA oxidative damage and / or repair. Background technique [0002] In the Vedas, cow products are compared with divine wine (Rig Veda 10.15pp.47). In Ayurveda, cow urine is one of the ingredients of Panchagavya. According to Susrut, cow urine has several medicinal pro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/22A61P39/06A61K31/19A61K31/192A61K33/02A61K45/06
CPCA61K33/02A61K45/06A61K31/19A61K31/192A61K35/22A61P39/06A61K2300/00
Inventor 查卡巴提·他潘萨拉瓦纳·德维·斯万赛克里什那莫提·坎南都塔·迪潘威塔辛·里施·那瑞恩曼辛卡·苏尼尔·巴克里施那道尔·苏伊什·哈里鲍
Owner 印度科学工业研究所
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com