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Ginkgo leaf extract and its preparation

A technology of extract and ginkgolide, applied in the field of preparation of ginkgo biloba extract and its preparation

Inactive Publication Date: 2009-09-02
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been many reports on the research on ginkgolides and their preparations in the prior art, the research on ginkgolides has not stopped, especially for the separation of ginkgolide monomers and research on derivatives thereof. There are literature reports

Method used

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  • Ginkgo leaf extract and its preparation
  • Ginkgo leaf extract and its preparation
  • Ginkgo leaf extract and its preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0259] Take ginkgolide extract and ginkgo flavonoid extract in a ratio of 19:1 and mix them, take 100 g of the above mixture, add 50 g of starch and 50 g of dextrin, mix well, granulate with ethanol, and compress into tablets. Made into tablets.

Embodiment 2

[0261] Take ginkgolide extract and ginkgo flavone extract in a ratio of 8:1, and mix them, take 100g of the above mixture for later use; take PEG 400 Put 276.0g in a suitable container and add PEG 6000 6.0g, heated to PEG in water bath 6000 Dissolve, stir well, add glycerin 18.0g, add above-mentioned mixture 100g, grind into uniform paste with colloid mill, transfer to the storage barrel of soft capsule machine, press into soft capsule with about 0.3ml mold.

Embodiment 3

[0263] Take ginkgolide extract and ginkgo flavonoid extract in a ratio of 8:1, mix them, and take 5.0 g of the above mixture for use; take 5.0 g of meglumine and add 1000 ml of water for injection to dissolve, and autoclave at 121 ° C for 30 min. After taking it out, heat it to 80°C in the 10,000-grade batching room, add 5.0 g of the above-mentioned mixture of the present invention that has been ground and passed through a 80-mesh sieve, heat it to dissolve, and adjust the pH to 8.0 with 10% citric acid aqueous solution after cooling to room temperature, and add it for injection NaCl 8.0g, add water for injection to adjust to a total of 1000ml, filter in a 100-level sterile workshop with a sterile filter plate lined with a 0.22m microporous membrane, pack in 10ml ampoules, melt seal, quality inspection, printing, and packaging.

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Abstract

The invention discloses a pharmaceutical composition, which is composed of ginkgo flavonoids and ginkgolide according to a certain ratio, and also discloses a preparation prepared from the composition, a preparation method, an identification method and an effective ingredient content determination method. The composition and its preparation can be used for the treatment of ischemic stroke and cerebral infarction, and have the effects of increasing heart rate, increasing coronary artery flow, improving microcirculation and increasing local blood flow.

Description

technical field [0001] The present invention relates to the extract of ginkgo biloba and its preparation. Specifically, it is a combination of ginkgolide extract and ginkgo flavone extract and its pharmaceutical preparation. The invention also relates to the preparation method of the ginkgo leaf extract and its preparation. Background technique [0002] Ginkgo has been used as a medicine for more than 600 years. The research on its pharmacology and other applications began in the 1970s and has developed rapidly in the past ten years. At present, the development and utilization of ginkgolides and ginkgo flavonoids extracted from ginkgo leaves are concentrated superior. According to previous reports, ginkgolides and ginkgo flavonoids have good therapeutic effects on the treatment of cardiovascular and cerebrovascular diseases. There have been many reports on the extraction methods of ginkgolides and ginkgo flavonoids, for example, CN1281856A discloses a method for extractin...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61K31/352A61K9/08A61K36/16G01N30/22G01N30/94A61P9/10
Inventor 肖伟戴翔翎凌娅李明慧曹淑波廖正根
Owner JIANGSU KANION PHARMA CO LTD
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